2.7.4.8: guanylate kinase

This is an abbreviated version!
For detailed information about guanylate kinase, go to the full flat file.

Word Map on EC 2.7.4.8

2.7.4.8

junction

synapses

drosophila

nmda

cell-cell

src

excitatory

synapse-associated

hippocampal

domain-containing

magi-1

adaptor

spine

palmitoylated

n-methyl-d-aspartate

presynaptic

glutamatergic

kinase-like

adherens

pdz-binding

zonula

carma1

crumbs

bcl10

neurexins

discs-large

dgmp

septate

occludens

kinase-associated

junction-associated

tcr-induced

ampars

shank

mucosa-associated

card-containing

neuroligins

drug development

medicine

Reaction

Synonyms

5'-GMP kinase, apo-EcGMPK, ATP: GMP phosphotransferase, ATP:GMP phosphotransferase, BmGK, CASK polypeptide, Cavbeta1b, Cavbeta2a, deoxyguanylate kinase, DLG1/SAP97, ecGMPK, GK, GK3, GKc, GKpm, GMK, GMK3, GMP kinase, GMPK, guanosine monophosphate kinase, guanosine monophosphate kinase (EcGMPK), guanylate kinase, guanylate kinase (GK), guanylate monophosphate kinase, GUK, kinase, guanylate (phosphorylating), MAGUK, MAGUK PSD-95, MAGUKs, membrane associated guanylate kinase, membrane associated guanylate kinase protein, membrane-associated guanylate kinase, membrane-associated guanylate kinases, MoGuk1, MoGuk2, More, organellar GK, post-synaptic density-95 membrane associated guanylate kinase, postsynaptic density protein-95 SH3 GK, PSD-95 GK, PSD-95 MAGUK, PSD-95alpha, PSD-95beta, Staphylococcus aureus guanylate monophosphate kinase, voltage-gated calcium channel beta1b, voltage-gated calcium channel beta2a, YGK

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.4.8 guanylate kinase

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Results	in table
2	Activating Compound
41441	AA Sequence
3	Application
1	CAS Registry Number
31	Cloned(Commentary)
11	Cofactor
12	Crystallization (Commentary)
296	Disease/ Diagnostics
2	Expression
34	General Information
8	General Stability
3	IC50 Value
78	Inhibitors
14	kcat/KM [mM/s]
23	Ki Value [mM]
86	KM Value [mM]
33	Localization
105	Metals/Ions
20	Molecular Weight [Da]
43	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
271	Organism
6	Pathway
83	PDB ID
19	pH Optimum
7	pH Range
3	pH Stability
4	pI Value
4	Posttranslational Modification
24	Protein Variants
37	Purification (Commentary)
4	Reaction
9	Reaction Type
76	Reference
3	Renatured (Commentary)
41	Source Tissue
21	Specific Activity [micromol/min/mg]
17	Storage Stability
217	Substrates and Products (Substrate)
15	Subunits
86	Synonyms
1	Systematic Name
20	Temperature Optimum [°C]
1	Temperature Range [°C]
15	Temperature Stability [°C]
28	Turnover Number [1/s]

KI Value

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KI Value on EC 2.7.4.8 - guanylate kinase

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0.043 - 0.067

9-(1,3-dihydroxy-2-propylmethyl)guanine 5'-monophosphate

4 entries

0.45 - 0.84

9-(2-hydroxyethoxymethyl)guanine 5'-monophosphate

4 entries

0.14

9-(6,6-difluoro-6-phosphonohexyl)guanine

Sus scrofa

pH 7.5, 30ºC, higher affinity than 9-(6-phosphonohexyl)guanine for guanylate kinases al pH values below 7.5

642697

0.11

9-(6-phosphonohexyl)guanine

Sus scrofa

pH 7.5, 30ºC

642697

0.148 - 0.57

dGMP

3 entries

0.215

GDP

Saccharomyces cerevisiae

pH 7.5, 25ºC

642701

0.035 - 0.63

GMP

4 entries

0.0028

guanosine 3',5'-bisdiphosphate

Oryza sativa Japonica Group

Q10M74, Q2QPW1

versus GMP, pH 7.5, 30°C

738614

0.037

MgADP-

Saccharomyces cerevisiae

pH 7.5, 25ºC

642701

0.08 - 0.16

MgATP2-

3 entries