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(5E)-5-[(2-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
(5E)-5-[(3-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
(NH4)2SO4
-
above 30 mM, activates below
1,N6-Ethenoadenosine 5'-triphosphate
-
-
3'-O-(4-benzoyl)benzoyl-ATP
-
-
3-phosphoglyceraldehyde
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
7-deazaadenosine 5'-monophosphate
-
i.e. tubercidine 5'-monophosphate
8-anilino-1-naphthalenesulfonic acid
adenosine 5'-(beta,gamma-imido)triphosphate tetralithium
-
non-metabolizable ATP analogue, inhibition of adenylate kinase abolishes the stimulatory effect of AMP on K/ATP channels
adenosine 5'-pentaphosphate
adenosine 5'-tetraphosphate
-
weak
adenosine-5'-pentaphosphate
-
weak
Ag+
-
Ag+ inhibits the adenylate kinase activity from 20% to 60% when its concentration varies from 0.01 to 0.5 mM
Antibodies against bovine muscle enzyme
-
arginine phosphate
-
weak
cystine
-
adenylate kinase activity is diminished in the brain cortex of rats loaded with cystine dimethylester (0.0016 mg/g body weight), co-administration with cysteamine (0.00046 mg/g body weight) prevents inhibition of adenylate kinase caused by cystine
D-glucose
-
elevated concentrations of glucose inhibit cytosolic isoform AK1 expression. Inhibition of adenylate kinase increases the ATP/ADP ratio in the microenvironment of the K/ATP channel promoting channel closure and insulin secretion
diadenosine polyphosphate
-
diphosphate
-
reverse reaction
Methylmercury nitrate
-
-
p-chloromercuriphenylsulfonate
-
-
p-Hydroxymercuribenzene sulfonic acid
-
-
P1,P4-bis(adenosine-5')tetraphosphate
-
inhibitory to both serum adenylate kinase and endothelial adenylate kinase
P1,P4-di(adenosine) tetraphosphate
-
P1,P4-di(adenosine-5') tetraphosphate
-
Ap4A
P1,P4-di(uridine-5')tetraphosphate
-
inhibitory to both serum adenylate kinase and endothelial adenylate kinase
P1,P4-diadenosine tetraphosphate
P1,P5-(bis adenosine)-5'-pentaphosphate
inhibited activity of the recombinant enzyme, also inhibited the growth of L. donovani promastigotes in vitro
P1,P5-(diadenosine-5')-pentaphosphate
Q14EL6
adenylate kinase-specific inhibitor
P1,P5-bis(adenosine-5'-)pentaphosphate
P1,P5-di(adenosine-5') pentaphosphate
P1,P5-di(adenosine-5')pentaphosphate
P1,P5-diadenosine 5'-pentaphosphate
sulfur
-
elemental sulfur, reversible by dithiothreitol, muscle, not liver isozyme
suramin
-
inhibitory to both serum adenylate kinase and endothelial adenylate kinase
Urea
-
plus dithiothreitol and IAA
uridine adenosine tetraphosphate
-
inhibitory to both serum adenylate kinase and endothelial adenylate kinase
(5E)-5-[(2-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
-
(5E)-5-[(2-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
-
(5E)-5-[(3-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
-
(5E)-5-[(3-bromophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
not: liver enzyme
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
not: mitochondrial enzyme; only cytosolic
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
muscle enzyme
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
DTT reverses; strong for muscle enzyme, less effective with dystrophic muscle or liver enzymes
5,5'-dithiobis(2-nitrobenzoic acid)
-
not: liver enzyme
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
5,5'-dithiobis(2-nitrobenzoic acid)
-
DTT reverses; not: mitochondrial enzyme
5,5'-dithiobis(2-nitrobenzoic acid)
-
not
5,5'-dithiobis(2-nitrobenzoic acid)
-
DTT reverses
8-anilino-1-naphthalenesulfonic acid
-
i.e. ANS, isoform N1 binds rapidly, isoform N2 converts to N1 and binds thereafter
8-anilino-1-naphthalenesulfonic acid
-
kinetics
adenosine 5'-pentaphosphate
-
inhibits the RAD50 phosphoryl transfer reaction but not ATP hydrolysis
adenosine 5'-pentaphosphate
-
inhibits the RAD50 phosphoryl transfer reaction but not ATP hydrolysis
ADP
-
in excess, substrate inhibition
ADP
-
in excess, substrate inhibition
ADP
Rhodopseudomonas rubrum
-
in excess, substrate inhibition
Ag2+
-
-
Ag2+
-
predomoninantly muscle type isozymes
Ag2+
-
predomoninantly muscle type isozymes
AMP
-
substrate inhibition
AMP
-
substrate inhibition
AMP
1 mM, complete inhibition of ADP-dependent ATP production
AMP
Rhodopseudomonas rubrum
-
product inhibition
AMP
above 0.007 mM, strong
AMP
-
above 1 mM; substrate inhibition
Antibodies against bovine muscle enzyme
-
raised in rabbits, inactivation of muscle type, but not liver type enzyme
-
Antibodies against bovine muscle enzyme
-
raised in rabbits, inactivation of muscle type, but not liver type enzyme
-
ascorbate
-
at enzyme concentration above 200 nM, no inhibition. At concentrations below 200 nM, adenylate kinase becomes increasingly sensitive to ascorbate inhibition which is accompanied by a deviation from linear relatioship between enzyme concentration and activity to a concave relationship. Aldolase reverse inhibition by ascorbate
Ca2+
51% inhibition at 1 mM
Ca2+
-
51% inhibition at 1 mM
diadenosine polyphosphate
inhibits adenylate kinase activity of the nucleotide-binding domains 1 and 2 of CFTR
-
diadenosine polyphosphate
inhibits adenylate kinase activity of the nucleotide-binding domain 1 of CFTR
-
EDTA
-
and other complexing agents
F-
-
not
F-
Rhodopseudomonas rubrum
-
-
Hg2+
-
-
Hg2+
-
strong, not reaction of ADP + ADP
homologous antibodies
-
-
-
homologous antibodies
-
-
-
homologous antibodies
-
-
-
homologous antibodies
-
-
-
homologous antibodies
-
-
-
IAA
-
not
IAA
-
temperature-dependent
iodoacetate
-
not
iodoacetate
-
temperature-dependent
iodoacetate
Rhodopseudomonas rubrum
-
not
KCl
-
no inhibitory up to 150 mM, 65% residual activity at 700 mM
KCl
Megalodesulfovibrio gigas
-
not inhibitory up to 150 mM, 65% residual activity at 700 mM
Mg2+
-
at a high Mg:ATP ratio
Mg2+
-
strong inhibition in catalyzed reaction is observed when Mg2+concentration is in excess
Mg2+
-
at high concentrations; required for enzyme activity at low concentrations
N-ethylmaleimide
-
-
NADH
-
-
p-hydroxymercuribenzoate
-
-
p-hydroxymercuribenzoate
-
strong, reversible by GSH or cysteine
P1,P4-diadenosine tetraphosphate
-
i.e. P1,P4-bis(5'-adenosyl)-tetraphosphate, transition state analogue, kinetics
P1,P4-diadenosine tetraphosphate
-
weak
P1,P4-diadenosine tetraphosphate
-
-
P1,P5-bis(adenosine-5'-)pentaphosphate
i.e. Ap5A, a two substrate-mimicking inhibitor, binding affinity of SpAdK to Ap5A is determined by isothermal titration calorimetry
P1,P5-bis(adenosine-5'-)pentaphosphate
i.e. Ap5A
P1,P5-di(adenosine-5') pentaphosphate
-
-
P1,P5-di(adenosine-5') pentaphosphate
-
Ap5A, interacts simultaneously with an AMP-binding site and ATP-binding site 2
P1,P5-di(adenosine-5') pentaphosphate
-
-
P1,P5-di(adenosine-5')pentaphosphate
-
1 µM
P1,P5-di(adenosine-5')pentaphosphate
-
-
P1,P5-di(adenosine-5')pentaphosphate
-
inhibitory to Rad50 phosphoryl transfer reaction but not to ATP hydrolysis
P1,P5-di(adenosine-5')pentaphosphate
-
-
P1,P5-di(adenosine-5')pentaphosphate
-
inhibitory to both serum adenylate kinase and endothelial adenylate kinase
P1,P5-di(adenosine-5')pentaphosphate
-
P1,P5-di(adenosine-5')pentaphosphate
-
P1,P5-di(adenosine-5')pentaphosphate
50% inhibition at 50 mM, whether assayed in the direction of ATP formation from ADP or of ATP conversion to ADP
P1,P5-di(adenosine-5')pentaphosphate
-
P1,P5-di(adenosine-5')pentaphosphate
-
P1,P5-di(adenosine-5')pentaphosphate
-
-
P1,P5-di(adenosine-5')pentaphosphate
-
inhibition of adenylate kinase prevents the stimulatory effect of AMP on K/ATP channels
P1,P5-di(adenosine-5')pentaphosphate
Q7Z0H0
-
P1,P5-di(adenosine-5')pentaphosphate
-
completely abolishes adenylate kinase activity but does not affect ATPase activity
P1,P5-di(adenosine-5')pentaphosphate
-
decreases the rate of decomposition of ADP and inhibits the formation of ATP
P1,P5-di(adenosine-5')pentaphosphate
-
inhibitory to Rad50 phosphoryl transfer reaction but not to ATP hydrolysis. Inhibitor blocks DNA tethering in vitro and in cell-free extracts
P1,P5-di(adenosine-5')pentaphosphate
50% inhibition at 0.00041 mM, reactivation by 1 mM ADP if concentration of inhibitor is below 0.001 mM. No inhibition if 1 mM ADP is present; 50% inhibition at 0.00053 mM, recombinant enzyme; completely inhibits reactivation of flagella. 1 mM ADP prevents inhibition
P1,P5-di(adenosine-5')pentaphosphate
-
-
P1,P5-di(adenosine-5')pentaphosphate
-
-
P1,P5-diadenosine 5'-pentaphosphate
-
strong
P1,P5-diadenosine 5'-pentaphosphate
-
kinetics
P1,P5-diadenosine 5'-pentaphosphate
-
weak
P1,P5-diadenosine 5'-pentaphosphate
-
kinetics
P1,P5-diadenosine 5'-pentaphosphate
-
-
P1,P5-diadenosine 5'-pentaphosphate
adenylate kinase-specific inhibitor, potent inhibitor of CINAP
P1,P5-diadenosine 5'-pentaphosphate
-
-
P1,P5-diadenosine 5'-pentaphosphate
-
-
P1,P5-diadenosine 5'-pentaphosphate
-
-
P1,P5-diadenosine 5'-pentaphosphate
-
weak
P1,P5-diadenosine 5'-pentaphosphate
-
above 100 nM; strong
P1,P5-diadenosine 5'-pentaphosphate
-
competitive for formation of ADP, noncompetitive for formation of ATP
P1,P5-diadenosine 5'-pentaphosphate
-
kinetics
P1,P5-diadenosine 5'-pentaphosphate
Rhodopseudomonas rubrum
-
kinetics
P1,P5-diadenosine 5'-pentaphosphate
-
weak
P1,P5-diadenosine 5'-pentaphosphate
-
weak
P1,P5-diadenosine 5'-pentaphosphate
-
-
P1,P5-diadenosine 5'-pentaphosphate
-
specific inhibitor
P1,P5-diadenosine 5'-pentaphosphate
-
i.e. AP5A or P1,P5-bis(5'-adenosyl)-pentaphosphate, bisubstrate analogue; kinetics
phosphoenolpyruvate
-
-
additional information
-
not inhibitory: p-chloromercuribenzoate
-
additional information
-
not inhibitory: p-chloromercuribenzoate
-
additional information
-
not inhibitory: citrate
-
additional information
not inhibited by N-ethylmaleimide
-
additional information
-
not inhibited by N-ethylmaleimide
-
additional information
-
not inhibitory: p-chloromercuribenzoate
-
additional information
-
after 2 h from heat-shock, when cell viability remains unaffected, the rate of ADP/ATP exchange due to adenine nucleotide translocator activity, and the activites of adenylate kinase and nucleoside diphosphate kinase are inhibited in a non-competitive like manner. Externally added ascorbate partially prevents inhibition
-
additional information
-
not inhibitory: p-chloromercuribenzoate
-
additional information
-
not inhibitory: P1,P2-di(adenosine-5')diphosphate, P1,P3-di(adenosine-5') triphosphate, triphosphate, tetrahexaphosphate, tetrametaphosphate, hexametaphosphate
-
additional information
Q7Z0H0
not inhibitory: atractyloside, chloroquine, primaquine, artemisinine, mefloquine
-
additional information
-
not inhibitory: atractyloside, chloroquine, primaquine, artemisinine, mefloquine
-
additional information
-
not inhibitory: p-chloromercuribenzoate
-
additional information
-
-
-
additional information
-
not inhibitory: citrate
-
additional information
-
no inhibition by dipyramidole, flufenamic acid, pyridoxal-5-phosphate-6-azophenyl-2,4-disulfonic acid tetrasodium or p-nitrophenylphosphate; not inhibitory: dipyridamole, flufenamic acid, pyridoxal-5-phosphate-6-azophenyl-2',4'-disulphonic acid tetrasodium, and p-nitrophenylphosphate
-
additional information
-
not inhibitory: p-chloromercuribenzoate
-
additional information
Rhodopseudomonas rubrum
-
not inhibitory: p-chloromercuribenzoate
-
additional information
-
effect of varios intermediary metabolites; no inhibition by K+, Na+, NH4+, AsO2, citrate, NADH, fructose 6-phosphate, 2-phosphoglyceraldehyde
-
additional information
not inhibitory: EDTA 10mM
-
additional information
-
not inhibitory: EDTA 10mM
-