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2.7.4.8: guanylate kinase

This is an abbreviated version!
For detailed information about guanylate kinase, go to the full flat file.

Word Map on EC 2.7.4.8

Reaction

ATP
+
GMP
=
ADP
+
GDP

Synonyms

5'-GMP kinase, apo-EcGMPK, ATP: GMP phosphotransferase, ATP:GMP phosphotransferase, BmGK, CASK polypeptide, Cavbeta1b, Cavbeta2a, deoxyguanylate kinase, DLG1/SAP97, ecGMPK, GK, GK3, GKc, GKpm, GMK, GMK3, GMP kinase, GMPK, guanosine monophosphate kinase, guanosine monophosphate kinase (EcGMPK), guanylate kinase, guanylate kinase (GK), guanylate monophosphate kinase, GUK, kinase, guanylate (phosphorylating), MAGUK, MAGUK PSD-95, MAGUKs, membrane associated guanylate kinase, membrane associated guanylate kinase protein, membrane-associated guanylate kinase, membrane-associated guanylate kinases, MoGuk1, MoGuk2, More, organellar GK, post-synaptic density-95 membrane associated guanylate kinase, postsynaptic density protein-95 SH3 GK, PSD-95 GK, PSD-95 MAGUK, PSD-95alpha, PSD-95beta, Staphylococcus aureus guanylate monophosphate kinase, voltage-gated calcium channel beta1b, voltage-gated calcium channel beta2a, YGK

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.4 Phosphotransferases with a phosphate group as acceptor
                2.7.4.8 guanylate kinase

Substrates Products

Substrates Products on EC 2.7.4.8 - guanylate kinase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
aciclovir (ACV-MP)
?
show the reaction diagram
-
-
-
-
?
ATP + (R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4-hydroxybutylphosphonic acid
(R)-ganciclovir phosphonate monophosphate
show the reaction diagram
ATP + (R)-ganciclovir phosphonate
?
show the reaction diagram
-
-
-
-
?
ATP + 6-thioguanosine 5'-monophosphate
ADP + 8-thioguanosine 5'-diphosphate
show the reaction diagram
ATP + 8-azaguanosine 5'-monophosphate
ADP + 8-azaguanosine 5'-diphosphate
show the reaction diagram
ATP + 8-bromoguanosine 5'-monophosphate
ADP + 8-bromoguanosine 5'-diphosphate
show the reaction diagram
-
poor substrate
-
-
?
ATP + 9-(1,3-dihydroxy-2-propoxymethyl)guanine 5'-monophosphate
ADP + 9-(1,3-dihydroxy-2-propoxymethyl)guanine 5'-diphosphate
show the reaction diagram
-
no substrate: 9-(5,5-difluoro-5-phosphonopentyl)guanine 5'-monophosphate
-
-
?
ATP + 9-(2-hydroxyethoxymethyl)guanine 5'-monophosphate
ADP + 9-(2-hydroxyethoxymethyl)guanine 5'-diphosphate
show the reaction diagram
-
i.e. acyclovir 5'-monophosphate
-
-
?
ATP + 9-(5-phosphonopentyl)guanine
?
show the reaction diagram
-
9-(5,5'-difluoro-5-phosphonopenthyl)guanine is not a substrate
-
-
?
ATP + AMP
2 ADP
show the reaction diagram
-
-
-
-
?
ATP + AMP
ADP + ADP
show the reaction diagram
-
very low activity with AMP
-
-
?
ATP + dGMP
ADP + dGDP
show the reaction diagram
ATP + ganciclovir
ADP + ganciclovir phosphate
show the reaction diagram
-
-
-
-
?
ATP + ganciclovir monophosphate
?
show the reaction diagram
-
-
-
-
?
ATP + ganciclovir monophosphate
ADP + ganciclovir-diphosphate
show the reaction diagram
-
-
-
-
?
ATP + GDP
ADP + GTP
show the reaction diagram
ATP + GMP
ADP + GDP
show the reaction diagram
ATP + IMP
ADP + IDP
show the reaction diagram
-
very poor substrate
-
-
?
dATP + dGMP
dADP + dGDP
show the reaction diagram
dATP + GMP
dADP + GDP
show the reaction diagram
dGMP + ATP
dGDP + ADP
show the reaction diagram
GDP + GDP
GTP + GMP
show the reaction diagram
-
-
?
GMP + ATP
GDP + ADP
show the reaction diagram
GMP + MgATP2-
MgADP- + GDP
show the reaction diagram
GTP + dAMP
GDP + dADP
show the reaction diagram
-
-
-
r
GTP + GDP
GMP + guanosine 5'-tetraphosphate
show the reaction diagram
-
-
?
guanosine monophosphate + adenosine triphosphate
guanosine diphosphate + adenosine diphosphate
show the reaction diagram
additional information
?
-