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2.7.1.95: kanamycin kinase

This is an abbreviated version!
For detailed information about kanamycin kinase, go to the full flat file.

Word Map on EC 2.7.1.95

Reaction

ATP
+
kanamycin
=
ADP
+
kanamycin 3'-phosphate

Synonyms

amino-glycoside-3-phosphotransferase II, aminoglycoside 3'-phosphotransferase, aminoglycoside phosphotransferase, aminoglycoside phosphotransferase 3'-IIIa, i.e. APH3'-IIIa, aminoglycoside phosphotransferase VIII, APH, aph(3'')-IIIa, APH(3')-IIIa, APH(3')II, AphA, kinase, kanamycin (phosphorylating), Neo, neomycin phosphotransferase, neomycin phosphotransferase II, neomycin phosphotransferase-II, neomycin-kanamycin phosphotransferase, NPT, NPT-II, NPTII

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.95 kanamycin kinase

Inhibitors

Inhibitors on EC 2.7.1.95 - kanamycin kinase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Adenylyl imidodiphosphate
-
-
Gentamicin 1a
kanamycin
-
substrate inhibition at 2 mM
tobramycin
ZINC08981682
7% inhibition at 0.5 mM
-
ZINC1143187
12% inhibition at 0.5 mM
ZINC12636347
37% inhibition at 0.5 mM
ZINC13001091
7% inhibition at 0.5 mM
ZINC13236811
43% inhibition at 0.5 mM, 43% inhibition of APH(3')-IIIa, ZINC13236811 acts again as a non-competitive inhibitor towards ATP and kanamycin A
ZINC13572054
37% inhibition at 0.5 mM
ZINC1792615
8% inhibition at 0.5 mM
ZINC22406103
20% inhibition at 0.5 mM
ZINC8790387
79% inhibition at 0.5 mM, competitive inhibitor of APH(3')-IIIa towards ATP, and non-competitive inhibitor towards kanamycin A. The inhibitor may bind to a different location, presumably closer to the nucleotide binding pocket without interfering with the aminoglycoside site
ZINC8981627
3% inhibition at 0.5 mM
additional information
-