2.7.1.B19: geranylgeraniol kinase

This is an abbreviated version!
For detailed information about geranylgeraniol kinase, go to the full flat file.

Reaction

Synonyms

GGOH kinase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.B19 geranylgeraniol kinase

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Results	in table
1	Inhibitors
2	KM Value [mM]
1	Localization
5	Metals/Ions
1	Natural Substrates/ Products (Substrates)
1	Organism
2	Pathway
1	pH Optimum
1	Reaction
1	Reference
9	Substrates and Products (Substrate)
1	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 2.7.1.B19 - geranylgeraniol kinase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

ATP + (2E,6E)-farnesol

ADP + (2E,6E)-farnesyl phosphate

Sulfolobus acidocaldarius

-

7% of the activity compared to all-trans-geranylgeraniol. Activity is tested with membrane fraction washed with buffer to avoid contamination with soluble enzymes

719754

-

-

?

ATP + all-trans-hexaprenol

ADP + all-trans-hexaprenyl phosphate

Sulfolobus acidocaldarius

-

38% of the activity compared to all-trans-geranylgeraniol. Activity is tested with membrane fraction washed with buffer to avoid contamination with soluble enzymes

719754

-

-

?

ATP + all-trans-octaprenol

ADP + all-trans-octaprenyl phosphate

Sulfolobus acidocaldarius

-

24% of the activity compared to all-trans-geranylgeraniol. Activity is tested with membrane fraction washed with buffer to avoid contamination with soluble enzymes

719754

-

-

?

ATP + geranylgeraniol

ADP + geranylgeranyl phosphate

2 entries

CTP + geranylgeraniol

CDP + geranylgeranyl phosphate

Sulfolobus acidocaldarius

-

63% of the activity compared to ATP. Activity is tested with membrane fraction washed with buffer to avoid contamination with soluble enzymes

719754

-

-

?

GTP + geranylgeraniol

GDP + geranylgeranyl phosphate

Sulfolobus acidocaldarius

-

87% of the activity compared to ATP. Activity is tested with membrane fraction washed with buffer to avoid contamination with soluble enzymes

719754

-

-

?

UTP + geranylgeraniol

UDP + geranylgeranyl phosphate

Sulfolobus acidocaldarius

-

76% of the activity compared to ATP. Activity is tested with membrane fraction washed with buffer to avoid contamination with soluble enzymes

719754

-

-

?

additional information

?

-

Sulfolobus acidocaldarius

-

neither geraniol nor (22E,6E,10Z,14Z,18Z,22Z,26Z,30Z,34Z,38Z)-undecaprenol are active as substrates

719754

-

-

?

ATP + geranylgeraniol

ADP + geranylgeranyl phosphate

Sulfolobus acidocaldarius

-

all-trans-geranylgeraniol seems to be converted to its monophosphate in the membrane, and this product moves to the cytosol to undergo a second phosphorylation

719754

-

-

?

ATP + geranylgeraniol

ADP + geranylgeranyl phosphate

Sulfolobus acidocaldarius

-

all-trans-geranylgeraniol and ATP are the best substrates, activity is tested with membrane fraction washed with buffer to avoid contamination with soluble enzymes. No formation of geranylgeranyl diphosphate is observed

719754

-

-

?