2.7.2.2: carbamate kinase
This is an abbreviated version!
For detailed information about carbamate kinase, go to the full flat file.
Word Map on EC 2.7.2.2
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2.7.2.2
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ornithine
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deiminase
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dihydrolase
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citrulline
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transcarbamoylase
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carbamyltransferase
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arcabc
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n-acetyl-l-glutamate
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drug development
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degradation
- 2.7.2.2
- ornithine
- deiminase
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dihydrolase
- citrulline
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transcarbamoylase
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carbamyltransferase
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arcabc
- n-acetyl-l-glutamate
- drug development
- degradation
Reaction
Synonyms
ACK, anabolic carbamyl kinase, ArcC, carbamate kinase, carbamoyl phosphokinase, carbamyl phosphokinase, catabolic carbamyl kinase, Cbk, CCK, CK, CK-like CPS, CKase, GlcK, kinase, carbamate (phosphorylating), putrescine synthase
ECTree
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General Information
General Information on EC 2.7.2.2 - carbamate kinase
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metabolism
physiological function
additional information
carbamate kinase catalyzes the last step of the essential L-arginine pathway, converting ADP and carbamoyl phosphate to ATP and ammonium carbamate
metabolism
the enzyme catalyzes the final step in the arginine dihydrolase pathway converting ADP and carbamoyl phosphate to ATP and carbamate
metabolism
the enzyme is part of the the arginine deiminase system, overview
metabolism
carbamoyl-phosphate synthetase and ornithine carbamoyltransferase form an efficient channeling cluster for carbamoyl phosphate, an extremely thermolabile and potentially toxic metabolic intermediate. Therefore, by physically interacting with each other, carbamoyl-phosphate synthetase and ornithine carbamoyltransferase prevent the thermodenaturation of carbamoyl phosphate in the aqueous cytoplasmic environment
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physically interacting with each other, carbamate kinase and ornithine carbamoyltransferase prevent thermodenaturation of carbamoyl phosphate (a precursor of pyrimidines and arginine, which is an extremely labile and potentially toxic intermediate) in the aqueous cytoplasmic environment. The carbamoyl phosphate channelling complex involves carbamate kinase, ornithine carbamoyltransferase and aspartate carbamoyltransferase
physiological function
carbamate kinase is an essential Giardia lamblia enzyme
physiological function
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physically interacting with each other, carbamate kinase and ornithine carbamoyltransferase prevent thermodenaturation of carbamoyl phosphate (a precursor of pyrimidines and arginine, which is an extremely labile and potentially toxic intermediate) in the aqueous cytoplasmic environment. The carbamoyl phosphate channelling complex involves carbamate kinase, ornithine carbamoyltransferase and aspartate carbamoyltransferase
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mdelling of the environment of Cys242 superposed in three conformational states, the AMP-PNP bound structure, the citric acid bound structure, and the thiocarbamoylated structure, overview. Modification of Cys242 interferes with the conformational transition that accompanies nucleotide binding, whereas the citric acid binding remains unaltered and the auxiliary domain is in the closed conformation
additional information
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mdelling of the environment of Cys242 superposed in three conformational states, the AMP-PNP bound structure, the citric acid bound structure, and the thiocarbamoylated structure, overview. Modification of Cys242 interferes with the conformational transition that accompanies nucleotide binding, whereas the citric acid binding remains unaltered and the auxiliary domain is in the closed conformation