2.7.2.4: aspartate kinase
This is an abbreviated version!
For detailed information about aspartate kinase, go to the full flat file.
Word Map on EC 2.7.2.4
-
2.7.2.4
-
corynebacterium
-
glutamicum
-
threonine-sensitive
-
l-lysine
-
l-threonine
-
dihydrodipicolinate
-
i-homoserine
-
diaminopimelate
-
semialdehyde
-
feedback-resistant
-
aspartate-derived
-
feedback-insensitive
-
aec
-
l-isoleucine
-
s-2-aminoethyl-l-cysteine
-
lysine-producing
-
flavum
-
thialysine
-
meso-diaminopimelate
-
ectoine
-
synthesis
-
agriculture
-
medicine
-
nutrition
-
food industry
- 2.7.2.4
- corynebacterium
- glutamicum
-
threonine-sensitive
- l-lysine
- l-threonine
- dihydrodipicolinate
-
i-homoserine
- diaminopimelate
- semialdehyde
-
feedback-resistant
-
aspartate-derived
-
feedback-insensitive
- aec
- l-isoleucine
- s-2-aminoethyl-l-cysteine
-
lysine-producing
- flavum
- thialysine
- meso-diaminopimelate
- ectoine
- synthesis
- agriculture
- medicine
- nutrition
- food industry
Reaction
Synonyms
AK, AK II, AK III, AK-HSDH, AK-HSDH I, AK-HSDH1, AK-HSDH2, AK-HseDH, AK-R7, AK-ts31d, AK1, AK2, AK3, AKbeta, AKII, AKIII, AKsyn, Ask, ASK1, ASK2, Ask_Ect, Ask_LysC, Asp kinase-homoserine dehydrogenase, aspartate kinase, aspartate kinase (phosphorylating), aspartate kinase 1, aspartate kinase 2, aspartate kinase 3, aspartate kinase beta, aspartate kinase I, aspartate kinase II, aspartate kinase III, aspartic kinase, aspartokinase, aspartokinase 1-homoserine dehydrogenase 1, aspartokinase 2, aspartokinase 3, aspartokinase I, aspartokinase II, aspartokinase III, aspartokinase-homoserine dehydrogenase, beta-aspartokinase, bifunctional aspartate kinase-homoserine dehydrogenase, BT, BTT, CgAK, dap-aspartokinase, HOM3 product, HOM3-R7 product, HOM3-ts31d product, HseDH, LT-aspartokinase, lysC, lysine-sensitive aspartokinase 3, More, MtbAKbeta, nspJ, Thr-sensitive aspartate kinase, thrA, thrA1, thrA2, TM_0547, XbAK
ECTree
2.7.2.4 aspartate kinaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.7.2.4 - aspartate kinase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + DL-threo-3-methyl aspartate
ADP + 3-methyl-4-phosphoaspartate
-
aspartokinase III
-
-
?
ATP + L-aspartic acid amide
ADP + 4-phospho-L-aspartic acid amide
-
aspartokinase III
-
-
?
ATP + N-acetyl-L-aspartate
ADP + N-acetyl-4-phospho-L-aspartate
-
aspartokinase III
-
-
?
ATP + N-chloroacetyl-L-aspartate
ADP + N-chloroacetyl-4-phospho-L-aspartate
-
aspartokinase III
-
-
?
ATP + N-formyl-L-aspartate
ADP + N-formyl-4-phospho-L-aspartate
-
aspartokinase III
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
first and third step of the synthesis of methionine, catalyzed by a bifunctional enzyme
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
first step of a branched biosynthetic pathway for L-lysine, L-threonine, L-isoleucine and L-methionine, regulated by the end products through feedback inhibition, the 3 aspartate kinases I, II and II are regulated by different end products
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
physiological role of aspartokinase II is to supply precursors for the amino acid pool
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
first specific step in the biosynthesis of L-lysine, L-threonine and L-methionine
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
first specific step in the biosynthesis of L-lysine, L-threonine and L-methionine
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
-
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
first step common to the biosynthesis of L-lysine, L-threonine, isoleucine and methionine
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
transfer of the gamma-phosphate group of ATP to aspartate, substrate binding site structures, overview
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
-
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
-
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
disruption analyes of Deinococcus radiodurans AK indicates that the AK is not used for lysine biosynthesis, but for threonine and methionine biosyntheses
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539
disruption analyes of Deinococcus radiodurans AK indicates that the AK is not used for lysine biosynthesis, but for threonine and methionine biosyntheses
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
maximum velocity of the reverse reaction is only one-twelfth that of the forward reaction, but has the advantage of using commercial substrates
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
first step in the branched biosynthetic pathway for the synthesis of L-lysine, L-methionine, L-threonine, L-isoleucine and diaminopimelic acid
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
part of the aspartate pathway of amino acid biosynthesis
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
aspartate kinase activity
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
Escherichia coli B / ATCC 11303
-
first step in the branched biosynthetic pathway for the synthesis of L-lysine, L-methionine, L-threonine, L-isoleucine and diaminopimelic acid
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
-
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
-
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
first and key enzyme of the aspartate pathway leading to the biosynthesis of essential amino acids L-lysine and L-threonine
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
branched pathway for biosynthesis of isoleucine, threonine, homoserine, methionine and lysine
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
L-aspartate binds to this recombinant enzyme in two different orientations
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
first enzyme of aspartic acid metabolic pathway, leads to synthesis of lysine, threonine, methionine and isoleucine
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
first step common to the biosynthesis of L-lysine, L-threonine, isoleucine and methionine
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
first step in the branched pathway leading to synthesis of threonine and methionine from aspartate
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
-
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
first step of the branched biosynthetic pathway for lysine, threonine, isoleucine and methionine
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
first step common to the biosynthesis of L-lysine, L-threonine, isoleucine and methionine
-
r
ATP + L-aspartate
ADP + phospho-L-aspartate
-
-
-
-
?
ATP + L-aspartate
ADP + phospho-L-aspartate
-
-
-
-
?
ATP + L-aspartate
ADP + phospho-L-aspartate
-
maximum activity is achieved with 12.5 mM MgSO4 and 20 mM ATP
-
-
?
additional information
?
-
-
aspartokinase III, D-isomers of the derivatives of aspartic acid, including D-aspartate alpha-benzyl ester and D-aspartate beta-hydroxamate are not substrates regardless of whether the alpha- or the beta-carboxyl group is derivatized, L-cysteine sulfinate and 2-methyl-DL-aspartate are no substrates
-
-
?
additional information
?
-
the bifunctional enzyme also exhibits L-homoserine dehydrogenase activity, EC 1.1.1.3
-
-
-
additional information
?
-
the bifunctional enzyme also exhibits L-homoserine dehydrogenase activity, EC 1.1.1.3
-
-
-
additional information
?
-
-
no other natural aminoacids or D-aspartate are substrates of this reaction
-
-
?
additional information
?
-
-
aspartate analogues succinate, maleate, L-glutamate and DL-2-amino-3-phosphonopropionate have no influence on the reaction
-
-
?
additional information
?
-
-
absolute requirement for ATP, no other nucleoside phosphates serve as phosphate donor, analogs of aspartate such as L-glutamate, DL-alpha-methyl aspartate, N-acetyl aspartate and D-aspartate are inactive as acceptors
-
-
?
additional information
?
-
-
D-aspartate, L-glutamate and beta-alanine are inactive as substitutes for L-aspartate in the forward reaction, in the reverse reaction ADP cannot be replaced by AMP, UDP, GDP or IDP
-
-
?
additional information
?
-
-
strict requirement for ATP as a phosphorylating agent, CTP and GTP are not active
-
-
?
additional information
?
-
-
strict requirement for ATP as a phosphorylating agent, CTP and GTP are not active
-
-
?
additional information
?
-
-
the bifunctional enzyme also exhibits L-homoserine dehydrogenase activity, EC 1.1.1.3. It shows substantial activities of both aspartate kinase (AK) and homoserine dehydrogenase (HseDH)
-
-
-
additional information
?
-
the bifunctional enzyme also exhibits L-homoserine dehydrogenase activity, EC 1.1.1.3. It shows substantial activities of both aspartate kinase (AK) and homoserine dehydrogenase (HseDH)
-
-
-
additional information
?
-
the bifunctional enzyme also exhibits L-homoserine dehydrogenase activity, EC 1.1.1.3. It shows substantial activities of both aspartate kinase (AK) and homoserine dehydrogenase (HseDH)
-
-
-
additional information
?
-
the bifunctional enzyme also exhibits L-homoserine dehydrogenase activity, EC 1.1.1.3. It shows substantial activities of both aspartate kinase (AK) and homoserine dehydrogenase (HseDH)
-
-
-
additional information
?
-
the bifunctional enzyme also exhibits L-homoserine dehydrogenase activity, EC 1.1.1.3. It shows substantial activities of both aspartate kinase (AK) and homoserine dehydrogenase (HseDH)
-
-
-
additional information
?
-
-
no reaction observed with ITP, CTP or UTP
-
-
?
