2.7.1.94: acylglycerol kinase
This is an abbreviated version!
For detailed information about acylglycerol kinase, go to the full flat file.
Word Map on EC 2.7.1.94
-
2.7.1.94
-
translocase
-
intermembrane
-
lysophosphatidic
-
sengers
-
phosphatidic
-
monoacylglycerols
-
preproteins
-
tim10
-
polytopic
-
presequence
-
lpa-induced
-
medicine
-
autotaxin
-
diagnostics
-
drug development
- 2.7.1.94
- translocase
-
intermembrane
-
lysophosphatidic
-
sengers
-
phosphatidic
- monoacylglycerols
- preproteins
- tim10
-
polytopic
- presequence
-
lpa-induced
- medicine
- autotaxin
- diagnostics
- drug development
Reaction
Synonyms
1-MGK, 1-monoacylglycerol kinase, 2-MGK, 2-monoacylglycerol kinase, acylglycerol kinase, AGK, kinase, monoacylglycerol (phosphorylating), MGK, monoacylglycerol kinase, monoglyceride kinase, monoglyceride phosphokinase, More, MULK, multisubstrate lipid kinase, sn-2-monoacylglycerol kinase, TIM22 complex
ECTree
Advanced search results
Application
Application on EC 2.7.1.94 - acylglycerol kinase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
diagnostics
drug development
the enzyme AGK-based mechanism for constitutive activation of JAK2/STAT3 signaling in solid tumors and may represent a therapeutic target
medicine
early-stage cervical squamous cell cancer (CSCC) patients with high AGK expression level had shorter progress-free survival and overall survival time compared with patients with low AGK expression levels, AGK expression level can be an independent prognostic factor for survival of early-stage CSCC patients
diagnostics
overexpression of acylglycerol kinase is associated with poorer prognosis and lymph node metastasis in nasopharyngeal carcinoma and thus the enzyme has potential as a prognostic factor for overall survival in in nasopharyngeal carcinoma, and for lymph node metastasis in nasopharyngeal carcinoma
diagnostics
the enzyme AGK-based mechanism for constitutive activation of JAK2/STAT3 signaling in solid tumors and may represent a prognostic biomarker. AGK overexpression correlates with progression and poor prognosis in human esophageal squamous cell cancer cells
-
homozygous mutation c.3G>A, p.M1I in the gene encoding acylglycerol kinase has been identified in two brothers who presented with vascular strokes, lactic acidosis, cardiomyopathy and cataracts, abnormal muscle cell histopathology and mitochondrial function. One proband had very abnormal mitochondria with citrate synthase crystals visible in electron micrographs, associated with markedly high citrate synthase activity. Homozygous c.979A>T, p.K327* mutation has been identified in a family with four affected members, of which two have been examined. They presented with similar clinical symptoms, but no strokes. Postmortem heart and skeletal muscle tissues showed low complex I, III and IV activities in the heart, but normal in the muscle. Skin fibroblasts showed elevated lactate/pyruvate ratios and low complex I+III activity
medicine
identification of a novel autosomal recessive cataract locus on 7q33-q36.1 in a multiplex consanguineous family with isolated congenital cataractl. Mutation is a splice-site mutation in AGK, encoding acylglycerol kinase, which leads to aberrant splicing and predicted premature truncation
medicine
-
in membranes from patients with proliferative diabetic retinopathy, vascular endothelial cells express autotaxin and acylglycerol kinase in 16 and 19 out of 22 membranes, respectively. Stromal cells express autotaxin and acylglycerol kinase in 19 and 22 out of membranes, respectively. There are significant correlations between number of blood vessels expressing the panendothelial cell marker CD34 and number of blood vessels and stromal cells expressing autotaxin and acylglycerol kinase. In proliferative diabetic retinopathy membranes, spindle-shaped myofibroblasts expressing alpha-smooth muscle actin co-express autotaxin, acylglycerol kinase and LPA1 receptor
medicine
high enzyme expression is significantly associated with the grade of malignancy and poor prognosis in glioma patients. The enzyme is a therapeutic target for treatment of glioma