2.7.3.3: arginine kinase

This is an abbreviated version!
For detailed information about arginine kinase, go to the full flat file.

Reaction

Synonyms

adenosine 5'-triphosphate-arginine phosphotransferase, adenosine 5'-triphosphate: L-arginine phosphotransferase, AK, AK-1, AK1, AK2, AK3, AK4, AK: L-arginine phosphotransferase, arginine kinase 1, arginine kinase 2, arginine kinase-1, arginine phosphokinase, ArgK, ARGK-2, ark, ATP: arginine N-phosphotransferase, ATP: arginine phosphotransferase, ATP: L-arginine phosphototransferase, ATP: L-arginine phosphotransferase, ATP:arginine N-phosphotransferase, ATP:arginine phosphotransferase, ATP:L-arginine N-phosphotransferase, ATP:L-arginine omega-N-phosphotransferase, ATP:L-arginine phosphotransferase, ESAK, F32B5.1, F44G3.2, F46H5.3, kinase, arginine (phosphorylating), McsB, MnAK2, MXAN2252 protein, PyAK1, PyAK2, PyAK3, PyAK4, rDer p 20, Tb09.160.4560, Tb927.9.6170, TbAK2, TbAK3, TcAK, TcAK1, TcAK2, W10C8.5, ZC434.8

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.3 Phosphotransferases with a nitrogenous group as acceptor

                2.7.3.3 arginine kinase

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Results	in table
11	Activating Compound
10670	AA Sequence
48	Application
1	CAS Registry Number
77	Cloned(Commentary)
51	Cofactor
13	Crystallization (Commentary)
20	Expression
55	General Information
9	General Stability
2	IC50 Value
129	Inhibitors
31	kcat/KM [mM/s]
34	Ki Value [mM]
315	KM Value [mM]
19	Localization
82	Metals/Ions
93	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
3	Organic Solvent Stability
233	Organism
1	Pathway
38	PDB ID
51	pH Optimum
18	pH Range
8	pH Stability
25	pI Value
3	Posttranslational Modification
121	Protein Variants
77	Purification (Commentary)
6	Reaction
1	Reaction Type
218	Reference
7	Renatured (Commentary)
196	Source Tissue
22	Specific Activity [micromol/min/mg]
8	Storage Stability
208	Substrates and Products (Substrate)
64	Subunits
90	Synonyms
1	Systematic Name
21	Temperature Optimum [°C]
7	Temperature Range [°C]
25	Temperature Stability [°C]
206	Turnover Number [1/s]

Temperature Stability

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of the Enzyme Summary Page.

Temperature Stability on EC 2.7.3.3 - arginine kinase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

20

2 entries

25

2 entries

30

2 entries

30 - 40

Amphioctopus fangsiao

-

the enzyme is relatively stable below 30°C, but the original bands become faint and the bands of aggregated enzyme (above 70 kDa) appear when the temperature is above 40°C

722436

30 - 44

Procambarus clarkii

H6VGI2

stable at, crayfish arginine kinase easily forms aggregates at temperatures above 44°C

738275

35

Paracentrotus lividus

-

10 min, stable

642449

40

4 entries

45

2 entries

45 - 65

2 entries

46 - 60

Apostichopus japonicus

-

the activity of wild type enzyme changes a little after heat treatment for 10 min at temperatures below 45°C. A steep decrease of activity is observed after 10 min between 45 and 60°C, and a complete loss of activity occurs above 65°C. The midpoint of thermal inactivation of wild type enzyme is at about 52°C

721428

5 - 50

Euphausia superba

-

purified enzyme, activity is relatively stable from 5°C to 23°C, but decreases rapidly from 25°C to 40°C. The activity is almost abolished at 50°C, half -life at 31.88°C

739565

50

2 entries

55

Drosophila melanogaster

-

10 min, complete loss of activity

642454

additional information

3 entries

20

Penaeus japonicus

-

10 min, stable up to

642448

20

Portunus trituberculatus

-

10 min, stable up to

642448

25

Penaeus japonicus

-

10 min, inactivation above

642448

25

Portunus trituberculatus

-

10 min, inactivation above

642448

30

Homarus gammarus

-

pH 8.5, 3 h, stable

642456

30

Locusta migratoria manilensis

-

10 min, wild-type enzyme, and mutant enzymes P272D, P272G and P272R are stable

687138

40

Locusta migratoria manilensis

-

10 min, wild-type enzyme loses about 10% of its activity, mutant enzyme P272D loses about 30% of its activity, mutant enzyme P272G loses about 25% of its activity and mutant enzyme P272R loses about 35% of its activity

687138

40

Paracentrotus lividus

-

10 min, 21% loss of activity

642449

40

Penaeus japonicus

-

10 min, 100 mM Tris-HCl buffer, pH 8.0, 15% loss of activity. 10 min, 100 mM Tris-HCl buffer, pH 7.0, 16% loss of activity

642448

40

Portunus trituberculatus

-

10 min, 100 mM Tris-HCl buffer, pH 8.0, 34% loss of activity. 10 min, 100 mM Tris-HCl buffer, pH 7.0, 46% loss of activity

642448

45

Drosophila melanogaster

-

10 min, stable up to

642454

45

Paracentrotus lividus

-

inactivation

642449

45 - 65

Locusta migratoria manilensis

-

the wild type enzyme can retain its activity well at temperatures lower than 48°C, and then its activity shows a steep decrease from 45 to 60°C and completely loses its activity at temperatures above 65°C. The melting temperature is at about 56°C

722402

45 - 65

Locusta migratoria manilensis

A6M9J4

the wild type enzyme retains its activity well at temperatures lower than 48°C, and then its activity shows a steep decrease from 45 to 60°C and completely loses its activity at temperatures above 65°C

722403

50

Locusta migratoria manilensis

-

10 min, wild-type enzyme loses about 40% of its activity, mutant enzyme P272D loses about 90% of its activity, mutant enzyme P272G loses about 85% of its activity and mutant enzyme P272R loses about 90% of its activity

687138

50

Periplaneta americana

-

10 min, 50% loss of activity

660821

additional information

Euphausia superba

-

thermal denaturation directly induced ESAK aggregation, glycine, proline and glycerol not only prevent enzyme ESAK from inactivation and unfolding but also inhibit aggregation by stabilizing the enzyme conformation. Evaluation of the inactivation kinetics and rate constants, calculation of the transition free energy

739565

additional information

Molpadia arenicola

-

unstable to heat

642458

additional information

Phormia regina

-

unstable to heat

642459