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2.7.4.14: UMP/CMP kinase

This is an abbreviated version!
For detailed information about UMP/CMP kinase, go to the full flat file.

Word Map on EC 2.7.4.14

Reaction

ATP
+
UMP
=
ADP
+
UDP

Synonyms

ATP:UMP-CMP phosphotransferase, CMP kinase, CMP/UMP kinase, CMPK, CMPK1, CMPK2, CTP:CMP phosphotransferase, cytidine monophosphate kinase, cytidine/uridine monophosphate kinase 2, cytidylate kinase, dCK, deoxycytidine kinase, EC 2.7.4.5, kinase, cytidylate (phosphorylating), More, MssA protein, nucleoside monophosphate kinase, P25, pyrimidine nucleoside monophosphate kinase, UCK, UMP-CMP kinase, UMP-CMP kinase 2, UMP-CMPK2, UMP/CMP kinase, UMP/CMP kinase 1, UMP/CMPK1, UMPK, uridine monophosphate/cytidine monophosphate kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.4 Phosphotransferases with a phosphate group as acceptor
                2.7.4.14 UMP/CMP kinase

Disease

Disease on EC 2.7.4.14 - UMP/CMP kinase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
5'-nucleotidase deficiency
Pyrimidine nucleoside monophosphate kinase hyperactivity in hereditary erythrocyte pyrimidine 5'-nucleotidase deficiency.
Abortion, Missed
Pigment epithelium?derived factor facilitates NLRP3 inflammasome activation through downregulating cytidine monophosphate kinase 2: A potential treatment strategy for missed abortion.
Acquired Immunodeficiency Syndrome
Substrate-induced conformational changes in human UMP/CMP kinase.
Acute Lung Injury
MiR-494-3p alleviates acute lung injury through regulating NLRP3 activation by targeting CMPK2.
Atherosclerosis
Mitochondrial protein CMPK2 regulates IFN alpha-enhanced foam cell formation, potentially contributing to premature atherosclerosis in SLE.
Bacterial Infections
CMPK2 of triploid crucian carp is involved in immune defense against bacterial infection.
Breast Neoplasms
Potential role of CMPK1, SLC29A1, and TLE4 polymorphisms in gemcitabine-based chemotherapy in HER2-negative metastatic breast cancer patients: pharmacogenetic study results from the prospective randomized phase II study of eribulin plus gemcitabine versus paclitaxel plus gemcitabine (KCSG-BR-13-11).
Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients.
Carcinoma, Hepatocellular
Differences between pyrimidine nucleoside monophosphate kinase from rat Novikoff ascites hepatoma and rat liver.
Pyrimidine nucleoside monophosphate kinase from rat liver and rat Novikoff ascites hepatoma (EC 2.7.4.14).
Carcinoma, Non-Small-Cell Lung
Differential Effect of Polymorphisms of CMPK1 and RRM1 on Survival in Advanced Non-small Cell Lung Cancer Patients Treated with Gemcitabine or Taxane/Cisplatinum.
Carcinoma, Ovarian Epithelial
Cytidine monophosphate kinase is inhibited by the TGF-? signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer.
Data on the association of CMPK1 with clinicopathological features and biological effect in human epithelial ovarian cancer.
Colorectal Neoplasms
Long noncoding RNA CMPK2 promotes colorectal cancer progression by activating the FUBP3-c-Myc axis.
Hepatitis B, Chronic
MiR-3613-3p impairs IFN-induced immune response by targeting CMPK1 in chronic hepatitis B.
Infections
Genetic architecture of gene expression underlying variation in host response to porcine reproductive and respiratory syndrome virus infection.
Identification of enzymes catalyzing two-step phosphorylation of cidofovir and the effect of cytomegalovirus infection on their activities in host cells.
Identification of fish CMPK2 as an interferon stimulated gene against SVCV infection.
Mitochondrial CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways.
Influenza, Human
Impact of human rhinoviruses on gene expression in pediatric patients with severe acute respiratory infection.
Leukemia
Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria.
Lung Neoplasms
Comprehensive evaluation of the response of genes to the administration of the antitumor drug S-1 using a low density array.
Differential Effect of Polymorphisms of CMPK1 and RRM1 on Survival in Advanced Non-small Cell Lung Cancer Patients Treated with Gemcitabine or Taxane/Cisplatinum.
Multiple Sclerosis
Long-term genome-wide blood RNA expression profiles yield novel molecular response candidates for IFN-beta-1b treatment in relapsing remitting MS.
Myopia
Corneal curvature-associated MTOR variant differentiates mild myopia from high myopia in Han Chinese population.
Neoplasm Metastasis
Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients.
Neoplasms
Cytidine monophosphate kinase is inhibited by the TGF-? signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer.
Data on the association of CMPK1 with clinicopathological features and biological effect in human epithelial ovarian cancer.
Differences between pyrimidine nucleoside monophosphate kinase from rat Novikoff ascites hepatoma and rat liver.
Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria.
Long intracellular retention of 4'-thio-arabinofuranosylcytosine 5'-triphosphate as a critical factor for the anti-solid tumor activity of 4'-thio-arabinofuranosylcytosine.
Micropreparative immobilized pH gradient two-dimensional electrophoresis in combination with protein microsequencing for the analysis of human liver proteins.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria.
Staphylococcal Infections
A Novel Peptide Nucleic Acid against the Cytidine Monophosphate Kinase of S. aureus Inhibits Staphylococcal Infection In Vivo.
Stomach Neoplasms
CMPK1 Regulated by miR-130b Attenuates Response to 5-FU Treatment in Gastric Cancer.
Stroke
Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology.
Triple Negative Breast Neoplasms
Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients.
Tuberculosis
Insight from the structural molecular model of cytidylate kinase from Mycobacterium tuberculosis.
Kinetic mechanism and energetics of binding of phosphoryl group acceptors to Mycobacterium tuberculosis cytidine monophosphate kinase.
Molecular modeling and dynamics studies of cytidylate kinase from Mycobacterium tuberculosis H37Rv.
Mycobacterium Cytidylate Kinase Appears to Be an Undruggable Target.
The Rv1712 Locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP.
ump/cmp kinase deficiency
Mitochondrial CMPK2 mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways.
Viremia
Genetic architecture of gene expression underlying variation in host response to porcine reproductive and respiratory syndrome virus infection.