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2.7.1.95: kanamycin kinase

This is an abbreviated version!
For detailed information about kanamycin kinase, go to the full flat file.

Word Map on EC 2.7.1.95

Reaction

ATP
+
kanamycin
=
ADP
 +
kanamycin 3'-phosphate

Synonyms

amino-glycoside-3-phosphotransferase II, aminoglycoside 3'-phosphotransferase, aminoglycoside phosphotransferase, aminoglycoside phosphotransferase 3'-IIIa, i.e. APH3'-IIIa, aminoglycoside phosphotransferase VIII, APH, aph(3'')-IIIa, APH(3')-IIIa, APH(3')II, AphA, kinase, kanamycin (phosphorylating), Neo, neomycin phosphotransferase, neomycin phosphotransferase II, neomycin phosphotransferase-II, neomycin-kanamycin phosphotransferase, NPT, NPT-II, NPTII

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.1 Phosphotransferases with an alcohol group as acceptor
                2.7.1.95 kanamycin kinase

Reference

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Reference on EC 2.7.1.95 - kanamycin kinase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Doi, O.; Ogura, M.; Tanaka, N.; Umezawa, H.
Inactivation of kanamycin, neomycin, and streptomycin by enzymes obtained in cells of Pseudomonas aeruginoa
Appl. Microbiol.
16
1276-1281
1968
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Doi, O.; Miyamoto, M.; Tanaka, N.; Umezawa, H.
Inactivation and phosphorylation of kanamycin by drug-resistant Staphylococcus aureus
Appl. Microbiol.
16
1282-1284
1968
Staphylococcus aureus
Manually annotated by BRENDA team
Ozanne, B.; Benveniste, R.; Tipper, D.; Davies, J.
Aminoglycoside antibiotics: inactivation by phosphorylation in Escherichia coli carrying R factors
J. Bacteriol.
100
1144-1146
1969
Escherichia coli
Manually annotated by BRENDA team
Reiss, B.; Sprengel, R.; Will, H.; Schaller, H.
A new sensitive method for qualitative and quantitative assay of neomycin phosphotransferase in crude cell extracts
Gene
30
211-218
1984
Escherichia coli, Platyrrhini, Mus musculus
Manually annotated by BRENDA team
Haas, M.J.; Dowding, J.E.
Aminoglycoside-modifying enzymes
Methods Enzymol.
43
611-627
1975
Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Pseudomonas aeruginosa Ps49
Manually annotated by BRENDA team
Nastri, H.G.; Algranati, I.D.
Effect of polyamines on plasmid-mediated kanamycin resistance and kanamycin phosphotransferase gene expression in Escherichia coli
Cell. Mol. Biol.
42
711-717
1996
Escherichia coli
Manually annotated by BRENDA team
McKay, G.A.; Wright, G.D.
Catalytic mechanism of enterococcal kanamycin kinase (APH(3')-IIIa): viscosity, thio, and solvent isotope effects support a Theorell-Chance mechanism
Biochemistry
35
8680-8685
1996
Escherichia coli
Manually annotated by BRENDA team
dos Santos, W.G.; Buck, G.A.
Simultaneous stable expression of neomycin phosphotransferase and green fluorescence protein genes in Trypanosoma cruzi
J. Parasitol.
86
1281-1288
2000
Escherichia coli
Manually annotated by BRENDA team
Rashid, M.B.; Mensa-Wilmot, K.
Novel kanamycin/neomycin phosphotransferase cassette increases transformation efficiency in E. coli
Biotechniques
28
90-94
2000
Escherichia coli
Manually annotated by BRENDA team
Van Houdt, H.; Kovarik, A.; Van Montagu, M.; Depicker, A.
Cross-talk between posttranscriptionally silenced neomycin phosphotransferase II transgenes
FEBS Lett.
467
41-46
2000
Escherichia coli
Manually annotated by BRENDA team
Kromer, W.J.; Bailey, J.E.
Expression of the membrane protein glycophorin A as a fusion with the antibiotic resistance protein neomycin phosphotransferase II
Biotechnol. Bioeng.
57
238-244
1998
Escherichia coli
Manually annotated by BRENDA team
Heng, B.C.; Cao, T.
Immunoliposome-mediated delivery of neomycin phosphotransferase for the lineage-specific selection of differentiated/committed stem cell progenies: potential advantages over transfection with marker genes, fluorescence-activated and magnetic affinity cell-sorting
Med. Hypotheses
65
334-336
2005
Homo sapiens
Manually annotated by BRENDA team
Wang, Y.; Kasper, S.; Yuan, J.; Jin, R.J.; Zhang, J.; Ishii, K.; Wills, M.L.; Hayward, S.W.; Matusik, R.J.
Androgen-dependent prostate epithelial cell selection by targeting ARR2PBneo to the LPB-tag model of prostate cancer
Lab. Invest.
86
1074-1088
2006
Mus musculus
Manually annotated by BRENDA team
Shakya, T.; Wright, G.D.
Nucleotide selectivity of antibiotic kinases
Antimicrob. Agents Chemother.
54
1909-1913
2010
Enterococcus casseliflavus
Manually annotated by BRENDA team
Elizarov, S.M.; Alekseeva, M.G.; Novikov, F.N.; Chilov, G.G.; Maslov, D.A.; Shtil, A.A.; Danilenko, V.N.
Identification of phosphorylation sites in aminoglycoside phosphotransferase VIII from Streptomyces rimosus
Biochemistry (Moscow)
77
1258-1265
2012
Streptomyces rimosus, Streptomyces rimosus ATCC 10970
Manually annotated by BRENDA team
Leban, N.; Kaplan, E.; Chaloin, L.; Godreuil, S.; Lionne, C.
Kinetic characterization and molecular docking of novel allosteric inhibitors of aminoglycoside phosphotransferases
Biochim. Biophys. Acta
1861
3464-3473
2017
Enterococcus faecalis (P0A3Y5)
Manually annotated by BRENDA team
Das, A.; Shukla, A.; Thakur, S.; Rathore, M.; Singh, Narendra
Estimation of neomycin phosphotransferase-II (NPT-II) protein in vegetative and reproductive tissues of transgenic chickpea (Cicer arietinum L.) and biosafety perspectives
J. Plant Biochem. Biotechnol.
29
568-570
2020
Escherichia coli
-
Manually annotated by BRENDA team
Numata, K.; Horii, Y.; Motoda, Y.; Hirai, N.; Nishitani, C.; Watanabe, S.; Kigawa, T.; Kodama, Y.
Direct introduction of neomycin phosphotransferase II protein into apple leaves to confer kanamycin resistance
Plant Biotechnol.
33
403-407
2016
Escherichia coli
Manually annotated by BRENDA team