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2.7.4.3: adenylate kinase

This is an abbreviated version!
For detailed information about adenylate kinase, go to the full flat file.

Word Map on EC 2.7.4.3

Reaction

ATP
+
AMP
=
2 ADP

Synonyms

5'-AMP-kinase, ABC adenylate kinase, AD-004 like protein, adenosine 5'-triphosphate:adenosine 5'-monophosphate phosphotransferase, adenylate kinase, adenylate kinase 1, adenylate kinase 2, adenylate kinase 4, adenylate kinase 5, adenylate kinase 6, adenylate kinase 9, adenylate kinase isoenzyme 1, adenylate kinase isozyme 2, adenylate kinase-2, adenylate kinase-like protein 1, adenylic kinase, adenylokinase, ADK, ADK1, ADK2, ADLP, AK1, AK2, AK4, AK5, AK5p1, AK5p2, AK6, AK7, AK8, AK9, AKE, AKlse4, AKm, AKmeso, AKp, AKpsycrho, AKthermo, ATP:AMP phosphotransferase, CFTR, CINAP, coilin interacting nuclear ATPase protein, cystic fibrosis transmembrane conductance regulator, DAK2, Dak6, kinase, adenylate (phosphorylating), kinase, myo- (phosphorylating), MeADK1, MeADK2, MJ0458, myokinase, nonstructural protein 4B, NS4B, pfSMCnbd, phosphotransferase, Rv0733, Saci_0573, SpAdK, structural maintenance of chromosome protein

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.4 Phosphotransferases with a phosphate group as acceptor
                2.7.4.3 adenylate kinase

pH Stability

pH Stability on EC 2.7.4.3 - adenylate kinase

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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1 - 3
-
2 h, up to 15% loss of activity
642582
11.5
-
1 h, at 0°C, quite stable
642559
2
-
1 h, at 0°C, quite stable
642559
3
-
2 h, at 25°C, 75% loss of activity, stable at neutral pH-values, acidic heart enzyme
642569
4.5
-
unstable at
642600
4.5 - 10.5
XP_019937160.1
0°C, 3 h, less than 50% loss of activity
761112
4.5 - 8.5
0°C, 3 h, less than 40% loss of activity
761112
4.6
-
stable overnight
642577
4.8 - 11
5
not at all stable at values below
660952
5 - 11
-
1 h stable, 0.1-0.2 mg/ml, at 0°C
642572
5 - 6
5.6
-
t1/2: 24 h, sodium phosphate buffer
642588
6 - 8
-
10 min, at 90°C, in 10 mM phosphate buffer, pH 7, 0.1 M KCl, DTT, Triton X-100, +/- EDTA, 10% loss of activity within 10 min
642567
6 - 9
-
relatively stable, unstable below pH 5.5
642588
7.4 - 9.3
80% activity
660952
8
-
at least 2 days
642572
9 - 11
Megalodesulfovibrio gigas
-
reduced ability to become renatured upon cooling below and above these pH
661349