2.7.3.9: phosphoenolpyruvate-protein phosphotransferase

This is an abbreviated version!
For detailed information about phosphoenolpyruvate-protein phosphotransferase, go to the full flat file.

Word Map on EC 2.7.3.9

2.7.3.9

hpr

phosphocarrier

fructose

permease

streptococcus

catabolite

histidine-containing

typhimurium

mannitol

lactose

glucose-specific

non-pts

iiiglc

antiterminator

unphosphorylated

mutans

mannitol-specific

histidyl

cellobiose

2-deoxyglucose

alpha-glucoside

casei

salivarius

melibiose

energy-coupling

beta-glucoside

pep-dependent

fructose-specific

eiias

medicine

starch-branching

glucitol

drug development

nonmetabolizable

dikinase

transphosphorylation

carnosus

capricolum

hexitols

Reaction

Synonyms

EIC, EIN, enzyme I, enzyme I of the phosphotransferase system, More, non-sugar-specific phosphotransferase, PEP:sugar phosphotransferase system enzyme I, PEP:sugar PT, phosphoenolpyruvate protein phosphotransferase, phosphoenolpyruvate sugar phosphotransferase enzyme I, phosphoenolpyruvate-dependent phosphotransferase, phosphoenolpyruvate-dependent phosphotransferase system, phosphoenolpyruvate-dependent phosphotransferase system enzyme I, phosphoenolpyruvate-protein phosphotransferase, phosphoenolpyruvate:carbohydrate phosphotransferase system, phosphoenolpyruvate:glucose/mannose phosphotransferase system, phosphoenolpyruvate:glycose phosphotransferase system, phosphoenolpyruvate:glycose phosphotransferase system enzyme I, phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase, phosphoenolpyruvate:sugar phosphotransferase, phosphoenolpyruvate:sugar phosphotransferase system, phosphopyruvate-protein factor phosphotransferase, phosphopyruvate-protein phosphotransferase, phosphotransferase enzyme I, phosphotransferase system component enzyme I, phosphotransferase system enzyme I, phosphotransferase, phosphoenolpyruvate-protein, protein kinase enzyme I, PTS, ptsA, ptsI, sugar-PEP phosphotransferase enzyme I, YpqE

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.3 Phosphotransferases with a nitrogenous group as acceptor

2.7.3.9 phosphoenolpyruvate-protein phosphotransferase

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Results	in table
6	Activating Compound
39100	AA Sequence
9	Application
1	CAS Registry Number
25	Cloned(Commentary)
6	Crystallization (Commentary)
2	Expression
20	General Information
2	General Stability
34	Inhibitors
2	Ki Value [mM]
15	KM Value [mM]
20	Localization
14	Metals/Ions
30	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
96	Organism
39	PDB ID
12	pH Optimum
5	pH Range
4	pH Stability
8	Posttranslational Modification
34	Protein Variants
24	Purification (Commentary)
9	Reaction
8	Reaction Type
88	Reference
7	Specific Activity [micromol/min/mg]
10	Storage Stability
81	Substrates and Products (Substrate)
53	Subunits
104	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
5	Temperature Stability [°C]

Subunits

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Subunits on EC 2.7.3.9 - phosphoenolpyruvate-protein phosphotransferase

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dimer

homodimer

monomer

monomer or dimer

x * 63500, enzyme I, EI, the monomer undergoes a monomer/dimer transition and only the dimer form accepts the phosphoryl group from phosphoenolpyruvate. The crystal structure of EI, PDB ID 1ZYM, reveals a dimeric protein in which each subunit comprises three domains: a domain that binds the partner HPr, a domain that carries the phosphorylated histidine residue, and a PEP-binding domain

738469

tetramer

2 entries

additional information

Escherichia coli

enzyme I of the PEP:sugar phosphotransferase system is regulated by a monomer-dimer equilibrium. A Mg2+-dependent autophosphorylation by phosphoenolpyruvate requires the homodimer. Physiological concentrations of phosphoenolpyruvate and Mg2+ increase, whereas pyruvate and Mg2+ decrease the amount of dimeric, active dephospho-enzyme I

663326