2.7.4.21: inositol-hexakisphosphate 5-kinase

This is an abbreviated version!
For detailed information about inositol-hexakisphosphate 5-kinase, go to the full flat file.

Reaction

Synonyms

AtIPK2alpha, AtIpk2beta, ATP:1D-myo-inositol-hexakisphosphate phosphotransferase, AtVip1, AtVip2, diphosphoinositol pentakisphosphate kinase 2, diphosphoinositol pentakisphosphate synthetase, EC 2.7.1.152, EhIP6KA, IHPK2, inositol hexakisphosphate 5-kinase, inositol hexakisphosphate kinase, inositol hexakisphosphate kinase 1, inositol hexakisphosphate kinase 2, inositol hexakisphosphate kinase 3, inositol hexakisphosphate kinase type 2, inositol hexakisphosphate kinase-1, inositol hexakisphosphate kinase-2, inositol hexakisphosphate kinase-3, inositol polyphosphate kinase, inositol-hexakisphosphate kinase, InsP6 kinase, InsP6-kinase, InsP6K1, InsP6K2, InsP6K3, IP6 kinase, IP6 kinase 1, IP6K, IP6K1, IP6K2, IP6K3, Ipk2, IPMK, Kcs1, kinase (phosphorylating), inositol hexakisphosphate, More, Pi uptake stimulator, PiUS, PPIP5K1, PPIP5K2, RID-2

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.4 Phosphotransferases with a phosphate group as acceptor

                2.7.4.21 inositol-hexakisphosphate 5-kinase

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Results	in table
16	Activating Compound
20	AA Sequence
3	Application
1	CAS Registry Number
31	Cloned(Commentary)
10	Cofactor
3	Crystallization (Commentary)
179	Disease/ Diagnostics
3	Expression
97	General Information
15	IC50 Value
33	Inhibitors
2	kcat/KM [mM/s]
11	KM Value [mM]
31	Localization
10	Metals/Ions
8	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
102	Organism
1	Pathway
17	PDB ID
5	pH Optimum
1	Posttranslational Modification
36	Protein Variants
7	Purification (Commentary)
2	Reaction
4	Reaction Type
70	Reference
1	Renatured (Commentary)
104	Source Tissue
2	Specific Activity [micromol/min/mg]
2	Storage Stability
63	Substrates and Products (Substrate)
13	Subunits
148	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Turnover Number [1/s]

KM Value

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KM Value on EC 2.7.4.21 - inositol-hexakisphosphate 5-kinase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00039

1D-myo-inositol hexakisphosphate

Homo sapiens

O43314

isoform PPIP5K2, in 20 mM HEPES-NaOH pH 7.2, 50 m MKCl, at 37°C

721882

0.00197

5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate

Rattus norvegicus

-

pH 6.8, 37°C

642551

1.57

ADP

Rattus norvegicus

-

pH 6.8, 37°C

642551

0.037 - 1.4

ATP

4 entries

0.0055

D-myo-inositol-1,3,4,5,6-pentakisphosphate

Homo sapiens

Q96PC2

pH 7.0, 37°C

642554

0.0007 - 0.0061

Inositol hexakisphosphate

3 entries

0.037

ATP

Homo sapiens

O43314

isoform PPIP5K2, using 1D-myo-inositol hexakisphosphate as cosubstrate, in 20 mM HEPES-NaOH pH 7.2, 50 mM KCl, at 37°C

721882

0.382

ATP

Homo sapiens

Q92551

pH 6.95, 37°C

762234

1.35

ATP

Rattus norvegicus

-

pH 6.8, 37°C

642551

1.4

ATP

Rattus norvegicus

-

pH and temperature not specified in the publication

721249

0.0007

Inositol hexakisphosphate

Rattus norvegicus

-

pH 6.8, 37°C

642551

0.0009

Inositol hexakisphosphate

Homo sapiens

Q96PC2

pH 7.0, 37°C

642554

0.0061

Inositol hexakisphosphate

Xenopus sp.

-

-

661721