2.7.4.3: adenylate kinase
This is an abbreviated version!
For detailed information about adenylate kinase, go to the full flat file.
Word Map on EC 2.7.4.3
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2.7.4.3
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phosphoenolpyruvate
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adp
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creatine
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hpr
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fructose
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nucleoside
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permease
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streptococcus
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phosphoenolpyruvate-dependent
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mannose
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6-phosphate
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catabolite
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deaminase
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lactose
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mannitol
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hexokinase
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mutans
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glucose-6-phosphate
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camp-dependent
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aminoglycoside
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autophosphorylation
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phosphoglucomutase
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phosphofructokinase
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kanamycin
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neomycin
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6-phosphogluconate
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phosphorelay
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5'-nucleotidase
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antiterminator
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mgatp
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2-deoxyglucose
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intermembrane
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transphosphorylation
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gamma-phosphate
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melibiose
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salivarius
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ganciclovir
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phosphocreatine
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nptii
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diadenosine
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diphosphohydrolase
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gamma-32patp
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p-loop
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2.7.3.2
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dikinase
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coarse-grained
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analysis
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phosvitin
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medicine
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2,6-bisphosphate
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mucolipidosis
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phosphoenzyme
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diagnostics
- 2.7.4.3
- phosphoenolpyruvate
- adp
- creatine
- hpr
- fructose
- nucleoside
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permease
- streptococcus
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phosphoenolpyruvate-dependent
- mannose
- 6-phosphate
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catabolite
- deaminase
- lactose
- mannitol
- hexokinase
- mutans
- glucose-6-phosphate
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camp-dependent
- aminoglycoside
- autophosphorylation
- phosphoglucomutase
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phosphofructokinase
- kanamycin
- neomycin
- 6-phosphogluconate
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phosphorelay
- 5'-nucleotidase
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antiterminator
- mgatp
- 2-deoxyglucose
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intermembrane
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transphosphorylation
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gamma-phosphate
- melibiose
- salivarius
- ganciclovir
- phosphocreatine
- nptii
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diadenosine
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diphosphohydrolase
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gamma-32patp
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p-loop
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2.7.3.2
- dikinase
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coarse-grained
- analysis
- phosvitin
- medicine
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2,6-bisphosphate
- mucolipidosis
- phosphoenzyme
- diagnostics
Reaction
Synonyms
5'-AMP-kinase, ABC adenylate kinase, AD-004 like protein, adenosine 5'-triphosphate:adenosine 5'-monophosphate phosphotransferase, adenylate kinase, adenylate kinase 1, adenylate kinase 2, adenylate kinase 4, adenylate kinase 5, adenylate kinase 6, adenylate kinase 9, adenylate kinase isoenzyme 1, adenylate kinase isozyme 2, adenylate kinase-2, adenylate kinase-like protein 1, adenylic kinase, adenylokinase, ADK, ADK1, ADK2, ADLP, AK1, AK2, AK4, AK5, AK5p1, AK5p2, AK6, AK7, AK8, AK9, AKE, AKlse4, AKm, AKmeso, AKp, AKpsycrho, AKthermo, ATP:AMP phosphotransferase, CFTR, CINAP, coilin interacting nuclear ATPase protein, cystic fibrosis transmembrane conductance regulator, DAK2, Dak6, kinase, adenylate (phosphorylating), kinase, myo- (phosphorylating), MeADK1, MeADK2, MJ0458, myokinase, nonstructural protein 4B, NS4B, pfSMCnbd, phosphotransferase, Rv0733, Saci_0573, SpAdK, structural maintenance of chromosome protein
ECTree
2.7.4.3 adenylate kinaseAdvanced search results
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results (Inhibitors
Inhibitors on EC 2.7.4.3 - adenylate kinase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
7-deazaadenosine 5'-monophosphate
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i.e. tubercidine 5'-monophosphate
adenosine 5'-(beta,gamma-imido)triphosphate tetralithium
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non-metabolizable ATP analogue, inhibition of adenylate kinase abolishes the stimulatory effect of AMP on K/ATP channels
Ag+
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Ag+ inhibits the adenylate kinase activity from 20% to 60% when its concentration varies from 0.01 to 0.5 mM
cystine
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adenylate kinase activity is diminished in the brain cortex of rats loaded with cystine dimethylester (0.0016 mg/g body weight), co-administration with cysteamine (0.00046 mg/g body weight) prevents inhibition of adenylate kinase caused by cystine
D-glucose
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elevated concentrations of glucose inhibit cytosolic isoform AK1 expression. Inhibition of adenylate kinase increases the ATP/ADP ratio in the microenvironment of the K/ATP channel promoting channel closure and insulin secretion
P1,P4-bis(adenosine-5')tetraphosphate
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inhibitory to both serum adenylate kinase and endothelial adenylate kinase
P1,P4-di(uridine-5')tetraphosphate
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inhibitory to both serum adenylate kinase and endothelial adenylate kinase
P1,P5-(bis adenosine)-5'-pentaphosphate
inhibited activity of the recombinant enzyme, also inhibited the growth of L. donovani promastigotes in vitro
P1,P5-(diadenosine-5')-pentaphosphate
Q14EL6
adenylate kinase-specific inhibitor
sulfur
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elemental sulfur, reversible by dithiothreitol, muscle, not liver isozyme
suramin
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inhibitory to both serum adenylate kinase and endothelial adenylate kinase
uridine adenosine tetraphosphate
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inhibitory to both serum adenylate kinase and endothelial adenylate kinase
(5E)-5-[(2-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
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(5E)-5-[(2-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
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(5E)-5-[(3-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
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(5E)-5-[(3-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
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5,5'-dithiobis(2-nitrobenzoic acid)
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not: mitochondrial enzyme; only cytosolic
5,5'-dithiobis(2-nitrobenzoic acid)
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DTT reverses; strong for muscle enzyme, less effective with dystrophic muscle or liver enzymes
8-anilino-1-naphthalenesulfonic acid
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i.e. ANS, isoform N1 binds rapidly, isoform N2 converts to N1 and binds thereafter
adenosine 5'-pentaphosphate
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inhibits the RAD50 phosphoryl transfer reaction but not ATP hydrolysis
adenosine 5'-pentaphosphate
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inhibits the RAD50 phosphoryl transfer reaction but not ATP hydrolysis
Antibodies against bovine muscle enzyme
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raised in rabbits, inactivation of muscle type, but not liver type enzyme
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Antibodies against bovine muscle enzyme
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raised in rabbits, inactivation of muscle type, but not liver type enzyme
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ascorbate
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at enzyme concentration above 200 nM, no inhibition. At concentrations below 200 nM, adenylate kinase becomes increasingly sensitive to ascorbate inhibition which is accompanied by a deviation from linear relatioship between enzyme concentration and activity to a concave relationship. Aldolase reverse inhibition by ascorbate
diadenosine polyphosphate
inhibits adenylate kinase activity of the nucleotide-binding domains 1 and 2 of CFTR
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diadenosine polyphosphate
inhibits adenylate kinase activity of the nucleotide-binding domain 1 of CFTR
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KCl
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no inhibitory up to 150 mM, 65% residual activity at 700 mM
Mg2+
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strong inhibition in catalyzed reaction is observed when Mg2+concentration is in excess
Mg2+
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at high concentrations; required for enzyme activity at low concentrations
P1,P4-diadenosine tetraphosphate
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i.e. P1,P4-bis(5'-adenosyl)-tetraphosphate, transition state analogue, kinetics
P1,P5-bis(adenosine-5'-)pentaphosphate
i.e. Ap5A, a two substrate-mimicking inhibitor, binding affinity of SpAdK to Ap5A is determined by isothermal titration calorimetry
P1,P5-di(adenosine-5') pentaphosphate
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Ap5A, interacts simultaneously with an AMP-binding site and ATP-binding site 2
P1,P5-di(adenosine-5')pentaphosphate
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inhibitory to Rad50 phosphoryl transfer reaction but not to ATP hydrolysis
P1,P5-di(adenosine-5')pentaphosphate
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inhibitory to both serum adenylate kinase and endothelial adenylate kinase
P1,P5-di(adenosine-5')pentaphosphate
50% inhibition at 50 mM, whether assayed in the direction of ATP formation from ADP or of ATP conversion to ADP
P1,P5-di(adenosine-5')pentaphosphate
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inhibition of adenylate kinase prevents the stimulatory effect of AMP on K/ATP channels
P1,P5-di(adenosine-5')pentaphosphate
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completely abolishes adenylate kinase activity but does not affect ATPase activity
P1,P5-di(adenosine-5')pentaphosphate
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decreases the rate of decomposition of ADP and inhibits the formation of ATP
P1,P5-di(adenosine-5')pentaphosphate
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inhibitory to Rad50 phosphoryl transfer reaction but not to ATP hydrolysis. Inhibitor blocks DNA tethering in vitro and in cell-free extracts
P1,P5-di(adenosine-5')pentaphosphate
50% inhibition at 0.00041 mM, reactivation by 1 mM ADP if concentration of inhibitor is below 0.001 mM. No inhibition if 1 mM ADP is present; 50% inhibition at 0.00053 mM, recombinant enzyme; completely inhibits reactivation of flagella. 1 mM ADP prevents inhibition
P1,P5-diadenosine 5'-pentaphosphate
adenylate kinase-specific inhibitor, potent inhibitor of CINAP
P1,P5-diadenosine 5'-pentaphosphate
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competitive for formation of ADP, noncompetitive for formation of ATP
P1,P5-diadenosine 5'-pentaphosphate
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i.e. AP5A or P1,P5-bis(5'-adenosyl)-pentaphosphate, bisubstrate analogue; kinetics
additional information
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after 2 h from heat-shock, when cell viability remains unaffected, the rate of ADP/ATP exchange due to adenine nucleotide translocator activity, and the activites of adenylate kinase and nucleoside diphosphate kinase are inhibited in a non-competitive like manner. Externally added ascorbate partially prevents inhibition
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additional information
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not inhibitory: P1,P2-di(adenosine-5')diphosphate, P1,P3-di(adenosine-5') triphosphate, triphosphate, tetrahexaphosphate, tetrametaphosphate, hexametaphosphate
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additional information
Q7Z0H0
not inhibitory: atractyloside, chloroquine, primaquine, artemisinine, mefloquine
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additional information
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not inhibitory: atractyloside, chloroquine, primaquine, artemisinine, mefloquine
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additional information
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not inhibitory: p-chloromercuribenzoate
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additional information
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no inhibition by dipyramidole, flufenamic acid, pyridoxal-5-phosphate-6-azophenyl-2,4-disulfonic acid tetrasodium or p-nitrophenylphosphate; not inhibitory: dipyridamole, flufenamic acid, pyridoxal-5-phosphate-6-azophenyl-2',4'-disulphonic acid tetrasodium, and p-nitrophenylphosphate
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additional information
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not inhibitory: p-chloromercuribenzoate
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additional information
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effect of varios intermediary metabolites; no inhibition by K+, Na+, NH4+, AsO2, citrate, NADH, fructose 6-phosphate, 2-phosphoglyceraldehyde
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