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2.7.1.76: 2'-deoxyadenosine kinase

This is an abbreviated version!
For detailed information about 2'-deoxyadenosine kinase, go to the full flat file.

Word Map on EC 2.7.1.76

Reaction

ATP
+
2'-deoxyadenosine
=
ADP
 +
dAMP

Synonyms

dAdo/dCyd kinase, dAK, dCK, dCyd kinase/dAdo kinase I, deoxyadenosine kinase, deoxycytidine kinase/deoxyadenosine kinase, dCK/dAK, deoxyguanosine kinase/deoxyadenosine kinase, dGK/dAK, dGuo kinase/dAdo kinase II, kinase, deoxyadenosine (phosphorylating), More, purine-deoxyribonucleoside kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.76 2'-deoxyadenosine kinase

Turnover Number

Turnover Number on EC 2.7.1.76 - 2'-deoxyadenosine kinase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.19
2',2'-difluorodeoxycytidine
pH 8.0
1.82 - 3.7
2'-deoxyadenosine
0.56
2'-deoxycytidine
pH 8.0
3.3
2'-fluoro-arabinosyl adenine
-
0.84
ATP
-
pH 7.6, 37°C, recombinant enzyme
0.62
CTP
-
pH 7.6, 37°C, recombinant enzyme
1.22 - 3.7
deoxyadenosine
0.55 - 1.23
deoxycytidine
0.61
deoxyguanosine
-
pH 7.6, 37°C, recombinant enzyme
0.17
gemcitabine
in 50 mM Tris/HCl, pH 8.0, 10 mM dithiothreitol, 2.5 mM ATP, 2.5 mM MgCl2, 3 mg/ml of bovine serum albumin and 0.5 mM CHAPS
0.0081 - 8.1
thymidine
1.64
TTP
-
pH 7.6, 37°C, recombinant enzyme
0.36
UTP
-
pH 7.6, 37°C, recombinant enzyme