2.7.3.9: phosphoenolpyruvate-protein phosphotransferase
This is an abbreviated version!
For detailed information about phosphoenolpyruvate-protein phosphotransferase, go to the full flat file.
Word Map on EC 2.7.3.9
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2.7.3.9
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hpr
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phosphocarrier
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fructose
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permease
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streptococcus
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catabolite
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histidine-containing
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typhimurium
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mannitol
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lactose
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glucose-specific
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non-pts
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iiiglc
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antiterminator
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unphosphorylated
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mutans
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mannitol-specific
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histidyl
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cellobiose
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2-deoxyglucose
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alpha-glucoside
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casei
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salivarius
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melibiose
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energy-coupling
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beta-glucoside
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pep-dependent
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fructose-specific
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eiias
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medicine
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starch-branching
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glucitol
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drug development
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nonmetabolizable
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dikinase
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transphosphorylation
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carnosus
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capricolum
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hexitols
- 2.7.3.9
- hpr
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phosphocarrier
- fructose
-
permease
- streptococcus
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catabolite
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histidine-containing
- typhimurium
- mannitol
- lactose
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glucose-specific
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non-pts
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iiiglc
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antiterminator
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unphosphorylated
- mutans
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mannitol-specific
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histidyl
- cellobiose
- 2-deoxyglucose
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alpha-glucoside
- casei
- salivarius
- melibiose
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energy-coupling
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beta-glucoside
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pep-dependent
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fructose-specific
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eiias
- medicine
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starch-branching
- glucitol
- drug development
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nonmetabolizable
- dikinase
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transphosphorylation
- carnosus
- capricolum
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hexitols
Reaction
Synonyms
EIC, EIN, enzyme I, enzyme I of the phosphotransferase system, More, non-sugar-specific phosphotransferase, PEP:sugar phosphotransferase system enzyme I, PEP:sugar PT, phosphoenolpyruvate protein phosphotransferase, phosphoenolpyruvate sugar phosphotransferase enzyme I, phosphoenolpyruvate-dependent phosphotransferase, phosphoenolpyruvate-dependent phosphotransferase system, phosphoenolpyruvate-dependent phosphotransferase system enzyme I, phosphoenolpyruvate-protein phosphotransferase, phosphoenolpyruvate:carbohydrate phosphotransferase system, phosphoenolpyruvate:glucose/mannose phosphotransferase system, phosphoenolpyruvate:glycose phosphotransferase system, phosphoenolpyruvate:glycose phosphotransferase system enzyme I, phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase, phosphoenolpyruvate:sugar phosphotransferase, phosphoenolpyruvate:sugar phosphotransferase system, phosphopyruvate-protein factor phosphotransferase, phosphopyruvate-protein phosphotransferase, phosphotransferase enzyme I, phosphotransferase system component enzyme I, phosphotransferase system enzyme I, phosphotransferase, phosphoenolpyruvate-protein, protein kinase enzyme I, PTS, ptsA, ptsI, sugar-PEP phosphotransferase enzyme I, YpqE
ECTree
2.7.3.9 phosphoenolpyruvate-protein phosphotransferaseAdvanced search results
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Engineering on EC 2.7.3.9 - phosphoenolpyruvate-protein phosphotransferase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C502A
Caldanaerobacter subterraneus subsp. tengcongensis DSM 15242 / JCM 11007 / NBRC 100824 / MB4
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active site mutant
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H189A
Caldanaerobacter subterraneus subsp. tengcongensis DSM 15242 / JCM 11007 / NBRC 100824 / MB4
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active site mutant
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G356S
the mutant shows reduced dimerization affinity and lower autophosphorylation activity compared to the wild type enzyme
H189A
H189E
H186D
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the phosphomimetic mutant of the N-terminal domain of enzyme I shows reduced thermal stability compared to the wild type enzyme
additional information
additional information
replacement of HPr and EI of Escherichia coli with the homologous proteins from Bacillus subtilis, a gram-positive bacterium, leads to severe growth defects on PTS sugars, suggesting that HPr of Bacillus subtilis cannot efficiently phosphorylate the EIIs of Escherichia coli, enhanced phosphorylation is achieved with Bacillus subtilis HPr mutants, overview
additional information
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replacement of HPr and EI of Escherichia coli with the homologous proteins from Bacillus subtilis, a gram-positive bacterium, leads to severe growth defects on PTS sugars, suggesting that HPr of Bacillus subtilis cannot efficiently phosphorylate the EIIs of Escherichia coli, enhanced phosphorylation is achieved with Bacillus subtilis HPr mutants, overview
additional information
replacement of HPr and enzyme I of Escherichia coli with the homologous proteins from Bacillus subtilis, a gram-positive bacterium, leads to severe growth defects on PTS sugars, suggesting that HPr of Bacillus subtilis cannot efficiently phosphorylate the enzyme IIs of Escherichia coli, enhanced phosphorylation is achieved with Bacillus subtilis HPr mutants, overview
additional information
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replacement of HPr and enzyme I of Escherichia coli with the homologous proteins from Bacillus subtilis, a gram-positive bacterium, leads to severe growth defects on PTS sugars, suggesting that HPr of Bacillus subtilis cannot efficiently phosphorylate the enzyme IIs of Escherichia coli, enhanced phosphorylation is achieved with Bacillus subtilis HPr mutants, overview
additional information
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fusion protein of enzyme plus the remaining three subunits of glucose phosphotransferase system and Ala-Pro-rich linker sequences
additional information
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overview on mutants
additional information
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enzyme deletion mutant, alternative pathways
additional information
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enzyme deletion mutants, virulence of
additional information
deletion mutant strains, e.g. strains LJ705 and SB2950, lacking enzyme I and HPr from the phosphoenolpyruvate:sugar phosphotransferase system produces the constitutive analogues enzyme I fructose and FPr, but does no grow in minimal medium supplemented with non-PTS sugars melibiose, glycerol, and maltose, in complete absence of Luria-Bertani broth, growth occurs after addition of AMP, metabolism and phenotypes, overview
additional information
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deletion mutant strains, e.g. strains LJ705 and SB2950, lacking enzyme I and HPr from the phosphoenolpyruvate:sugar phosphotransferase system produces the constitutive analogues enzyme I fructose and FPr, but does no grow in minimal medium supplemented with non-PTS sugars melibiose, glycerol, and maltose, in complete absence of Luria-Bertani broth, growth occurs after addition of AMP, metabolism and phenotypes, overview
