2.7.4.8: guanylate kinase

This is an abbreviated version!
For detailed information about guanylate kinase, go to the full flat file.

Word Map on EC 2.7.4.8

2.7.4.8

junction

synapses

drosophila

nmda

cell-cell

src

excitatory

synapse-associated

hippocampal

domain-containing

magi-1

adaptor

spine

palmitoylated

n-methyl-d-aspartate

presynaptic

glutamatergic

kinase-like

adherens

pdz-binding

zonula

carma1

crumbs

bcl10

neurexins

discs-large

dgmp

septate

occludens

kinase-associated

junction-associated

tcr-induced

ampars

shank

mucosa-associated

card-containing

neuroligins

drug development

medicine

Reaction

Synonyms

5'-GMP kinase, apo-EcGMPK, ATP: GMP phosphotransferase, ATP:GMP phosphotransferase, BmGK, CASK polypeptide, Cavbeta1b, Cavbeta2a, deoxyguanylate kinase, DLG1/SAP97, ecGMPK, GK, GK3, GKc, GKpm, GMK, GMK3, GMP kinase, GMPK, guanosine monophosphate kinase, guanosine monophosphate kinase (EcGMPK), guanylate kinase, guanylate kinase (GK), guanylate monophosphate kinase, GUK, kinase, guanylate (phosphorylating), MAGUK, MAGUK PSD-95, MAGUKs, membrane associated guanylate kinase, membrane associated guanylate kinase protein, membrane-associated guanylate kinase, membrane-associated guanylate kinases, MoGuk1, MoGuk2, More, organellar GK, post-synaptic density-95 membrane associated guanylate kinase, postsynaptic density protein-95 SH3 GK, PSD-95 GK, PSD-95 MAGUK, PSD-95alpha, PSD-95beta, Staphylococcus aureus guanylate monophosphate kinase, voltage-gated calcium channel beta1b, voltage-gated calcium channel beta2a, YGK

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.4.8 guanylate kinase

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Results	in table
2	Activating Compound
41441	AA Sequence
3	Application
1	CAS Registry Number
31	Cloned(Commentary)
11	Cofactor
12	Crystallization (Commentary)
296	Disease/ Diagnostics
2	Expression
34	General Information
8	General Stability
3	IC50 Value
78	Inhibitors
14	kcat/KM [mM/s]
23	Ki Value [mM]
86	KM Value [mM]
33	Localization
105	Metals/Ions
20	Molecular Weight [Da]
43	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
271	Organism
6	Pathway
83	PDB ID
19	pH Optimum
7	pH Range
3	pH Stability
4	pI Value
4	Posttranslational Modification
24	Protein Variants
37	Purification (Commentary)
4	Reaction
9	Reaction Type
76	Reference
3	Renatured (Commentary)
41	Source Tissue
21	Specific Activity [micromol/min/mg]
17	Storage Stability
217	Substrates and Products (Substrate)
15	Subunits
86	Synonyms
1	Systematic Name
20	Temperature Optimum [°C]
1	Temperature Range [°C]
15	Temperature Stability [°C]
28	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 2.7.4.8 - guanylate kinase

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20000

3 entries

20500

Rattus norvegicus

gel filtration

642686

20548

Saccharomyces cerevisiae

1 * 20548, calculated from amino acid sequence

642691

21700

Homo sapiens

deduced from the amino acid composition

642700

21900

Mus musculus

Q64520

deduced from the amino acid composition

22000

22010

deduced from the amino acid composition and detected by mass spectrometry, adducts with sulfate and not phosphate are detected in mass spectrometry

23000

1 * 23000, SDS-PAGE

23460

monomer, electrospray ionization-mass spectrometry

662657

23462

Escherichia coli

P60546

x * 23462, thermodynamic analysis, the enzyme is in equilibrium between a dimer and higher order oligomers, whose relative amounts depend on protein concentration, ionic strength, and the presence of ATP

662657

24000

2 entries

25000

Saccharomyces cerevisiae

gel filtration

45000

gel filtration

72000

gel filtration

88000

equilibrium centrifugation

642687