2.7.1.94: acylglycerol kinase
This is an abbreviated version!
For detailed information about acylglycerol kinase, go to the full flat file.
Word Map on EC 2.7.1.94
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2.7.1.94
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translocase
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intermembrane
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lysophosphatidic
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sengers
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phosphatidic
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monoacylglycerols
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preproteins
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tim10
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polytopic
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presequence
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lpa-induced
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medicine
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autotaxin
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diagnostics
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drug development
- 2.7.1.94
- translocase
-
intermembrane
-
lysophosphatidic
-
sengers
-
phosphatidic
- monoacylglycerols
- preproteins
- tim10
-
polytopic
- presequence
-
lpa-induced
- medicine
- autotaxin
- diagnostics
- drug development
Reaction
Synonyms
1-MGK, 1-monoacylglycerol kinase, 2-MGK, 2-monoacylglycerol kinase, acylglycerol kinase, AGK, kinase, monoacylglycerol (phosphorylating), MGK, monoacylglycerol kinase, monoglyceride kinase, monoglyceride phosphokinase, More, MULK, multisubstrate lipid kinase, sn-2-monoacylglycerol kinase, TIM22 complex
ECTree
2.7.1.94 acylglycerol kinaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.7.1.94 - acylglycerol kinase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 1,2-dioleoyl-sn-glycerol
ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate
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recombinant enzyme
-
-
?
ATP + 1-monoolein
ADP + 1-oleoylglycerol 3-phosphate
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i.e. 1-monooleolylglyerol
-
-
?
ATP + 1-oleoyl-sn-glycerol
ADP + 1-oleoyl-sn-glycerol 3-phosphate
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recombinant enzyme
-
-
?
ATP + 1-palmitoyl-sn-glycerol
ADP + 1-palmitoyl-sn-glycerol 3-phosphate
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recombinant enzyme
-
-
?
ATP + 1-stearoyl-sn-glycerol
ADP + 1-stearoyl-sn-glycerol 3-phosphate
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recombinant enzyme
-
-
?
ATP + 2-arachidonoyl glycerol
ADP + 2-arachidonoylglycerol 3-phosphate
-
-
-
-
?
ATP + 2-monoolein
ADP + 2-oleoyoglycerol 3-phosphate
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i.e. 2-monooleolylglyerol
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-
?
ATP + 1,2-dipalmitoylglycerol
ADP + 1,2-dipalmitoylglycerol 3-phosphate
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-
product identified as alpha-phosphatidic acid
?
ATP + 1,2-dipalmitoylglycerol
ADP + 1,2-dipalmitoylglycerol 3-phosphate
Escherichia coli B / ATCC 11303
-
-
product identified as alpha-phosphatidic acid
?
ATP + 1-palmitoylglycerol
ADP + 1-palmitoylglycerol 3-phosphate
-
-
-
?
ATP + 1-palmitoylglycerol
ADP + 1-palmitoylglycerol 3-phosphate
Escherichia coli B / ATCC 11303
-
-
-
?
ATP + 2-arachidonoyl-glycerol
ADP + 2-arachidonoyl-glycerol 3-phosphate
-
-
-
-
?
ATP + 2-arachidonoyl-glycerol
ADP + 2-arachidonoyl-glycerol 3-phosphate
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recombinant enzyme
-
-
?
ATP + acylglycerol
ADP + acyl-sn-glycerol 3-phosphate
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the enzyme acts on both 1- and 2-acylglycerols, substrate specificity, overview
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-
?
ATP + acylglycerol
ADP + acyl-sn-glycerol 3-phosphate
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the enzyme acts on both 1- and 2-acylglycerols, substrate specificity, overview
-
-
?
ATP + acylglycerol
ADP + acyl-sn-glycerol 3-phosphate
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the enzyme acts on both 1- and 2-acylglycerols, substrate specificity, overview
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-
?
ATP + diacylglycerol
ADP + phosphatidic acid
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-
i.e. diacyl-glycerol 3-phosphate, regulation mechanism, overview
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?
ATP + diacylglycerol
ADP + phosphatidic acid
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i.e. diacyl-glycerol 3-phosphate
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?
ATP + diacylglycerol
ADP + phosphatidic acid
-
-
i.e. diacyl-glycerol 3-phosphate
-
?
ATP + monoacylglycerol
ADP + lysophosphatidic acid
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-
i.e. acyl-sn-glycerol 3-phosphate, regulation mechanism, overview
-
?
ATP + monoacylglycerol
ADP + lysophosphatidic acid
-
-
i.e. acyl-sn-glycerol 3-phosphate
-
?
ATP + monoacylglycerol
ADP + lysophosphatidic acid
-
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i.e. acyl-sn-glycerol 3-phosphate
-
?
additional information
?
-
-
1-monostearin amongst the 1-acylglycerols and 2-monoarachidonin amongst the 2-acylglycerols give the highest activity
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-
?
additional information
?
-
-
preference for substrates with unsaturated fatty acids except for 1- and 2-monostearins
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-
?
additional information
?
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lysophosphatidic acid induces the cytokine interleukin-8 correlated with angiogenesis, tumorigenicity, and cancer cell proliferation, the enzyme modulates cross talk with EGFR in prostate cancer cells, enzyme regulates the synthesis of the bioactive phospholipids lysophosphatidic acid and phosphatidic acid, activation of extracellular signal related kinase 1 and 2, thus being involved in pathenogenesis of cancer via enhanced cell proliferation
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-
?
additional information
?
-
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the enzyme plays a critical role in epidermal growth factor-induced mitogenesis of prostate cancer cells via EGF and IFG-II, and lysophosphatidic acid, the first way can be inhibited by enzyme suppression, the second cannot, enzyme function and regulation in initiation and progression of prostate cancer, lysophosphatidic acid enhances surival and suppresses apoptosis by reducing levels of the apoptosis-promoting protein Bax, and is involved in signal transduction pathways, overview
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-
?
additional information
?
-
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no activity by the recombinant enzyme with C6-ceramide and sphingosine
-
-
?
additional information
?
-
-
in addition to its main activity, phosphorylation of 1,2-diacyl-sn-glycerol to 1,2-diacyl-sn-glycerol 3-phosphate, EC 2.7.1.107, the enzyme also shows acylglycerol kinase activity, EC 2.7.1.94. Both monoacylglycerol kinase activities are low
-
-
?
additional information
?
-
-
in addition to its main activity, phosphorylation of 1,2-diacyl-sn-glycerol to 1,2-diacyl-sn-glycerol 3-phosphate, EC 2.7.1.107, the enzyme also shows acylglycerol kinase activity, EC 2.7.1.94. Both monoacylglycerol kinase activities are very low
-
-
?
additional information
?
-
-
in addition to its main activity, phosphorylation of 1,2-diacyl-sn-glycerol to 1,2-diacyl-sn-glycerol 3-phosphate, EC 2.7.1.107, the enzyme also shows acylglycerol kinase activity, EC 2.7.1.94. The 2-MGK activity is very low
-
-
?
additional information
?
-
-
the enzyme modulates cross talk with EGFR in prostate cancer cells, enzyme regulates the synthesis of the bioactive phospholipids lysophosphatidic acid and phosphatidic acid, activation of extracellular signal related kinase 1 and 2, thus being involved in pathenogenesis of cancer via enhanced cell proliferation
-
-
?
additional information
?
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increasing activity in the order: 1-monoacylglycerol, 2-monoacylglycerol, 1,2-diacylglycerol
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-
?
additional information
?
-
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when saturated fatty acids are present the order of decreasing activity varies directly with increasing chain length for C10 to C20
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-
?
additional information
?
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a single enzyme may function as diacylglycerol and monoacylglycerol kinase
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-
?
additional information
?
-
-
in addition to its main activity, phosphorylation of 1,2-diacyl-sn-glycerol to 1,2-diacyl-sn-glycerol 3-phosphate, EC 2.7.1.107, the enzyme also shows acylglycerol kinase activity, EC 2.7.1.94. The 2-MGK activity is very low
-
-
?
additional information
?
-
-
in addition to its main activity, phosphorylation of 1,2-diacyl-sn-glycerol to 1,2-diacyl-sn-glycerol 3-phosphate, EC 2.7.1.107, the enzyme also shows acylglycerol kinase activity, EC 2.7.1.94. The 2-MGK activity is very low
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-
?
