2.7.1.91: sphingosine kinase
This is an abbreviated version!
For detailed information about sphingosine kinase, go to the full flat file.
Word Map on EC 2.7.1.91
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2.7.1.91
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sphingosine-1-phosphate
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1-phosphate
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sphingolipids
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ceramide
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endothelial
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sirnas
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necrosis
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agonist
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metastasis
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artery
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erk
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phospholipase
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fingolimod
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fibrosis
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lymphocyte
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protein-coupled
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sphingomyelinase
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tnf
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pulmonary
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leukemia
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sphingomyelin
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anti-apoptotic
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s1p-induced
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stat3
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pertussis
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mapks
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pro-apoptotic
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mitogen
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sclerosis
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pkc
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rheostat
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signal-regulated
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caspase-3
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pro-survival
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platelet-derived
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lysophospholipids
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cardioprotective
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phytosphingosine
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drug development
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lymphopenia
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egress
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glucosylceramide
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medicine
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fumonisins
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s1p-mediated
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dihydroceramide
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mitogenesis
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pdgf-induced
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ceramide-induced
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lysophosphatidic
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fcepsilonri
- 2.7.1.91
- sphingosine-1-phosphate
- 1-phosphate
- sphingolipids
- ceramide
- endothelial
- sirnas
- necrosis
- agonist
- metastasis
- artery
- erk
- phospholipase
- fingolimod
- fibrosis
- lymphocyte
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protein-coupled
- sphingomyelinase
- tnf
- pulmonary
- leukemia
- sphingomyelin
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anti-apoptotic
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s1p-induced
- stat3
- pertussis
- mapks
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pro-apoptotic
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mitogen
- sclerosis
- pkc
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rheostat
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signal-regulated
- caspase-3
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pro-survival
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platelet-derived
- lysophospholipids
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cardioprotective
- phytosphingosine
- drug development
- lymphopenia
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egress
- glucosylceramide
- medicine
- fumonisins
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s1p-mediated
- dihydroceramide
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mitogenesis
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pdgf-induced
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ceramide-induced
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lysophosphatidic
- fcepsilonri
Reaction
Synonyms
dihydrosphingosine kinase, kinase, dihydrosphingosine (phosphorylating), kinase, sphingosine (phosphorylating), More, SGK, SK, SK-1, SK-2, SK1, SK2, sphinganine kinase, sphingoid base kinase, sphingosine kinase, sphingosine kinase 1, sphingosine kinase 2, sphingosine kinase type 1, sphingosine kinase type 2, sphingosine kinase-1, sphingosine kinase-2, SPHK, SPHK-1, SPHK1, SPHK1a, SPHK1b, SPHK2, SPK
ECTree
2.7.1.91 sphingosine kinaseAdvanced search results
results (
results (KM Value
KM Value on EC 2.7.1.91 - sphingosine kinase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.02
ATP
recombinant wild-type enzyme, pH and temperature not specified in the publication
0.0255
ATP
recombinant mutant D81N enzyme, pH and temperature not specified in the publication
0.0628
ATP
pH and temperature not specified in the publication, mutant E180Q
0.071
ATP
pH and temperature not specified in the publication, mutant G113A
0.073
ATP
pH and temperature not specified in the publication, mutant K27A
0.0774
ATP
pH and temperature not specified in the publication, mutant D176N
0.078
ATP
pH and temperature not specified in the publication, mutant K29A
0.0884
ATP
pH and temperature not specified in the publication, mutant D178N
0.09
ATP
pH and temperature not specified in the publication, mutant G26A
0.092
ATP
pH and temperature not specified in the publication, mutant K103R
0.0947
ATP
pH and temperature not specified in the publication, mutant E182Q
0.124
ATP
pH and temperature not specified in the publication, mutant S79A
3.8
ATP
pH and temperature not specified in the publication, mutant G82A
0.00247
D-erythro-sphingosine
pH and temperature not specified in the publication, deletion mutant DELTA364-384
0.0102
D-erythro-sphingosine
pH and temperature not specified in the publication, mutant E182Q
0.014
D-erythro-sphingosine
pH and temperature not specified in the publication, mutant K103R
0.018
D-erythro-sphingosine
pH and temperature not specified in the publication, mutant G26A
0.019
D-erythro-sphingosine
pH and temperature not specified in the publication, mutant K29A
0.02
D-erythro-sphingosine
pH and temperature not specified in the publication, mutant G113A
0.02
D-erythro-sphingosine
pH and temperature not specified in the publication, mutant K27A
0.02
D-erythro-sphingosine
pH and temperature not specified in the publication, mutant S79A
0.022
D-erythro-sphingosine
pH and temperature not specified in the publication, mutant G82A
0.0257
D-erythro-sphingosine
pH and temperature not specified in the publication, mutant E180Q
0.0366
D-erythro-sphingosine
pH and temperature not specified in the publication, mutant D176N
0.108
D-erythro-sphingosine
pH and temperature not specified in the publication, mutant D178N
1
nitrobenzoxadiazole-labeled sphingosine
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pH 7.4, 35°C, presence of 10 microM 3-O-sulfogalactosylceramide
1.7
nitrobenzoxadiazole-labeled sphingosine
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pH 7.4, 35°C, presence of 25 microM 3-O-sulfogalactosylceramide
3.6
nitrobenzoxadiazole-labeled sphingosine
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pH 7.4, 35°C, presence of 4 microM 3-O-sulfogalactosylceramide
0.0076
sphingosine
in 50 mM HEPES, pH 7.4, 10 mM KCl, 15 mM MgCl2, 0.1% Triton X-100, 20% glycerol, 2 mM orthovanadate, 2 mM dithiothreitol, 10 mM NaF, and 1 mM deoxypyridoxine
0.01
sphingosine
pH 7.4, 37°C, recombinant wild-type enzyme and mutant E181Q
additional information
additional information
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simple quantitative radio-assay
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additional information
additional information
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assay for measurement of intracellular levels of free sphingoid bases
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additional information
additional information
Michaelis-Menten kinetics
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additional information
additional information
kinetics, isozymes SPHK1 and SPHK2
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additional information
additional information
kinetics, isozymes SPHK1 and SPHK2
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additional information
additional information
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kinetics, isozymes SPHK1 and SPHK2
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additional information
additional information
kinetics, isozymes SPHK1 and SPHK2
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additional information
additional information
kinetics, isozymes SPHK1 and SPHK2
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additional information
additional information
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kinetics, isozymes SPHK1 and SPHK2
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additional information
additional information
kinetics, recombinant wild-type and mutant enzymes
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additional information
additional information
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kinetics, recombinant wild-type and mutant enzymes
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additional information
additional information
substrate kinetic analysis
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additional information
additional information
substrate kinetic analysis
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additional information
additional information
enzyme is an oligomeric protein containing noncooperative catalytic sites, the allosteric site exerts an autoinhibition of the catalytic site
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additional information
additional information
kinetic values of wild-type and mutant enzymes, overview
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additional information
additional information
kinetic values of wild-type and mutant enzymes, overview
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