2.7.4.8: guanylate kinase

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For detailed information about guanylate kinase, go to the full flat file.

Reaction

Synonyms

5'-GMP kinase, apo-EcGMPK, ATP: GMP phosphotransferase, ATP:GMP phosphotransferase, BmGK, CASK polypeptide, Cavbeta1b, Cavbeta2a, deoxyguanylate kinase, DLG1/SAP97, ecGMPK, GK, GK3, GKc, GKpm, GMK, GMK3, GMP kinase, GMPK, guanosine monophosphate kinase, guanosine monophosphate kinase (EcGMPK), guanylate kinase, guanylate kinase (GK), guanylate monophosphate kinase, GUK, kinase, guanylate (phosphorylating), MAGUK, MAGUK PSD-95, MAGUKs, membrane associated guanylate kinase, membrane associated guanylate kinase protein, membrane-associated guanylate kinase, membrane-associated guanylate kinases, MoGuk1, MoGuk2, More, organellar GK, post-synaptic density-95 membrane associated guanylate kinase, postsynaptic density protein-95 SH3 GK, PSD-95 GK, PSD-95 MAGUK, PSD-95alpha, PSD-95beta, Staphylococcus aureus guanylate monophosphate kinase, voltage-gated calcium channel beta1b, voltage-gated calcium channel beta2a, YGK

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.4 Phosphotransferases with a phosphate group as acceptor

                2.7.4.8 guanylate kinase

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Results	in table
2	Activating Compound
41441	AA Sequence
3	Application
1	CAS Registry Number
31	Cloned(Commentary)
11	Cofactor
12	Crystallization (Commentary)
296	Disease/ Diagnostics
2	Expression
34	General Information
8	General Stability
3	IC50 Value
78	Inhibitors
14	kcat/KM [mM/s]
23	Ki Value [mM]
86	KM Value [mM]
33	Localization
105	Metals/Ions
20	Molecular Weight [Da]
43	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
271	Organism
6	Pathway
83	PDB ID
19	pH Optimum
7	pH Range
3	pH Stability
4	pI Value
4	Posttranslational Modification
24	Protein Variants
37	Purification (Commentary)
4	Reaction
9	Reaction Type
76	Reference
3	Renatured (Commentary)
41	Source Tissue
21	Specific Activity [micromol/min/mg]
17	Storage Stability
217	Substrates and Products (Substrate)
15	Subunits
86	Synonyms
1	Systematic Name
20	Temperature Optimum [°C]
1	Temperature Range [°C]
15	Temperature Stability [°C]
28	Turnover Number [1/s]

Application

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Application on EC 2.7.4.8 - guanylate kinase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

drug development

2 entries

medicine

Escherichia coli

P60546

GMPK from bacterial pathogens, in which this enzyme is essential, are potential targets for therapeutic inhibition.

672440

drug development

Escherichia coli

-

the guanylate-kinase-deficient Escherichia coli strain relies on the presence of a plasmid-borne, functional guanylate kinase for viability. Such a strain will be beneficial to assess the role of specific amino acids of guanylate kinase in structure, function, drug activation, and drug resistance

660690

drug development

Escherichia coli TS202A

-

the guanylate-kinase-deficient Escherichia coli strain relies on the presence of a plasmid-borne, functional guanylate kinase for viability. Such a strain will be beneficial to assess the role of specific amino acids of guanylate kinase in structure, function, drug activation, and drug resistance

-