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2.7.2.4: aspartate kinase

This is an abbreviated version!
For detailed information about aspartate kinase, go to the full flat file.

Word Map on EC 2.7.2.4

Reaction

ATP
+
L-aspartate
=
ADP
 +
4-phospho-L-aspartate

Synonyms

AK, AK II, AK III, AK-HSDH, AK-HSDH I, AK-HSDH1, AK-HSDH2, AK-HseDH, AK-R7, AK-ts31d, AK1, AK2, AK3, AKbeta, AKII, AKIII, AKsyn, Ask, ASK1, ASK2, Ask_Ect, Ask_LysC, Asp kinase-homoserine dehydrogenase, aspartate kinase, aspartate kinase (phosphorylating), aspartate kinase 1, aspartate kinase 2, aspartate kinase 3, aspartate kinase beta, aspartate kinase I, aspartate kinase II, aspartate kinase III, aspartic kinase, aspartokinase, aspartokinase 1-homoserine dehydrogenase 1, aspartokinase 2, aspartokinase 3, aspartokinase I, aspartokinase II, aspartokinase III, aspartokinase-homoserine dehydrogenase, beta-aspartokinase, bifunctional aspartate kinase-homoserine dehydrogenase, BT, BTT, CgAK, dap-aspartokinase, HOM3 product, HOM3-R7 product, HOM3-ts31d product, HseDH, LT-aspartokinase, lysC, lysine-sensitive aspartokinase 3, More, MtbAKbeta, nspJ, Thr-sensitive aspartate kinase, thrA, thrA1, thrA2, TM_0547, XbAK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.2 Phosphotransferases with a carboxy group as acceptor
                2.7.2.4 aspartate kinase

Specific Activity

Specific Activity on EC 2.7.2.4 - aspartate kinase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00096
-
thrA2, in the presence of L-lysine
0.0013
-
mutant S2207A
0.0064
-
wild-type
0.0068
-
mutant RL4
0.0107
-
complemented mutant A2207A/pM1-1
0.0268
-
wild type X-2180-1A
0.08
at 37°C culture temperature and 22°C assay temperature
0.09
at 22°C culture temperature and 22°C assay temperature
0.11
in the presence of 20 mM threonine
0.16
at 37°C culture temperature and 22°C assay temperature
0.196
-
thrA2, in the presence of L-threonine
0.2
at 22°C culture temperature and 22°C assay temperature
0.21
at 37°C culture temperature and 37°C assay temperature
0.26
at 22°C culture temperature and 22°C assay temperature
0.27
at 22°C culture temperature and 37°C assay temperature
0.289
-
thrA2, in the presence of L-isoleucine
0.29
-
thrA2, in the presence of L-methionine
0.36
at 37°C culture temperature and 37°C assay temperature
0.38
-
truncated protein, which contains only the N-terminal region
0.39
at 22°C culture temperature and 37°C assay temperature
0.4
at 22°C culture temperature and 37°C assay temperature
0.488
in the presence of 20 mM threonine
0.51
at 37°C culture temperature and 22°C assay temperature
1.12
at 37°C culture temperature and 37°C assay temperature
10.6
glutathione-S-transferase fusion protein, 37°C assay temperature
103
purified recombinant enzyme, pH 7.5, 55°C
18.87
reverse reaction
39.05
-
activity after the final purification step
45.6
GST-fusion protein, 37°C assay temperature
5.6
glutathione-S-transferase fusion protein, 22°C assay temperature
5.9
-
wild type
52.2
GST-fusion protein, 22°C assay temperature
additional information