2.7.1.74: deoxycytidine kinase

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For detailed information about deoxycytidine kinase, go to the full flat file.

Word Map on EC 2.7.1.74

2.7.1.74

leukemia

gemcitabine

thymidine

triphosphate

deaminase

purine

ribonucleotide

deoxynucleoside

pyrimidine

deoxyguanosine

salvage

myeloid

arabinoside

cytarabine

prodrugs

deoxyadenosine

1-beta-d-arabinofuranosylcytosine

deoxyribonucleoside

5'-nucleotidase

cladribine

cross-resistance

ara-ctp

2-chlorodeoxyadenosine

2',2'-difluorodeoxycytidine

fludarabine

dttp

antileukemic

ccrf-cem

dfdctp

2-chloro-2'-deoxyadenosine

gemcitabine-resistant

dado

deoxycytidylate

kinase-deficient

clofarabine

2',3'-dideoxycytidine

5'-phosphorylation

arabinosyl

deoxypyrimidine

t-lymphoblastoid

deoxycoformycin

medicine

2'-deoxyadenosine

deoxythymidine

l-nucleoside

dideoxycytidine

t-lymphoblasts

2',3'-dideoxyinosine

tetrahydrouridine

arabinosylcytosine

anabolites

pharmacology

analysis

Reaction

Synonyms

2'-deoxycytidine kinase, ara-C kinase, arabinofuranosylcytosine kinase, dC kinase, dCK, deoxycytidine kinase, deoxycytidine-cytidine kinase, dNTP:deoxycytidine 5'-phosphotransferase, kinase, deoxycytidine (phosphorylating), NTP:deoxycytidine 5'-phosphotransferase

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.1 Phosphotransferases with an alcohol group as acceptor

2.7.1.74 deoxycytidine kinase

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Results	in table
61	Activating Compound
307	AA Sequence
14	Application
1	CAS Registry Number
31	Cloned(Commentary)
47	Cofactor
15	Crystallization (Commentary)
739	Disease/ Diagnostics
8	Expression
30	General Information
11	General Stability
75	IC50 Value
286	Inhibitors
48	kcat/KM [mM/s]
21	Ki Value [mM]
259	KM Value [mM]
48	Localization
97	Metals/Ions
25	Molecular Weight [Da]
145	Natural Substrates/ Products (Substrates)
203	Organism
7	Pathway
107	PDB ID
18	pH Optimum
3	pH Range
3	pH Stability
17	Posttranslational Modification
92	Protein Variants
35	Purification (Commentary)
9	Reaction
1	Reaction Type
133	Reference
1	Renatured (Commentary)
242	Source Tissue
51	Specific Activity [micromol/min/mg]
11	Storage Stability
544	Substrates and Products (Substrate)
20	Subunits
83	Synonyms
1	Systematic Name
29	Temperature Optimum [°C]
2	Temperature Range [°C]
10	Temperature Stability [°C]
179	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 2.7.1.74 - deoxycytidine kinase

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Bos taurus

at least 24 h, in the presence of dithiothreitol

at least 6 h stable

10 min, 10% loss of activity

inactivation

additional information

Homo sapiens

temperature stability of deoxycytidine kinase activity differs appreciably from deoxyadenosine kinase activity

641937