Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.7.2.3: phosphoglycerate kinase

This is an abbreviated version!
For detailed information about phosphoglycerate kinase, go to the full flat file.

Word Map on EC 2.7.2.3

Reaction

ATP
+
3-phospho-D-glycerate
=
ADP
 +
3-phospho-D-glyceroyl phosphate

Synonyms

3-PGK, 3-phosphoglycerate 1-phosphotransferase, 3-phosphoglycerate kinase, 3-phosphoglycerate phosphokinase, 3-phosphoglyceric acid kinase, 3-phosphoglyceric acid phosphokinase, 3-phosphoglyceric kinase, AbPGK, ATP-3-phospho-D-glycerate-1-phosphotransferase, ATP:3-phospho-D-glycerate 1-phosphotransferase, ATP:D-3-phosphoglycerate 1-phosphotransferase, chl-PGK, glycerate 3-phosphate kinase, glycerophosphate kinase, HacPGK1, HacPGK2, HapPGK, hPGK, HsPGK, human 3-phosphoglycerate kinase, kinase (phosphorylating), phosphoglycerate, Mfer_0156, OsPGK2, P-glycerate kinase, PAS-PGK, PfPGK, PGK, PGK 1, PGK-1, PGK-2, pgk-B, PGK1, PGK2, Pgk3, Pgk5, PGKA, PGKase-1, PGKB, PGKC, pgkp1, pgkp2, phosphoglycerate kinase, phosphoglycerate kinase 1, phosphoglycerate kinase 2, phosphoglycerate kinase B, phosphoglycerate kinase-1, phosphoglyceric acid kinase, phosphoglyceric kinase, phosphoglycerokinase, PwPGK, SjPGK, SSO0527, testis-specific phosphoglycerate kinase 2, TRSC58_02767, X chromosome-linked phosphoglycerate kinase-1

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.2 Phosphotransferases with a carboxy group as acceptor
                2.7.2.3 phosphoglycerate kinase

Expression

Expression on EC 2.7.2.3 - phosphoglycerate kinase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
considerable downregulation of PGK1 expression in siPGK1-treated cells compared to control cells
-
CXCR4 regulates the expression of PGK1. Overexpression of PGK1 in patients with development of peritoneal carcinomatosis
-
expression of OsPGK2 in cv. IR64 is induced late, i.e., from 48 h of salinity stress till 96 h. In contrast, in case of landrace Pokkali, its expression is seen at a very basal level even in control samples which shows a continuous increase up to 96 h of salinity stress. High levels of OsPGK2 protein are detected in shoots of Pokkali even under non-stress conditions while the salinity-sensitive cv. IR64 does not show detectable levels even after 24 h of salinity stress
HacPGK1 shows the highest level of expression during seed development, especially at the initial stages, 12 days after flowering (DAF), and accounts for most (approximately 89%) of the combined expression of the three genes. As seed development progresses, the level of expression for this gene decreases
-
highest expression of HapPGK in photosynthetically active tissues, cotyledons and leaves
-
in culture, hypoxic treatment induces protein expression of PGK by 3fold but has no effect on the protein expression of other beta-L-dioxolane-cytidine metabolism-associated enzymes such as apurinic/apyrimidinic endonuclease-1, deoxycytidine kinase, CMP kinase, and nM23 H1. Expression of PGK increases as the tumor size increases. PGK protein expression has a positive correlation to HIF-1alpha
-
in the cytoplasm of early meiotic spermatocytes, t-KSRP promotes the decay of Pgk2 mRNA
-
PGK1 expression is upregulated in cancer-associated fibroblasts versus normal fibroblasts derived from the prostate peripheral zone. Overexpression of CXCL12 in normal fibroblasts and cancer-associated fibroblasts enhances secretion of PGK1 compared with controls
-
Pgk2 mRNA is first detectable in early meiosis in spermatocytes and increases dramatically in spermatids. Decline of t-KSRP in late meiosis and increase of PTBP2 are concomitant with the increase in Pgk2 mRNA levels
-
reduced CXCL12 expression inhibits PGK1 expression by cancer-associated fibroblasts
-
spermatozoa from elderly men and young asthenozoospermia patients show decreased expression of phosphoglycerate kinase 2