Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.7.4.14: UMP/CMP kinase

This is an abbreviated version!
For detailed information about UMP/CMP kinase, go to the full flat file.

Word Map on EC 2.7.4.14

Reaction

ATP
+
UMP
=
ADP
 +
UDP

Synonyms

ATP:UMP-CMP phosphotransferase, CMP kinase, CMP/UMP kinase, CMPK, CMPK1, CMPK2, CTP:CMP phosphotransferase, cytidine monophosphate kinase, cytidine/uridine monophosphate kinase 2, cytidylate kinase, dCK, deoxycytidine kinase, EC 2.7.4.5, kinase, cytidylate (phosphorylating), More, MssA protein, nucleoside monophosphate kinase, P25, pyrimidine nucleoside monophosphate kinase, UCK, UMP-CMP kinase, UMP-CMP kinase 2, UMP-CMPK2, UMP/CMP kinase, UMP/CMP kinase 1, UMP/CMPK1, UMPK, uridine monophosphate/cytidine monophosphate kinase

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.4 Phosphotransferases with a phosphate group as acceptor
                2.7.4.14 UMP/CMP kinase

KM Value

KM Value on EC 2.7.4.14 - UMP/CMP kinase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.45
2',2'-difluorodeoxycytidine
pH 8.0, 37°C
0.36
2'-azido-D-dCMP
-
pH 7.4, 37°C
0.9
2'-azido-D-dUMP
-
pH 7.4, 37°C
1.2
2'-azido-L-dCMP
-
pH 7.4, 37°C
1.3
2'-azido-L-dUMP
-
pH 7.4, 37°C
2.08
5-aza-cidofovir
pH and temperature not specified in the publication, recombinant wild-type enzyme
0.26 - 0.917
ara-CMP
1.4
araCMP
pH 8.0, 37°C
0.029 - 0.68
ATP
0.272 - 1.037
beta-D-2',3'-dideoxy-CMP
0.36
beta-D-2'-azido-2'-dCMP
-
0.9
beta-D-2'-azido-2'-dUMP
-
0.228
beta-L-(-)-2',3'-dideoxy-2',3'-didehydro-5-fluoro-CMP
-
37°C
0.15 - 2
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate
0.697
beta-L-2',3'-dideoxy-CMP
-
37°C
1.2
beta-L-2'-azido-2'-dCMP
-
1.3
beta-L-2'-azido-2'-dUMP
-
2
cCMP
-
pH 7.4, 37°C
1 - 2.3
Cidofovir
0.0053 - 3.09
CMP
0.315 - 0.327
cytarabine
0.02
D-CMP
1
D-dCMP
1.3
D-dUMP
0.05
D-UMP
0.074 - 0.61
dATP
0.017 - 2.77
dCMP
0.82
dCTP
-
reaction with CMP, liver enzyme
0.1 - 8.5
dUMP
0.0146
gemcitabine
wild-type DCK
0.581
gemcitabine monophosphate
-
37°C
0.246
gemcitabine phosphate
wild-type CMPK
0.494
L-(-)-2',3'-dideoxy-3'-thia-CMP
-
37°C
0.25
L-(-)-2',3'-dideoxy-5-fluoro-3'-thia-CMP
-
37°C, His-tagged UMP/CMP kinase
0.15
L-3TCMP
-
0.75
L-CMP
0.73
L-dCMP
0.7
L-dUMP
0.02 - 6.3
UMP
additional information
additional information
Km values of mutant enzymes, overview
-