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2.7.4.3: adenylate kinase

This is an abbreviated version!
For detailed information about adenylate kinase, go to the full flat file.

Word Map on EC 2.7.4.3

Reaction

ATP
+
AMP
=
2 ADP

Synonyms

5'-AMP-kinase, ABC adenylate kinase, AD-004 like protein, adenosine 5'-triphosphate:adenosine 5'-monophosphate phosphotransferase, adenylate kinase, adenylate kinase 1, adenylate kinase 2, adenylate kinase 4, adenylate kinase 5, adenylate kinase 6, adenylate kinase 9, adenylate kinase isoenzyme 1, adenylate kinase isozyme 2, adenylate kinase-2, adenylate kinase-like protein 1, adenylic kinase, adenylokinase, ADK, ADK1, ADK2, ADLP, AK1, AK2, AK4, AK5, AK5p1, AK5p2, AK6, AK7, AK8, AK9, AKE, AKlse4, AKm, AKmeso, AKp, AKpsycrho, AKthermo, ATP:AMP phosphotransferase, CFTR, CINAP, coilin interacting nuclear ATPase protein, cystic fibrosis transmembrane conductance regulator, DAK2, Dak6, kinase, adenylate (phosphorylating), kinase, myo- (phosphorylating), MeADK1, MeADK2, MJ0458, myokinase, nonstructural protein 4B, NS4B, pfSMCnbd, phosphotransferase, Rv0733, Saci_0573, SpAdK, structural maintenance of chromosome protein

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.4 Phosphotransferases with a phosphate group as acceptor
                2.7.4.3 adenylate kinase

Activating Compound

Activating Compound on EC 2.7.4.3 - adenylate kinase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(NH4)2SO4
-
inhibitory above 30 mM, activates below
2-mercaptoethanol
-
activation
2-oxoglutarate
-
activation
ADP
-
induction of cellular ATP production via adenylate kinase resulting in regulation of ADP-dependent endocytosis of high-density lipoprotein
alanine
-
activation
AMP
-
adenylate kinase activation by ATP and AMP stimulates K/ATP channel activity and this stimulation is abolished by adenylate kinase inhibitors
ATP
-
adenylate kinase activation by ATP and AMP stimulates K/ATP channel activity and this stimulation is abolished by adenylate kinase inhibitors
CDP
-
activation
cis-aconitate
-
activation
citrate
dithiothreitol
fumarate
-
activation
GDP
-
activation
isocitrate
-
activation
KCl
-
activation
L-cysteine
L-histidine
-
activation
malate
-
activation
NH4Cl
-
activation
Prostaglandins
-
activation
-
sulfhydryl compounds
-
requirement
TDP
-
activation
Thermolysin
significant increase of specific activity (1.5-fold) after a short (60 min, 50 °C) proteolytic treatment with thermolysin
-
threonine
-
activation
UDP
-
activation
Urea
-
up to 1 M, 60% increase in activity
additional information
-