2.7.2.1: acetate kinase
This is an abbreviated version!
For detailed information about acetate kinase, go to the full flat file.
Word Map on EC 2.7.2.1
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2.7.2.1
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phosphotransacetylase
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acetyl-coa
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cdc42
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methanosarcina
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thermophila
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sludge
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acetogenic
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cdc42-associated
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acetylphosphate
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formate-lyase
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non-receptor
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acetobutylicum
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substrate-level
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acetoin
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tyrobutyricum
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adp-forming
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phosphoketolase
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butyryl-coa
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embden-meyerhof-parnas
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acetate-activating
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synthesis
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industry
- 2.7.2.1
- phosphotransacetylase
- acetyl-coa
- cdc42
- methanosarcina
- thermophila
- sludge
-
acetogenic
-
cdc42-associated
- acetylphosphate
- formate-lyase
-
non-receptor
- acetobutylicum
-
substrate-level
- acetoin
- tyrobutyricum
-
adp-forming
- phosphoketolase
- butyryl-coa
-
embden-meyerhof-parnas
-
acetate-activating
- synthesis
- industry
Reaction
Synonyms
acetate kinase (phosphorylating), acetic kinase, acetokinase, ACK, ackA, AckA1, AckA2, ACKase, AK, ATP-ecoAK, ATP-specific AK, EAK, EutP, EutQ, MM_0495, Sak, short chain fatty acid kinase, StAckA, urkinase
ECTree
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Substrates Products
Substrates Products on EC 2.7.2.1 - acetate kinase
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REACTION DIAGRAM
ATP + ethanol
ADP + ethyl phosphate
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1% of reactivity with acetate
-
-
r
ATP + glycerol
ADP + glycerol phosphate
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1% of reactivity with acetate
-
-
r
ATP + glycine
ADP + glycyl phosphate
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1% of reactivity with acetate
-
-
r
ATP + heptanoate
ADP + heptyl phosphate
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22% activity compared to acetate
-
-
r
ATP + hexanoate
ADP + hexyl phosphate
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38% activity compared to acetate
-
-
r
ATP + octanoate
ADP + octyl phosphate
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8.4% activity compared to acetate
-
-
r
ATP + valerate
ADP + valeryl phosphate
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43.3% activity compared to acetate
-
-
r
acetyl hydroxamate + phosphate
-
-
-
?
acetyl phosphate + hydroxylamine
acetyl hydroxamate + phosphate
-
-
-
-
r
acetyl phosphate + hydroxylamine
acetyl hydroxamate + phosphate
-
-
-
r
acetyl phosphate + hydroxylamine
acetyl hydroxamate + phosphate
-
-
-
?
acetyl phosphate + hydroxylamine
acetyl hydroxamate + phosphate
-
-
-
?
acetyl phosphate + hydroxylamine
acetyl hydroxamate + phosphate
high-energy acetyl phosphate reacts with hydroxylamine forming acetyl hydroxamate and inorganic phosphate
-
-
?
ADP + acetyl phosphate
ATP + acetate
20fold more active in the reaction of acetate synthesis compared to acetate phosphorylation. The enzyme shows strong specificity to ATP and ADP
-
-
r
ADP + acetyl phosphate
ATP + acetate
20fold more active in the reaction of acetate synthesis compared to acetate phosphorylation. The enzyme shows strong specificity to ATP and ADP
-
-
r
ADP + acetyl phosphate
ATP + acetate
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-
-
-
r
ATP + acetate
ADP + acetyl phosphate
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acetate kinase/phosphotransacetylase, major role of this two-enzyme sequence is to provide acetyl coenzyme A which may participate in fatty acid synthesis, citrate formation and subsequent oxidation
-
r
ATP + acetate
ADP + acetyl phosphate
the equilibrium lies far to the left side
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-
r
ATP + acetate
ADP + acetyl phosphate
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-
r
ATP + acetate
ADP + acetyl phosphate
key enzyme and responsible for dephosphorylation of acetyl phosphate with the concomitant production of acetate and ATP
-
r
ATP + acetate
ADP + acetyl phosphate
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function in the metabolism of pyruvate or synthesis of acetyl-CoA coupling with phosphoacetyltransacetylase
-
r
ATP + acetate
ADP + acetyl phosphate
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function in the metabolism of pyruvate or synthesis of acetyl-CoA coupling with phosphoacetyltransacetylase
-
r
ATP + acetate
ADP + acetyl phosphate
acetate kinase is a key enzymes of acetate metabolism of anaerobes
-
-
?
ATP + acetate
ADP + acetyl phosphate
acetate kinase is a key enzymes of acetate metabolism of anaerobes
-
-
?
ATP + acetate
ADP + acetyl phosphate
-
function in the initial activation of acetate for conversion to methane and CO2
-
r
ATP + acetate
ADP + acetyl phosphate
catalytic mechanism, roles for the arginine residues Arg241 and Arg91 in transition state stabilization for catalysis but not in nucleotide binding determined, experimental evidence for domain motion
-
-
r
ATP + acetate
ADP + acetyl phosphate
the enzyme is proposed to function in the initial activation of acetate for conversion to methane and CO2
-
-
?
ATP + acetate
ADP + acetyl phosphate
activity in the reverse direction is 2.6fold greater than in the forward direction (acetate kinase activity)
-
-
r
ATP + acetate
ADP + acetyl phosphate
the wild type enzyme shows broad NTP utilization, with greater than 50% activity with CTP, GTP, TTP, UTP, and ITP versus ATP
-
-
?
ATP + acetate
ADP + acetyl phosphate
the enzyme is proposed to function in the initial activation of acetate for conversion to methane and CO2
-
-
?
ATP + acetate
ADP + acetyl phosphate
activity in the reverse direction is 2.6fold greater than in the forward direction (acetate kinase activity)
-
-
r
ATP + acetate
ADP + acetyl phosphate
the enzyme is 20fold more active in the reaction of acetate synthesis compared to acetate phosphorylation and shows strong specificity to ATP/ADP The enzyme has a remarkably high catalytic efficiency for acetate and ATP formation
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-
r
ATP + acetate
ADP + acetyl phosphate
20fold more active in the reaction of acetate synthesis compared to acetate phosphorylation. The enzyme shows strong specificity to ATP and ADP
-
-
r
ATP + acetate
ADP + acetyl phosphate
20fold more active in the reaction of acetate synthesis compared to acetate phosphorylation. The enzyme shows strong specificity to ATP and ADP
-
-
r
ATP + acetate
ADP + acetyl phosphate
the enzyme is 20fold more active in the reaction of acetate synthesis compared to acetate phosphorylation and shows strong specificity to ATP/ADP The enzyme has a remarkably high catalytic efficiency for acetate and ATP formation
-
-
r
ATP + acetate
ADP + acetyl phosphate
transcriptional control of the ackA gene
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-
?
ATP + acetate
ADP + acetyl phosphate
-
-
-
r
ATP + acetate
ADP + acetyl phosphate
-
-
-
-
r
ATP + acetate
ADP + acetyl phosphate
-
-
-
r
ATP + acetate
ADP + acetyl phosphate
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highest activity
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-
r
ATP + acetate
ADP + acetyl phosphate
enzyme assay developed that can measure the released phosphate at a nanomolar level
-
-
?
ADP + butyryl phosphate
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59.5% activity compared to acetate
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-
r
ATP + butyrate
ADP + butyryl phosphate
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2% of reactivity with acetate
-
-
r
ADP + formyl phosphate
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2% of reactivity with acetate
-
-
r
ATP + formate
ADP + formyl phosphate
-
-
-
?
ADP + isobutyryl phosphate
-
26.7% activity compared to acetate
-
-
r
ATP + propionate
ADP + propionyl phosphate
-
93.3% activity compared to acetate
-
-
r
ATP + propionate
ADP + propionyl phosphate
-
40% lower kinase activity than acetate
-
r
ATP + propionate
ADP + propionyl phosphate
-
40% lower kinase activity than acetate
-
r
ATP + propionate
ADP + propionyl phosphate
-
one-tenth of the rate shown with acetate
-
r
ATP + propionate
ADP + propionyl phosphate
-
poor acceptor, 5% relative to acetate at 500 mM
-
r
ATP + propionate
ADP + propionyl phosphate
-
poor acceptor, 5% relative to acetate at 500 mM
-
r
ATP + propionate
ADP + propionyl phosphate
the enzyme phosphorylates propionate at 60% of the rate with acetate
-
-
?
ATP + propionate
ADP + propionyl phosphate
-
-
-
?
CTP + acetate
CDP + acetyl phosphate
activity with TP is 53% of the activity with ATP
-
-
?
CTP + acetate
CDP + acetyl phosphate
50% of the activity relative to that observed with ATP
-
-
?
CTP + acetate
CDP + acetyl phosphate
-
-
-
?
GTP + acetate
GDP + acetyl phosphate
activity with TP is 79% of the activity with ATP
-
-
?
GTP + acetate
GDP + acetyl phosphate
85.2% of the activity relative to that observed with ATP
-
-
?
GTP + acetate
GDP + acetyl phosphate
activity with TP is 79% of the activity with ATP
-
-
?
GTP + acetate
GDP + acetyl phosphate
-
-
-
-
r
GTP + acetate
GDP + acetyl phosphate
-
-
-
?
ITP + acetate
IDP + acetyl phosphate
activity with TP is 83% of the activity with ATP
-
-
?
ITP + acetate
IDP + acetyl phosphate
80% of the activity relative to that observed with ATP
-
-
?
ITP + acetate
IDP + acetyl phosphate
activity with TP is 83% of the activity with ATP
-
-
?
ITP + acetate
IDP + acetyl phosphate
-
-
-
r
TTP + acetate
TDP + acetyl phosphate
activity with TP is 106% of the activity with ATP
-
-
?
TTP + acetate
TDP + acetyl phosphate
64.5% of the activity relative to that observed with ATP
-
-
?
UTP + acetate
UDP + acetyl phosphate
activity with TP is 80% of the activity with ATP
-
-
?
UTP + acetate
UDP + acetyl phosphate
54.8% of the activity relative to that observed with ATP
-
-
?
UTP + acetate
UDP + acetyl phosphate
-
-
-
?
?
-
-
UTP is no phosphate donor, lactate, succinate, maleate formate and bicarbonate are not acceptors
-
-
?
additional information
?
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-
UTP is no phosphate donor, lactate, succinate, maleate formate and bicarbonate are not acceptors
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-
?
additional information
?
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-
formate and butyrate are no substrates
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-
?
additional information
?
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-
neither propionic acid nor butyric acid are active as substrates
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-
?
additional information
?
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-
formate, butyrate and various holo and hydroxy derivatives of acetate and propionate are not phosphorylated
-
-
?
additional information
?
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-
UTP and CTP are active only partially
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-
?
additional information
?
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-
formate is no substrate
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-
?
additional information
?
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-
UTP and CTP are active only partially
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-
?
additional information
?
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the enzyme is unable to use formate
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-
?
additional information
?
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-
the enzyme is unable to use formate
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-
?
additional information
?
-
the enzyme is unable to use formate
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-
?
additional information
?
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-
not active toward formate, butyrate, valerate and succinate
-
-
?
additional information
?
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-
neither propionic acid nor butyric acid are active as substrates
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-
?
additional information
?
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no activity with AMP-PCP, CTP or TTP
-
-
-
additional information
?
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-
isobutyrate, isovalerate, 2-methylbutyrate, butyrate and valerate are no substrates
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-
?
additional information
?
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-
isobutyrate, isovalerate, 2-methylbutyrate, butyrate and valerate are no substrates
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-
?
additional information
?
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-
butyrate, isobutyrate, valerate and isovalerate are no substrates
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-
?
additional information
?
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-
enzyme does not react with malate, maleate, bicarbonate, butyrate, tartrate, citrate, formate or succinate
-
-
?