2.7.4.24: diphosphoinositol-pentakisphosphate 1-kinase

This is an abbreviated version!
For detailed information about diphosphoinositol-pentakisphosphate 1-kinase, go to the full flat file.

Reaction

Synonyms

ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase, diphospho-myo-inositol pentakisphosphate 5-kinase, diphosphoinositol pentakisphosphate kinase, diphosphoinositol pentakisphosphate kinase 2, diphosphoinositol-pentakisphosphate 1/3-kinase, diphosphoinositol-pentakisphosphate kinase, EC 2.7.1.155, IP7 kinase, kinase (phosphorylating), diphosphoinositol 1,2,3,4,5-pentakisphosphate 5-, More, PP-InsP5 kinase, PP-IP5 kinase, PPIP5K, PPIP5K1, PPIP5K2, VIP, VIP1, VIP2

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.4 Phosphotransferases with a phosphate group as acceptor

                2.7.4.24 diphosphoinositol-pentakisphosphate 1-kinase

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Results	in table
16	Activating Compound
9099	AA Sequence
2	Application
1	CAS Registry Number
9	Cloned(Commentary)
7	Cofactor
3	Crystallization (Commentary)
4	Disease/ Diagnostics
8	General Information
9	IC50 Value
20	Inhibitors
6	kcat/KM [mM/s]
12	KM Value [mM]
1	Localization
4	Metals/Ions
7	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
20	Organism
1	Pathway
20	PDB ID
7	pH Optimum
1	pH Range
16	Protein Variants
7	Purification (Commentary)
2	Reaction
1	Reaction Type
20	Reference
12	Source Tissue
1	Specific Activity [micromol/min/mg]
3	Storage Stability
35	Substrates and Products (Substrate)
4	Subunits
54	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
5	Turnover Number [1/s]

Substrates Products

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of the Enzyme Summary Page.

Substrates Products on EC 2.7.4.24 - diphosphoinositol-pentakisphosphate 1-kinase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP

1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP

2 entries

3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + ATP

3,5-bisdiphospho-1D-myo-inositol 1,2,4,6-tetrakisphosphate + ADP

2 entries

5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP

3,5-bisdiphospho-1D-myo-inositol 1,2,4,6-tetrakisphosphate + ADP

2 entries

ADP + 1,5-bis-diphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate

ATP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate

Homo sapiens

O43314

-

721882

-

-

r

ADP + 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate

ATP + 1D-myo-inositol hexakisphosphate

Homo sapiens

O43314

-

721882

-

-

r

ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate

ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate

3 entries

ADP + diphosphoinositol pentakisphosphate

ATP + ?

Rattus norvegicus

-

enzyme has ATP synthase activity

645048

-

-

?

ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate

ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate

3 entries

ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate

ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate

5 entries

ATP + 1D-myo-inositol hexakisphosphate

ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate

Homo sapiens

O43314

-

738042

-

-

?

ATP + 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate

ADP + 1,5-bis-diphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate

Homo sapiens

O43314

-

721882

-

-

r

ATP + 5-diphospho-1D-myo-inositol pentakisphosphate

ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate

2 entries

ATP + 5-diphospho-1D-myo-inositol-pentakisphosphate

ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate

3 entries

additional information

?

-

11 entries

1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP

1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP

Homo sapiens

-

-

717780

-

-

?

1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ATP

1,5-bisdiphospho-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP

Saccharomyces cerevisiae

-

-

717780

-

-

?

3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + ATP

3,5-bisdiphospho-1D-myo-inositol 1,2,4,6-tetrakisphosphate + ADP

Homo sapiens

-

-

717780

-

-

?

3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + ATP

3,5-bisdiphospho-1D-myo-inositol 1,2,4,6-tetrakisphosphate + ADP

Saccharomyces cerevisiae

-

-

717780

-

-

?

5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP

3,5-bisdiphospho-1D-myo-inositol 1,2,4,6-tetrakisphosphate + ADP

Homo sapiens

-

-

717780

-

-

?

5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP

3,5-bisdiphospho-1D-myo-inositol 1,2,4,6-tetrakisphosphate + ADP

Saccharomyces cerevisiae

-

-

717780

-

-

?

ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate

ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate

Homo sapiens

Q6PFW1

-

760744

-

-

?

ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate

ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate

Homo sapiens

O43314

i.e. non-natural enantiomer of 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate

762487

-

-

?

ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate

ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate

Rattus norvegicus

-

-

645048

-

-

?

ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate

ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate

Homo sapiens

Q6PFW1

-

760744

-

-

r

ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate

ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate

Homo sapiens

O43314

-

738042, 762215

-

-

?

ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate

ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate

Homo sapiens

O43314

-

762487

-

-

r

ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate

ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate

Homo sapiens

O43314, Q6PFW1

-

698737

-

-

?

ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate

ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate

Homo sapiens

Q6PFW1

-

698738

-

-

?

ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate

ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate

Homo sapiens

Q6PFW1

(PP)2-InsP4 synthesis pathway, overview

698738

-

-

?

ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate

ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate

Rattus norvegicus

P0C644

-

698738

-

-

?

ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate

ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate

Rattus norvegicus

P0C644

(PP)2-InsP4 synthesis pathway, overview

698738

-

-

?

ATP + 5-diphospho-1D-myo-inositol pentakisphosphate

ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate

Mesocricetus auratus

-

-

662914

-

-

?

ATP + 5-diphospho-1D-myo-inositol pentakisphosphate

ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate

Mesocricetus auratus

-

bis(diphospho)-1D-myo-inositol tetrakisphosphate specifically impedes protein trafficking, no regulation by extracellular signal-regulated kinase or phopholipase D

662914

-

-

?

ATP + 5-diphospho-1D-myo-inositol-pentakisphosphate

ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate

Rattus norvegicus

-

-

642551, 645048

-

-

?

ATP + 5-diphospho-1D-myo-inositol-pentakisphosphate

ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate

Rattus norvegicus

-

-

645048

-

645048

?

ATP + 5-diphospho-1D-myo-inositol-pentakisphosphate

ADP + bis(diphospho)-1D-myo-inositol tetrakisphosphate

Rattus norvegicus

-

-

645049

-

-

?

additional information

?

-

Homo sapiens

O43314

VIP1 also performs the reaction of EC 2.7.4.21

698737

-

-

?

additional information

?

-

Homo sapiens

Q6PFW1

VIP1 also performs the reaction of EC 2.7.4.21

698737

-

-

?

additional information

?

-

Homo sapiens

-

VIP1 also performs the reaction of EC 2.7.4.21

698737

-

-

?

additional information

?

-

Homo sapiens

O43314

VIP2 also performs the reaction of EC 2.7.4.21

698737

-

-

?

additional information

?

-

Homo sapiens

Q6PFW1

VIP2 also performs the reaction of EC 2.7.4.21

698737

-

-

?

additional information

?

-

Homo sapiens

-

VIP2 also performs the reaction of EC 2.7.4.21

698737

-

-

?

additional information

?

-

Homo sapiens

-

recombinant Vip1 kinase domain catalyzes 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate formation from inositol hexakisphosphate. NMR substrate and product analysis, overview

717780

-

-

?

additional information

?

-

Homo sapiens

O43314

the bifunctional enzyme also catalyzes the reaction of EC 2.7.4.21, InsP6 kinase. The enzyme exhibits an unusual, nonproductive, substrate-stimulated ATPase activity, that is stimulated by the natural substrates and by 5-O-alpha-phosphonoacetyl-myo-inositol 1,2,3,4,6-pentakisphosphate and 2-O-benzyl-5-O-alpha-phosphonoacetyl-myo-inositol 1,3,4,6-tetrakisphosphate. It also shows 1,5-[PP]2-InsP4 dephosphorylation activity. The enzyme has two adjacent ligand-binding sites, the architecture of this second ligand-binding site is represented by a deep cleft, which is walled on one side by K53, K54, and K103. The opposite face is formed from R213, and a loop created from residues E192 to H194

738042

-

-

?

additional information

?

-

Homo sapiens

O43314

enzyme additionally catalyzes the reaction of EC 2.7.4.21, i.e. conversion of 1D-myo-inositol hexakisphosphate to 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate. The kinase activities toward 1D-myo-inositol hexakisphosphate are 4fold lower than the kinase activites toward -diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate

761474

-

-

-

additional information

?

-

Homo sapiens

Q6PFW1

enzyme additionally catalyzes the reaction of EC 2.7.4.21, i.e. conversion of 1D-myo-inositol hexakisphosphate to 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate. The kinase activities toward 1D-myo-inositol hexakisphosphate are 4fold lower than the kinase activites toward -diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate

761474

-

-

-

additional information

?

-

Saccharomyces cerevisiae

-

recombinant Vip1 kinase domain catalyzes 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate formation from inositol hexakisphosphate. NMR substrate and product analysis, overview

717780

-

-

?