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2.7.4.8: guanylate kinase

This is an abbreviated version!
For detailed information about guanylate kinase, go to the full flat file.

Word Map on EC 2.7.4.8

Reaction

ATP
+
GMP
=
ADP
 +
GDP

Synonyms

5'-GMP kinase, apo-EcGMPK, ATP: GMP phosphotransferase, ATP:GMP phosphotransferase, BmGK, CASK polypeptide, Cavbeta1b, Cavbeta2a, deoxyguanylate kinase, DLG1/SAP97, ecGMPK, GK, GK3, GKc, GKpm, GMK, GMK3, GMP kinase, GMPK, guanosine monophosphate kinase, guanosine monophosphate kinase (EcGMPK), guanylate kinase, guanylate kinase (GK), guanylate monophosphate kinase, GUK, kinase, guanylate (phosphorylating), MAGUK, MAGUK PSD-95, MAGUKs, membrane associated guanylate kinase, membrane associated guanylate kinase protein, membrane-associated guanylate kinase, membrane-associated guanylate kinases, MoGuk1, MoGuk2, More, organellar GK, post-synaptic density-95 membrane associated guanylate kinase, postsynaptic density protein-95 SH3 GK, PSD-95 GK, PSD-95 MAGUK, PSD-95alpha, PSD-95beta, Staphylococcus aureus guanylate monophosphate kinase, voltage-gated calcium channel beta1b, voltage-gated calcium channel beta2a, YGK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.4 Phosphotransferases with a phosphate group as acceptor
                2.7.4.8 guanylate kinase

Inhibitors

Inhibitors on EC 2.7.4.8 - guanylate kinase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5,5'-dithiobis(2-nitrobenzoate)
6-Selenoguanosine 5'-phosphate
-
GMP-phosphorylation, pI 4.9-isozyme, competitive with respect to GMP
6-Thioguanosine 5'-phosphate
8-azaguanosine 5'-monophosphate
-
(d)GMP-phosphorylation
8-bromoguanosine 5'-monophosphate
-
(d)GMP-phosphorylation
9-(1,3-dihydroxy-2-propylmethyl)guanine 5'-monophosphate
-
-
9-(2-hydroxyethoxymethyl)guanine 5'-monophosphate
-
-
9-(6,6-difluoro-6-phosphonohexyl)guanine
-
competitive with respect to GMP, non-competitive with respect to ATP
9-(6-phosphonohexyl)guanine
-
competitive with respect to GMP, non-competitive with respect to ATP
AMP
-
10-15% inhibition at 5 mM
Ap5G
Ap5G locks an incompletely closed conformation of the enzyme, in which the adenine moiety is located outside its expected binding site. Instead, it binds at a subunit interface that is unique to the bacterial enzyme, which is in equilibrium between a dimeric and an hexameric form in solution.
aurin
82% inhibition at 0.05 mM
CMP
-
10-15% inhibition at 5 mM
Cs+
-
strong
dAMP
-
10-15% inhibition at 5 mM
dCMP
-
10-15% inhibition at 5 mM
diospyrin
-
-
GTP
-
GMP-phosphorylation
guanosine 3',5'-bisdiphosphate
indol-3-acetic acid
-
GMP + ATP protect
N-ethylmaleimide
Ni2+
high inhibition at 1 mM
p-chloromercuribenzoic acid
p-hydroxymercuribenzoate
P1 -(5'-adenosyl)-P5 -(5'-guanosyl)pentaphosphate
a non-hydrolysable bi-substrate analogue
phosphate
-
weak
PMSF
inhibits 65% at 5 mM
suramin
83.5% inhibition at 0.01 mM
UMP
-
10-15% inhibition at 5 mM
Zn2+
high inhibition at 1 mM
additional information
-