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2.7.3.2: creatine kinase

This is an abbreviated version!
For detailed information about creatine kinase, go to the full flat file.

Word Map on EC 2.7.3.2

Reaction

ATP
+
Creatine
=
ADP
 +
phosphocreatine

Synonyms

adenosine triphosphate-creatine transphosphorylase, adenosine-5'-triphosphate: creatine phosphotransferase, ATP-creatine transphosphorylase, ATP: creatine N-phosphotransferase, ATP:creatine phosphotransferase, B-type creatine kinase, BB-CK, BB-type creatine kinase, BCK, brain creatine kinase, brain type creatine kinase, brain-type CK, brain-type creatine kinase, CK, CK MM, CK-B, CK-BB, CK-MB, CK-MM, ckb, CKM, CKMB, CKMBI, CKMiMi, creatine kinase, creatine kinase B, creatine kinase M-type, creatine kinase MB, creatine kinase muscle type, creatine kinase-MB, creatine N-phosphotransferase, creatine phosphokinase, creatine phosphotransferase, creatinine kinase, creatinine kinase MB, hBBCK, hMMCK, kinase, creatine (phosphorylating), M-CK, M1-CK, MB-CK, MCK, Mi-CK, MiMi-CK, mit-CK, mitochondrial creatine kinase, MM-CK, MM-type creatine kinase, More, MtCK, muscle creatine kinase, muscle type creatine kinase, muscle-type creatine kinase, phosphocreatine kinase, plasma creatine kinase, PSCKM, recombinant human brain-type creatine kinase, rHBCK, RM-CK, s-type CK, sarcomeric CK, sMiCK, sMtCK, u-type CK, ubiquitous CK, ubiquitous MtCK, uMiCK, uMtCK, zMMCK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.3 Phosphotransferases with a nitrogenous group as acceptor
                2.7.3.2 creatine kinase

Crystallization

Crystallization on EC 2.7.3.2 - creatine kinase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure analysis of muscle cytosolic isozyme
-
isozyme MM-CK
-
overview: electron microscopy, X-ray crystallography
isozyme MM-CK
-
a dimeric and a octameric isoform
-
brain-type isoform
-
crystal structure analysis of the cytosolic brain isozyme, and of the cardiac sarcomeric mitochondrial crystallized free or bound to MgATP or transition state analogue complex
overview: electron microscopy, X-ray crystallography
-
crystal structure analysis of muscle-type cytosolic isozyme, and of ubiquitous mitochondrial isozyme, and of cytosolic brain type isozyme
-
crystallized at 22°C using PEG 4000 as a precipitant. X-ray diffraction data are collected to 2.2 A resolution using synchrotron radiation. The crystals belong to the tetragonal space group P4(3)2(1)2, with cell parameters of a = b = 97.963, c = 164.312 A, and alpha = beta = gamma = 90°. The symmetric unit contains two molecules of creatine kinase
-
isozyme MiMi-CK
-
muscle isoform
-
overview: electron microscopy, X-ray crystallography
-
ubiquituos mitochondrial isoform
-
crystal structure analysis of muscle cytosolic isozyme
-
crystals of the mutant G268N are successfully raised to study the fine structural change around the active site. Results show that one residue mutation in can cause the mutant G268N to exhibit cold-adapted enzyme properties comparable to those of Cyprinus carpio M1-creatine kinase
-
muscle isoform
-
NMR screening of inhibitors docked to the crystal structure of enzyme. A phenylfuroic acid may enter into a pocket adjacent to the nucleotide binding site
-
overview: electron microscopy, X-ray crystallography
-
structure of mutant R134K in a transition-state analogue complex. The functional enzyme dimer shows significant structural asymmetry with one monomer in a closed conformation with the active site occupied by the transition-state analogue components craetine, MgADP and nitrate. The other monomer has the two loops that control access to the active site in an open conformation and only MgADP is bound
overview: electron microscopy, X-ray crystallography
crystal structure analysis of muscle-type cytosolic isozyme crystallized with transition state analogue complex
-
in complex with a transistion-state analog
-