2.7.1.95: kanamycin kinase
This is an abbreviated version!
For detailed information about kanamycin kinase, go to the full flat file.
Word Map on EC 2.7.1.95
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2.7.1.95
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agrobacterium
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tumefaciens
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explants
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agrobacterium-mediated
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regenerated
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shoot
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beta-glucuronidase
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retroviral
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calli
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co-cultivation
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kanamycin-resistant
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protoplast
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cauliflower
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tumefaciens-mediated
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embryogenic
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enterococci
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hygromycin
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gentamicin
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bombard
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plantlet
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nopaline
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geneticin
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faecium
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g418-resistant
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disarmed
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acetosyringone
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cotyledonary
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biolistic
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amphotropic
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amikacin
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aminoglycoside-modifying
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co-transformation
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paromomycin
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rhizogenes
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regenerants
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phosphinothricin
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marker-free
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microprojectile
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murashige
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casseliflavus
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hirae
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retroviral-mediated
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medicine
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durans
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self
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thidiazuron
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gentamicin-resistant
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plumbaginifolia
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cry1ac
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aph3\'-iiia
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analysis
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6-benzylaminopurine
- 2.7.1.95
- agrobacterium
- tumefaciens
-
explants
-
agrobacterium-mediated
-
regenerated
- shoot
- beta-glucuronidase
-
retroviral
-
calli
-
co-cultivation
-
kanamycin-resistant
-
protoplast
- cauliflower
-
tumefaciens-mediated
-
embryogenic
-
enterococci
- hygromycin
- gentamicin
-
bombard
-
plantlet
- nopaline
- geneticin
- faecium
-
g418-resistant
-
disarmed
- acetosyringone
- cotyledonary
-
biolistic
-
amphotropic
- amikacin
-
aminoglycoside-modifying
-
co-transformation
- paromomycin
- rhizogenes
-
regenerants
- phosphinothricin
-
marker-free
-
microprojectile
-
murashige
- casseliflavus
- hirae
-
retroviral-mediated
- medicine
- durans
-
self
- thidiazuron
-
gentamicin-resistant
- plumbaginifolia
-
cry1ac
-
aph3\'-iiia
- analysis
- 6-benzylaminopurine
Reaction
Synonyms
amino-glycoside-3-phosphotransferase II, aminoglycoside 3'-phosphotransferase, aminoglycoside phosphotransferase, aminoglycoside phosphotransferase 3'-IIIa, i.e. APH3'-IIIa, aminoglycoside phosphotransferase VIII, APH, aph(3'')-IIIa, APH(3')-IIIa, APH(3')II, AphA, kinase, kanamycin (phosphorylating), Neo, neomycin phosphotransferase, neomycin phosphotransferase II, neomycin phosphotransferase-II, neomycin-kanamycin phosphotransferase, NPT, NPT-II, NPTII
ECTree
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Inhibitors
Inhibitors on EC 2.7.1.95 - kanamycin kinase
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ZINC13236811
43% inhibition at 0.5 mM, 43% inhibition of APH(3')-IIIa, ZINC13236811 acts again as a non-competitive inhibitor towards ATP and kanamycin A
ZINC8790387
79% inhibition at 0.5 mM, competitive inhibitor of APH(3')-IIIa towards ATP, and non-competitive inhibitor towards kanamycin A. The inhibitor may bind to a different location, presumably closer to the nucleotide binding pocket without interfering with the aminoglycoside site
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with neomycin as substrate, no inhibition in E. coli strain JR66/W677 or Pseudomonas aeruginosa strain Ps49
Gentamicin 1a
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with neomycin as substrate, no inhibition in E. coli strain JR66/W677 or Pseudomonas aeruginosa strain Ps49
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not inhibitory: guanylyl imidodiphosphate
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additional information
identification os specific inhibitors of APHs that can restore bacterial susceptibility to aminoglycosides, screening of the Zinc database for search for allosteric inhibitors that bind to small cavities of the protein and block the enzyme function by perturbing its dynamics, docking study usig the crystal structure of the enzyme (PDB ID 1L8T) with removed aminoglycoside substrate, overview. The two interactions with side chain of Arg211 and backbones of Leu209 and Gly210 are shown to play an essential role in the inhibition of APH. No inhibition by ZINC20785546, ZINC20737652, ZINC40455179, ZINC6751595, ZINC14746000, ZINC36589946, and ZINC22357542
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