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2.7.4.14: UMP/CMP kinase

This is an abbreviated version!
For detailed information about UMP/CMP kinase, go to the full flat file.

Word Map on EC 2.7.4.14

Reaction

ATP
+
UMP
=
ADP
+
UDP

Synonyms

ATP:UMP-CMP phosphotransferase, CMP kinase, CMP/UMP kinase, CMPK, CMPK1, CMPK2, CTP:CMP phosphotransferase, cytidine monophosphate kinase, cytidine/uridine monophosphate kinase 2, cytidylate kinase, dCK, deoxycytidine kinase, EC 2.7.4.5, kinase, cytidylate (phosphorylating), More, MssA protein, nucleoside monophosphate kinase, P25, pyrimidine nucleoside monophosphate kinase, UCK, UMP-CMP kinase, UMP-CMP kinase 2, UMP-CMPK2, UMP/CMP kinase, UMP/CMP kinase 1, UMP/CMPK1, UMPK, uridine monophosphate/cytidine monophosphate kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.4 Phosphotransferases with a phosphate group as acceptor
                2.7.4.14 UMP/CMP kinase

Inhibitors

Inhibitors on EC 2.7.4.14 - UMP/CMP kinase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5-Br-uracil vinylphosphonate
-
5-Cl-uracil vinylphosphonate
-
5-F-Phe-uracil vinylphosphonate
-
5-Phe-S-uracil vinylphosphonate
-
5-Phe-uracil vinylphosphonate
-
CTP
-
inhibits reaction with ATP and UMP, CMP or dCMP
CuSO4
-
0.25 mM, 96% inhibition of enzyme form UMPK1 and 92% inhibition of enzyme form UMPK2
dCMP
-
competitive inhibition of UMP phosphorylation
dCTP
-
inhibits reaction with ATP and UMP, CMP or dCMP
DTNB
-
0.009 mM, 50% inhibition
F-
-
complete inhibition at 25 mM
HgCl2
iodoacetamide
-
-
iodoacetate
-
0.05 mM, 50% inhibition
L-CMP
excess of L-CMP
lead nitrate
-
0.25 mM, 52% inhibition of enzyme form UMPK1 and 40% inhibition of enzyme form UMPK2
MgATP2-
-
competitive with UMP
NaClO
-
250 mM
NaSCN
-
250 mM
p-hydroxymercuribenzoate
-
0.02 mM, 50% inhibition
p-Hydroxymercuriphenyl sulfonate
-
0.02 mM, 50% inhibition
P1,P5-di(adenosine-5')pentaphosphate
-
PCMB
-
0.1 mM, 69% loss of activity
TTP
-
inhibits reaction with ATP and UMP, CMP or dCMP
UDP
-
product inhibition
UMP
-
substrate inhibition above 0.2 mM
uracil vinylphosphonate
-
UTP
-
inhibits reaction with ATP and UMP, CMP or dCMP
ZnCl2
-
0.25 mM, 55% inhibition of enzyme form UMPK1 and 30% inhibition of enzyme form UMPK2
additional information
-