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2.7.4.24: diphosphoinositol-pentakisphosphate 1-kinase

This is an abbreviated version!
For detailed information about diphosphoinositol-pentakisphosphate 1-kinase, go to the full flat file.

Word Map on EC 2.7.4.24

Reaction

ATP
+
1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
=
ADP
 +
1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate

Synonyms

ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase, diphospho-myo-inositol pentakisphosphate 5-kinase, diphosphoinositol pentakisphosphate kinase, diphosphoinositol pentakisphosphate kinase 2, diphosphoinositol-pentakisphosphate 1/3-kinase, diphosphoinositol-pentakisphosphate kinase, EC 2.7.1.155, IP7 kinase, kinase (phosphorylating), diphosphoinositol 1,2,3,4,5-pentakisphosphate 5-, More, PP-InsP5 kinase, PP-IP5 kinase, PPIP5K, PPIP5K1, PPIP5K2, VIP, VIP1, VIP2

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.4 Phosphotransferases with a phosphate group as acceptor
                2.7.4.24 diphosphoinositol-pentakisphosphate 1-kinase

Inhibitors

Inhibitors on EC 2.7.4.24 - diphosphoinositol-pentakisphosphate 1-kinase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2,5-O-benzyl-myo-inositol 1,3,4,6-tetrakisphosphate
activates the ATP hydrolysis activity and inhibits the PPIP5K2 activity and InsP6 kinase activity, and the 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme. The compound can inhibit inositol phosphate kinase activity without occupying the catalytic site
2-O-benzyl-5-(phosphonoacetic acid ester)-1D-myo-inositol tetrakisphosphate
-
2-O-benzyl-5-O-alpha-phosphonoacetyl-myo-inositol 1,3,4,6-tetrakisphosphate
stimulates ATP hydrolysis 9fold, but inhibits 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme. The compound can inhibit inositol phosphate kinase activity without occupying the catalytic site
2-O-benzyl-5-O-diphosphate-myo-inositol 1,3,4,6-tetrakisphosphate
activates ATP hydrolysis activity but inhibits 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme
2-O-benzyl-myo-inositol 1,2,3,4,6-pentakisphosphate
activates ATP hydrolysis activity but inhibits 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme
5-(phosphonoacetic acid ester)-1D-myo-inositol pentakisphosphate
most potent inhibitor
5-(phosphonoacetic acid ester)-1D-myo-inositol tetrakisphosphate
-
5-O-alpha-diphosphate-myo-inositol 1,3,4,6-tetrakisphosphate
activates ATP hydrolysis activity but inhibits 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme
5-O-alpha-phosphonoacetyl-myo-inositol 1,2,3,4,6-pentakisphosphate
stimulates ATP hydrolysis 5fold, but inhibits 1,5-[PP]2-InsP4 dephosphorylation activity of the enzyme
C8-PtdIns(4,5)P2
0.05 mM, inhibits 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate dephosphorylation by approximately 60%
-
chlorpromazine
-
inhibition in vivo
F-
-
50% inhibition at 0.03 mM
genistein
-
rapid inhibition in vivo
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide
-
i.e. W-7, rapid inhibition in vivo
phosphate
1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate phosphatase activities of PPIP5Ks are 40-90% inhibited by phosphate within the 0-1 mM range; 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate phosphatase activities of PPIP5Ks are 40-90% inhibited by phosphate within the 0-1 mM range
UNC10112646
directly inhibits PPIP5K-catalyzed phosphorylation of 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate to 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
UNC10225498
directly inhibits PPIP5K-catalyzed phosphorylation of 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate to 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
-
additional information
-