2.7.4.24: diphosphoinositol-pentakisphosphate 1-kinase

This is an abbreviated version!
For detailed information about diphosphoinositol-pentakisphosphate 1-kinase, go to the full flat file.

Word Map on EC 2.7.4.24

2.7.4.24

pyrophosphate

polyphosphate

pp-insps

hexakisphosphate

5-insp7

tetrakisphosphate

bisdiphosphoinositol

spx

medicine

Reaction

1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate

1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate

Synonyms

ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase, diphospho-myo-inositol pentakisphosphate 5-kinase, diphosphoinositol pentakisphosphate kinase, diphosphoinositol pentakisphosphate kinase 2, diphosphoinositol-pentakisphosphate 1/3-kinase, diphosphoinositol-pentakisphosphate kinase, EC 2.7.1.155, IP7 kinase, kinase (phosphorylating), diphosphoinositol 1,2,3,4,5-pentakisphosphate 5-, More, PP-InsP5 kinase, PP-IP5 kinase, PPIP5K, PPIP5K1, PPIP5K2, VIP, VIP1, VIP2

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.4.24 diphosphoinositol-pentakisphosphate 1-kinase

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Results	in table
16	Activating Compound
9099	AA Sequence
2	Application
1	CAS Registry Number
9	Cloned(Commentary)
7	Cofactor
3	Crystallization (Commentary)
4	Disease/ Diagnostics
8	General Information
9	IC50 Value
20	Inhibitors
6	kcat/KM [mM/s]
12	KM Value [mM]
1	Localization
4	Metals/Ions
7	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
20	Organism
1	Pathway
20	PDB ID
7	pH Optimum
1	pH Range
16	Protein Variants
7	Purification (Commentary)
2	Reaction
1	Reaction Type
20	Reference
12	Source Tissue
1	Specific Activity [micromol/min/mg]
3	Storage Stability
35	Substrates and Products (Substrate)
4	Subunits
54	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 2.7.4.24 - diphosphoinositol-pentakisphosphate 1-kinase

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2,5-O-benzyl-myo-inositol 1,3,4,6-tetrakisphosphate

Homo sapiens

O43314

activates the ATP hydrolysis activity and inhibits the InsP6 kinase activity of the enzyme

738042

2-O-aminoethyl-myo-inositol 1,2,3,4,6-pentakisphosphate

Homo sapiens

O43314

738042

2-O-benzoyl-myo-inositol 1,2,3,4,6-pentakisphosphate

Homo sapiens

O43314

738042

2-O-benzyl-5-O-alpha-phosphonoacetyl-myo-inositol 1,3,4,6-tetrakisphosphate

Homo sapiens

O43314

stimulates ATP hydrolysis 9fold

738042

2-O-benzyl-5-O-diphosphate-myo-inositol 1,3,4,6-tetrakisphosphate

Homo sapiens

O43314

738042

2-O-benzyl-myo-inositol 1,2,3,4,6-pentakisphosphate

Homo sapiens

O43314

738042

2-O-butanoyl-myo-inositol 1,2,3,4,6-pentakisphosphate

Homo sapiens

O43314

738042

5-O-alpha-diphosphate-myo-inositol 1,3,4,6-tetrakisphosphate

Homo sapiens

O43314

738042

5-O-alpha-phoshonoacetyl-myo-inositol 1,3,4,6-tetrakisphosphate

Homo sapiens

O43314

738042

5-O-alpha-phosphonoacetyl-myo-inositol 1,2,3,4,6-pentakisphosphate

Homo sapiens

O43314

stimulates ATP hydrolysis 5fold

738042

monoperoxo(picolinato)oxovanadate(V)

15fold activation

PtdIns(4,5)P2

increases net 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate kinase activity 5fold

760744

sorbitol

Mesocricetus auratus

rapid activation in vivo

662914

sucrose

Mesocricetus auratus

rapid activation in vivo

662914

additional information

3 entries