2.7.4.22: UMP kinase

This is an abbreviated version!
For detailed information about UMP kinase, go to the full flat file.

Reaction

Synonyms

ATP:UMP phosphotransferase, HP0777 protein, More, pyrH, Rv2883c, SsUMPK, UMP kinase, UMP-kinase, UMPK, UMPKs, uridine monophosphate kinase, uridylate kinase, XC1936

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.4.22 UMP kinase

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Results	in table
72	Activating Compound
42057	AA Sequence
14	Application
1	CAS Registry Number
38	Cloned(Commentary)
7	Cofactor
15	Crystallization (Commentary)
10	General Information
25	IC50 Value
103	Inhibitors
4	kcat/KM [mM/s]
26	Ki Value [mM]
186	KM Value [mM]
5	Localization
28	Metals/Ions
30	Molecular Weight [Da]
31	Natural Substrates/ Products (Substrates)
68	Organism
5	Pathway
92	PDB ID
14	pH Optimum
4	pH Range
2	pH Stability
1	pI Value
72	Protein Variants
36	Purification (Commentary)
2	Reaction
4	Reaction Type
50	Reference
1	Renatured (Commentary)
135	Specific Activity [micromol/min/mg]
7	Storage Stability
83	Substrates and Products (Substrate)
38	Subunits
125	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
28	Temperature Stability [°C]
7	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.7.4.22 - UMP kinase

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4.6

1-[2-[(2-amino-6-phenylpyrimidin-4-yl)amino]phenyl]ethanone

Staphylococcus aureus

pH 7.5, 22°C

737591

139

2-amino-8-(2-oxo-2-phenylethoxy)-1,4,5,9-tetrahydro-6H-purin-6-one

Staphylococcus aureus

pH 8.5, 23°C

737591

243

2-amino-8-[2-(2-methylphenyl)-2-oxoethoxy]-1,4,5,9-tetrahydro-6H-purin-6-one

Staphylococcus aureus

pH 8.5, 23°C

737591

2-amino-8-[2-(3-methylphenyl)-2-oxoethoxy]-1,4,5,9-tetrahydro-6H-purin-6-one

Staphylococcus aureus

pH 8.5, 23°C

737591

2-amino-8-[2-(4-fluorophenyl)-2-oxoethoxy]-1,4,5,9-tetrahydro-6H-purin-6-one

Staphylococcus aureus

pH 8.5, 23°C

737591

2-amino-8-[2-(4-hydroxyphenyl)-2-oxoethoxy]-1,4,5,9-tetrahydro-6H-purin-6-one

Staphylococcus aureus

pH 8.5, 23°C

737591

2-amino-8-[2-(4-methoxyphenyl)-2-oxoethoxy]-1,4,5,9-tetrahydro-6H-purin-6-one

Staphylococcus aureus

pH 8.5, 23°C

737591

2-amino-8-[2-(4-methylphenyl)-2-oxoethoxy]-1,4,5,9-tetrahydro-6H-purin-6-one

Staphylococcus aureus

pH 8.5, 23°C

737591

254

4-[(2-amino-6-oxo-4,5,6,9-tetrahydro-1H-purin-8-yl)methyl]benzonitrile

Staphylococcus aureus

pH 8.5, 23°C

737591

4-[[(2-amino-6-oxo-4,5,6,9-tetrahydro-1H-purin-8-yl)oxy]acetyl]benzonitrile

Staphylococcus aureus

pH 8.5, 23°C

737591

0.02

5-iodo-UTP

Mycobacterium tuberculosis

P9WHK5

wild type enzyme, at pH 7.4 and 30°C

723289

0.4

dTTP

Mycobacterium tuberculosis

P9WHK5

wild type enzyme, at pH 7.4 and 30°C

723289

0.24

dUTP

Mycobacterium tuberculosis

P9WHK5

wild type enzyme, at pH 7.4 and 30°C

723289

0.0156

N4,6-diphenylpyrimidine-2,4-diamine

Staphylococcus aureus

pH 7.5, 22°C

737591

32.9

N4-(2-methoxyphenyl)-6-phenylpyrimidine-2,4-diamine

Staphylococcus aureus

pH 7.5, 22°C

737591

53.8

N4-(2-methylphenyl)-6-phenylpyrimidine-2,4-diamine

Staphylococcus aureus

pH 7.5, 22°C

737591

0.1

N4-(3-methylphenyl)-6-phenylpyrimidine-2,4-diamine

Staphylococcus aureus

above, pH 7.5, 22°C

737591

0.1

N4-(4-methoxyphenyl)-6-phenylpyrimidine-2,4-diamine

Staphylococcus aureus

above, pH 7.5, 22°C

737591

0.1

N4-(4-methylphenyl)-6-phenylpyrimidine-2,4-diamine

Staphylococcus aureus

above, pH 7.5, 22°C

737591

0.025

N4-ethyl-N4,6-diphenylpyrimidine-2,4-diamine

Staphylococcus aureus

pH 7.5, 22°C

737591

phosphate

Ureaplasma parvum

Q9PPX6

phosphate ion is found in the active site

692284

0.01 - 0.45

UTP

4 entries