2.7.4.2: phosphomevalonate kinase
This is an abbreviated version!
For detailed information about phosphomevalonate kinase, go to the full flat file.
Word Map on EC 2.7.4.2
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2.7.4.2
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isopentenyl
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isoprenoids
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diphosphomevalonate
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5-diphosphate
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mevalonate-5-pyrophosphate
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pyrophosphomevalonate
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2.7.1.36
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cholesterogenesis
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zellweger
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nonsterol
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medicine
- 2.7.4.2
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isopentenyl
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isoprenoids
- diphosphomevalonate
- 5-diphosphate
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mevalonate-5-pyrophosphate
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pyrophosphomevalonate
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2.7.1.36
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cholesterogenesis
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zellweger
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nonsterol
- medicine
Reaction
Synonyms
5-phosphomevalonate kinase, ATP:5-phosphomevalonate phosphotransferase, CcPMK, ERG8, GbPMK, kinase, phosphomevalonate (phosphorylating), mevalonate phosphate kinase, mevalonate-5-phosphate kinase, mevalonic acid phosphate kinase, More, phosphomevalonate kinase, phosphomevalonic kinase, PMK, PMVAK, PMVK, SSO2988
ECTree
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Substrates Products
Substrates Products on EC 2.7.4.2 - phosphomevalonate kinase
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REACTION DIAGRAM
ADPbetaS + 5-diphosphomevalonate
ATPbetaS + 5-phosphomevalonate
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41fold slower kcat than with ADP
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r
ITP + 5-phosphomevalonate
IDP + 5-diphosphomevalonate
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6% of activity with ATP
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?
UTP + 5-phosphomevalonate
UDP + 5-diphosphomevalonate
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13% of activity with ATP
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?
ADP + (R)-5-diphosphomevalonate
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-
-
?
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
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-
-
?
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
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-
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r
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
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mevalonate pathway of isopentenyl diphosphate biosynthesis
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-
?
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
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mevalonate pathway of isopentenyl diphosphate biosynthesis
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-
?
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
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-
-
?
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
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-
-
?
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
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mevalonate pathway of isopentenyl diphosphate biosynthesis
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-
?
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
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PMK catalyzes the transfer of the gamma-phosphoryl group of ATP to (R)-5-phosphomevalonate, which results in the formation of ADP and (R)-5-diphosphomevalonate
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-
?
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
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-
-
?
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
the enzyme is involved in the classical mevalonate pathway
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-
?
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
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-
-
?
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
the enzyme is involved in the classical mevalonate pathway
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-
?
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
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-
-
?
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
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-
-
?
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
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-
-
-
?
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
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-
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ir
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
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active site structure and substrate binding coformation, detailed overview. Ligand binding reverses the side-chain orientations of two antiparallel lysines residues 100 and 101 with the result that Lys101 is switched into a position in which its ammonium ion is in direct contact with the beta,gamma-bridging atom of the nucleotide, where it is expected to stabilize both the ground and transition states of the reaction. The active site of PMK seems spacious enough to accommodate interconversion of the reactive and nonreactive conformers. A substantial fraction of the PMK active site is occupied by an active site water pentamer, which clusters near the charged regions of the substrate
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ir
ATP + (R)-5-phosphomevalonate
ADP + (R)-5-diphosphomevalonate
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one of the initial steps in the biosynthesis of steroids and isoprenoids
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-
r
ADP + 5-diphosphomevalonate
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involved in isoprenoid biosynthesis pathway
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?
ATP + (R)-5-phosphomevalonate
ADP + 5-diphosphomevalonate
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-
-
?
ATP + (R)-5-phosphomevalonate
ADP + 5-diphosphomevalonate
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enzyme of mevalonate pathway
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r
ATP + (R)-5-phosphomevalonate
ADP + 5-diphosphomevalonate
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one of the enzymes in the biosynthetic pathway of the polyisoprenoid precursor isopentenyl diphosphate, enzyme has no regulatory function in cholesterol biosynthesis in liver
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r
ADP + (R)-mevalonate 5-diphosphate
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-
-
?
ATP + (R)-mevalonate 5-phosphate
ADP + (R)-mevalonate 5-diphosphate
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-
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r
ATP + (R)-mevalonate 5-phosphate
ADP + (R)-mevalonate 5-diphosphate
the enzyme catalyzes a key step in isoprenoid/sterol biosynthesis
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-
r
ADP + (R,S)-5-diphosphomevalonate
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-
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?
ATP + (R,S)-5-phosphomevalonate
ADP + (R,S)-5-diphosphomevalonate
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-
-
-
?
ATP + 5-phosphomevalonate
ADP + 5-diphosphomevalonate
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no activity with CTP and GTP
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?
ATP + 5-phosphomevalonate
ADP + 5-diphosphomevalonate
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maximal activity at 10 mM ATP
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?
ATP + 5-phosphomevalonate
ADP + 5-diphosphomevalonate
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-
-
?
ATP + 5-phosphomevalonate
ADP + 5-diphosphomevalonate
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-
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r
ATP + 5-phosphomevalonate
ADP + 5-diphosphomevalonate
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(3R)-phosphomevalonate
(3R)-diphosphomevalonate
r
ATP + 5-phosphomevalonate
ADP + 5-diphosphomevalonate
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absolute specificity for ATP
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?
ATP + 5-phosphomevalonate
ADP + 5-diphosphomevalonate
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absolute specificity for ATP
(3R)-diphosphomevalonate
r
ATP + 5-phosphomevalonate
ADP + 5-diphosphomevalonate
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the equilibrium constant is near unity at pH 7.5 and 30°C
(3R)-diphosphomevalonate
r
CDP + (R,S)-5-diphosphomevalonate
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0.4% activity
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-
?
CTP + (R,S)-5-phosphomevalonate
CDP + (R,S)-5-diphosphomevalonate
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0.4% activity
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-
?
GDP + (R,S)-5-diphosphomevalonate
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3.6% activity
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-
?
GTP + (R,S)-5-phosphomevalonate
GDP + (R,S)-5-diphosphomevalonate
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3.6% activity
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-
?
TDP + (R,S)-5-diphosphomevalonate
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1.6% activity
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-
?
TTP + (R,S)-5-phosphomevalonate
TDP + (R,S)-5-diphosphomevalonate
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1.6% activity
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-
?
?
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binding structure of AMPPNP, that interactswith both stationary and mobile regions of the PMK scaffold. The stationary region includes Ile65 and Leu66 as well as the glycine/serine-rich region, F102GLGSSGLV110, of motif II
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?
additional information
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the recombinant enzyme phosphorylates racemic vinyl, ethyl, n-propyl, n-butyl, i-butyl, 2-propenyl, allyl, ethynyl, and 1-propynyl mevalonate lactone analogues, that are phosphorylated by mevalonate kinase, EC 2.7.1.36, in a first step, overview
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?