2.7.1.91: sphingosine kinase
This is an abbreviated version!
For detailed information about sphingosine kinase, go to the full flat file.
Word Map on EC 2.7.1.91
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2.7.1.91
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sphingosine-1-phosphate
-
1-phosphate
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sphingolipids
-
ceramide
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endothelial
-
sirnas
-
necrosis
-
agonist
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metastasis
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artery
-
erk
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phospholipase
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fingolimod
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fibrosis
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lymphocyte
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protein-coupled
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sphingomyelinase
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tnf
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pulmonary
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leukemia
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sphingomyelin
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anti-apoptotic
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s1p-induced
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stat3
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pertussis
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mapks
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pro-apoptotic
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mitogen
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sclerosis
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pkc
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rheostat
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signal-regulated
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caspase-3
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pro-survival
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platelet-derived
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lysophospholipids
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cardioprotective
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phytosphingosine
-
drug development
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lymphopenia
-
egress
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glucosylceramide
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medicine
-
fumonisins
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s1p-mediated
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dihydroceramide
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mitogenesis
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pdgf-induced
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ceramide-induced
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lysophosphatidic
-
fcepsilonri
- 2.7.1.91
- sphingosine-1-phosphate
- 1-phosphate
- sphingolipids
- ceramide
- endothelial
- sirnas
- necrosis
- agonist
- metastasis
- artery
- erk
- phospholipase
- fingolimod
- fibrosis
- lymphocyte
-
protein-coupled
- sphingomyelinase
- tnf
- pulmonary
- leukemia
- sphingomyelin
-
anti-apoptotic
-
s1p-induced
- stat3
- pertussis
- mapks
-
pro-apoptotic
-
mitogen
- sclerosis
- pkc
-
rheostat
-
signal-regulated
- caspase-3
-
pro-survival
-
platelet-derived
- lysophospholipids
-
cardioprotective
- phytosphingosine
- drug development
- lymphopenia
-
egress
- glucosylceramide
- medicine
- fumonisins
-
s1p-mediated
- dihydroceramide
-
mitogenesis
-
pdgf-induced
-
ceramide-induced
-
lysophosphatidic
- fcepsilonri
Reaction
Synonyms
dihydrosphingosine kinase, kinase, dihydrosphingosine (phosphorylating), kinase, sphingosine (phosphorylating), More, SGK, SK, SK-1, SK-2, SK1, SK2, sphinganine kinase, sphingoid base kinase, sphingosine kinase, sphingosine kinase 1, sphingosine kinase 2, sphingosine kinase type 1, sphingosine kinase type 2, sphingosine kinase-1, sphingosine kinase-2, SPHK, SPHK-1, SPHK1, SPHK1a, SPHK1b, SPHK2, SPK
ECTree
2.7.1.91 sphingosine kinaseAdvanced search results
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results (IC50 Value
IC50 Value on EC 2.7.1.91 - sphingosine kinase
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IC50 VALUE [mM] 
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.00002
(2R,4S)-2-(hydroxymethyl)-1-[2-[4-([4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]amino)phenyl]ethyl]piperidin-4-ol
Homo sapiens
isoform SphK2, pH and temperature not specified in the publication
-
0.00028
(2S)-2-([3-[4-([4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]amino)phenyl]-1,2,4-oxadiazol-5-yl]methyl)pyrrolidine-1-carboximidamide
Homo sapiens
isoform SphK2, at pH 8.0 and 25°C
-
0.00043
(2S,3S)-3-hydroxy-N-(4-octylbenzyl)pyrrolidine-2-carboxamide
Homo sapiens
-
pH 7.5, 22°C
0.000062
(2S,3S)-3-hydroxy-N-(4-octylphenyl)pyrrolidine-2-carboxamide
Homo sapiens
-
pH 7.5, 22°C
0.0282
(E)-3-(3-(4-((4-(4-chlorophenyl)pyrimidin-2-yl)amino)phenyl)-3-oxoprop-1-en-1-yl)-6-methoxyquinolin-2(1H)-one
Homo sapiens
isoform SphK1, at pH 7.4 and 37°C
-
0.0071 - 0.0141
(E)-6,7-dimethoxy-3-(3-(4-((4-(naphthalen-2-yl)pyrimidin-2-yl)amino)phenyl)-3-oxoprop-1-en-1-yl)quinolin-2(1H)-one
-
0.0031
(E)-6-methoxy-3-(3-(4-((4-(naphthalen-2-yl)pyrimidin-2-yl)amino)phenyl)-3-oxoprop-1-en-1-yl)quinolin-2(1H)-one
Homo sapiens
isoform SphK1, at pH 7.4 and 37°C
-
0.000234
(S)-2-((3-(4-((4-(1-methyl-1H-pyrazol-4-yl)-1H-1,2,3-triazol-1-yl)methyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)pyrrolidine-1-carboximidamide
Homo sapiens
isoform SphK2, at pH 8.0 and 25°C
-
0.000359
(S)-2-((3-(4-((4-(4-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-1-yl)methyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide
Homo sapiens
isoform SphK2, at pH 8.0 and 25°C
-
0.000391
(S)-2-((3-(4-((4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl)methyl)phenyl)-1,2,4-oxadiazol-5-yl)-pyrrolidine-1-carboximidamide
Homo sapiens
isoform SphK2, at pH 8.0 and 25°C
-
0.000266
(S)-2-((3-(4-((4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl)methyl)phenyl)-1,2,4-oxadiazol-5-yl)-pyrrolidine-1-carboximidamide
Homo sapiens
isoform SphK2, at pH 8.0 and 25°C
-
0.00064
(S)-2-((3-(4-((4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl)methyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)pyrrolidine-1-carboximidamide
Homo sapiens
isoform SphK2, at pH 8.0 and 25°C
-
0.000452
(S)-2-((3-(4-((4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl)methyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)pyrrolidine-1-carboximidamide
Homo sapiens
isoform SphK2, at pH 8.0 and 25°C
-
0.000687
(S)-2-((3-(4-((4-(thiophen-2-yl)-1H-1,2,3-triazol-1-yl)methyl)phenyl)-1,2,4-oxadiazol-5-yl)-pyrrolidine-1-carboximidamide
Homo sapiens
isoform SphK2, at pH 8.0 and 25°C
-
0.000254
(S)-2-((3-(4-((4-butyl-1H-1,2,3-triazol-1-yl)methyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide
Homo sapiens
isoform SphK2, at pH 8.0 and 25°C
-
0.000248
(S)-2-((3-(4-((4-cyclopropyl-1H-1,2,3-triazol-1-yl)methyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide
Homo sapiens
isoform SphK2, at pH 8.0 and 25°C
-
0.000396
(S)-2-((3-(4-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)phenyl)-1,2,4-oxadiazol-5yl)methyl)pyrrolidine-1-carboximidamide
Homo sapiens
isoform SphK2, at pH 8.0 and 25°C
-
0.000909
(S)-2-(3-(4-((4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl)methyl)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide
Homo sapiens
isoform SphK2, at pH 8.0 and 25°C
-
0.000269
1-(3-(4-((4-(1-methyl-1H-pyrazol-5-yl)-1H-1,2,3-triazol-1-yl)methyl)phenyl)-1,2,4-oxadiazol-5-yl)cyclopropanecarboximidamide
Homo sapiens
isoform SphK2, at pH 8.0 and 25°C
-
0.000717
1-(3-(4-((4-cyclopropyl-1H-1,2,3-triazol-1-yl)methyl)phenyl)-1,2,4-oxadiazol-5-yl)cyclopropanecarboximidamide
Homo sapiens
isoform SphK2, at pH 8.0 and 25°C
-
0.000261
1-(3-(4-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)phenyl)-1,2,4-oxadiazol-5-yl)cyclopropanecarboximidamide
Homo sapiens
isoform SphK2, at pH 8.0 and 25°C
-
0.0591
3-(((4-((4-(4-chlorophenyl)pyrimidin-2-yl)amino)phenyl)amino)methyl)-6,7-dimethoxyquinolin-2(1H)-one
Homo sapiens
isoform SphK1, at pH 7.4 and 37°C
-
0.0439
4-((4-(4-chlorophenyl)pyrimidin-2-yl)amino)phenol
Homo sapiens
isoform SphK1, at pH 7.4 and 37°C
-
0.0156 - 0.0157
6,7-dihydroxy-3-(((4-((4-(naphthalene-2-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)quinolin-2(1H)-one
-
0.0139 - 0.0187
6,7-dimethoxy-3-(((4-((4-(naphthalen-2-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)quinolin-2(1H)-one
-
0.0079 - 0.0089
6-methoxy-3-(((4-((4-(naphthalen-2-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)quinolin-2(1H)-one
-
0.0024
dimethylsphingosine
Rattus norvegicus
at 37°C, in the presence of 0.25% Triton X-100
0.0024
DL-threo-dihydrosphingosine
Rattus norvegicus
at 37°C, in the presence of 0.25% Triton X-100
0.0000017
[(2R)-1-([4-[(3-cyclohexylphenoxy)methyl]phenyl]methyl)pyrrolidin-2-yl]methanol
-
0.0071
(E)-6,7-dimethoxy-3-(3-(4-((4-(naphthalen-2-yl)pyrimidin-2-yl)amino)phenyl)-3-oxoprop-1-en-1-yl)quinolin-2(1H)-one
Homo sapiens
isoform SphK2, at pH 7.4 and 37°C
-
0.0141
(E)-6,7-dimethoxy-3-(3-(4-((4-(naphthalen-2-yl)pyrimidin-2-yl)amino)phenyl)-3-oxoprop-1-en-1-yl)quinolin-2(1H)-one
Homo sapiens
isoform SphK1, at pH 7.4 and 37°C
-
0.0107
3-((4-(4-chlorophenyl)pyrimidin-2-yl)-1-yl)oxymethyl)quinolin-2(1H)-one
Homo sapiens
isoform SphK1, at pH 7.4 and 37°C
-
0.0182
3-((4-(4-chlorophenyl)pyrimidin-2-yl)-1-yl)oxymethyl)quinolin-2(1H)-one
Homo sapiens
isoform SphK2, at pH 7.4 and 37°C
-
0.0156
6,7-dihydroxy-3-(((4-((4-(naphthalene-2-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)quinolin-2(1H)-one
Homo sapiens
isoform SphK2, at pH 7.4 and 37°C
-
0.0157
6,7-dihydroxy-3-(((4-((4-(naphthalene-2-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)quinolin-2(1H)-one
Homo sapiens
isoform SphK1, at pH 7.4 and 37°C
-
0.0139
6,7-dimethoxy-3-(((4-((4-(naphthalen-2-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)quinolin-2(1H)-one
Homo sapiens
isoform SphK2, at pH 7.4 and 37°C
-
0.0187
6,7-dimethoxy-3-(((4-((4-(naphthalen-2-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)quinolin-2(1H)-one
Homo sapiens
isoform SphK1, at pH 7.4 and 37°C
-
0.0079
6-methoxy-3-(((4-((4-(naphthalen-2-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)quinolin-2(1H)-one
Homo sapiens
isoform SphK1, at pH 7.4 and 37°C
-
0.0089
6-methoxy-3-(((4-((4-(naphthalen-2-yl)pyrimidin-2-yl)amino)phenyl)amino)methyl)quinolin-2(1H)-one
Homo sapiens
isoform SphK2, at pH 7.4 and 37°C
-
0.002
CB5468139
Homo sapiens
IC50 above 0.01 mM, isoform SphK1, at pH 8.0 and 25°C
-
100
CB5468139
Homo sapiens
IC50 above 100 mM, isoform SphK2, at pH 8.0 and 25°C
-
0.01
SLP7111228
Homo sapiens
IC50 above 0.01 mM, isoform SphK2, at pH 8.0 and 25°C
-
0.0000017
[(2R)-1-([4-[(3-cyclohexylphenoxy)methyl]phenyl]methyl)pyrrolidin-2-yl]methanol
Homo sapiens
IC50 below 0.0000017 mM, isoform SphK1, at pH 8.0 and 25°C
-
0.0000017
[(2R)-1-([4-[(3-cyclohexylphenoxy)methyl]phenyl]methyl)pyrrolidin-2-yl]methanol
Homo sapiens
IC50 below 0.0000017 mM, isoform SphK2, at pH 8.0 and 25°C
-
