2.7.4.22: UMP kinase
This is an abbreviated version!
For detailed information about UMP kinase, go to the full flat file.
Reaction
Synonyms
ATP:UMP phosphotransferase, HP0777 protein, More, pyrH, Rv2883c, SsUMPK, UMP kinase, UMP-kinase, UMPK, UMPKs, uridine monophosphate kinase, uridylate kinase, XC1936
ECTree
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Substrates Products
Substrates Products on EC 2.7.4.22 - UMP kinase
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REACTION DIAGRAM
ATP + dUMP
ADP + dUDP
3.7% of the activity detected with UMP
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ATP + UMP
ADP + UDP
Q81S73
an essential metabolic step with a structure-based mechanism for the allosteric behavior of bacterial enzyme, overview
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ATP + UMP
ADP + UDP
Q81S73
an essential metabolic step with a structure-based mechanism for the allosteric behavior of bacterial enzyme, overview
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ATP + UMP
ADP + UDP
at 30°C, pH 7.4, in the presence of 2 mM MgCl2
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ATP + UMP
ADP + UDP
the enzyme regulatory mechanisms involve GTP and UTP, overview
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ATP + UMP
ADP + UDP
movements induced by binding uridine nucleotides, GTP and UTP interaction mechanism, analysis, overview
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ATP + UMP
ADP + UDP
low activity with dUMP as substrate, no activity with CMP, dTMP, AMP, IMP, XMP, GMP, low activity with dATP, GTP, CTP and UTP as substrate
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ATP + UMP
ADP + UDP
high substrate specificity toward UMP and ATP
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ATP + UMP
ADP + UDP
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ATP + UMP
ADP + UDP
30°C, pH 7.4
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ATP + UMP
ADP + UDP
37°C, pH 7.8, 7.5 mM MgCl2
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ATP + UMP
ADP + UDP
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ATP + UMP
ADP + UDP
37°C, pH 7.8, 7.5 mM MgCl2
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ATP + UMP
ADP + UDP
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ATP + UMP
ADP + UDP
37°C, pH 7.8, 7.5 mM MgCl2
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ATP + UMP
ADP + UDP
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ATP + UMP
ADP + UDP
37°C, pH 7.8, 7.5 mM MgCl2
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ATP + UMP
ADP + UDP
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ATP + UMP
ADP + UDP
37°C, pH 7.8, 7.5 mM MgCl2
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ATP + UMP
ADP + UDP
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ATP + UMP
ADP + UDP
37°C, pH 7.8, 7.5 mM MgCl2
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ATP + UMP
ADP + UDP
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UMP kinase catalyzes the transfer of the gamma-phosphate of ATP to UMP
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ATP + UMP
ADP + UDP
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UMP kinase catalyzes the transfer of the gamma-phosphate of ATP to UMP
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ATP + UMP
ADP + UDP
at 37°C, pH 7.5, in the presence of MnCl2 or MgCl2
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no reaction with dUMP, CMP, dCMP or TMP as substrate
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additional information
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no reaction with dUMP, CMP, dCMP or TMP as substrate
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additional information
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Asp93 appears as one of the key amino acids in the transfer of information from the regulatory site to the active site
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additional information
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Asp93 appears as one of the key amino acids in the transfer of information from the regulatory site to the active site
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additional information
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no activity with CMP, dTMP, or the purine nucleotides (AMP, IMP, XMP, and GMP), ATP is by far the most effective phosphoryl donor, although a very weak activity (less than 1% of ATP activity) is seen with dATP, GTP, CTP, and UTP
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additional information
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no activity with CMP, dTMP, or the purine nucleotides (AMP, IMP, XMP, and GMP), ATP is by far the most effective phosphoryl donor, although a very weak activity (less than 1% of ATP activity) is seen with dATP, GTP, CTP, and UTP
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additional information
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UMP kinase exhibits an intrinsic fluorescence, due to its unique tryptophan, decreasing with the increase of UTP concentration
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additional information
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enzyme activity detection by the coupled pyruvate kinase/lactate dehydrogenase assay, UMP kinase assay development and optimization, overview
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additional information
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enzyme activity detection by the coupled pyruvate kinase/lactate dehydrogenase assay, UMP kinase assay development and optimization, overview
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additional information
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bacterial UMP kinases are crucial enzymes that are responsible for microbial UTP biosynthesis, and bacterial UMPKs are specific for the phosphorylation of UMP only showing no dual activity in contrast to eukaryotic enzymes
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additional information
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the enzyme possesses well defined loop regions involved in substrate-analogue binding, overview
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