2.7.4.9: dTMP kinase
This is an abbreviated version!
For detailed information about dTMP kinase, go to the full flat file.
Reaction
Synonyms
ATP: TMP phosphotransferase, Cdc8, deoxythymidine 5'-monophosphate kinase, deoxythymidine monophosphate kinase, dTMP kinase, dTMP kinases, dTMPK, human thymidine monophosphate kinase (hTMPK), kinase, thymidine monophosphate (phosphorylating), kinase, thymidylate (phosphorylating), ORF454, PfTMK, S. aureus thymidylate kinase, thymidine 5'-monophosphate kinase, thymidine kinase, thymidine monophosphate kinase, thymidylate kinase, thymidylate monophosphate kinase, thymidylic acid kinase, thymidylic kinase, TK1, TMK, TMP kinase, TMPK, TMPKmt, TTHA1607, TYMK
ECTree
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Metals Ions
Metals Ions on EC 2.7.4.9 - dTMP kinase
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Co2+
Mg2+
Mn2+
Ni2+
additional information
presence of a divalent cation is required. In presence of Ca2+, Cu2+, less than 10% of maximum activity, no activity with Zn2+
Mg2+
-
absolute requirement for divalent cation. When Mg2+ is equal to ATP, the rate of dTMP kinase reaction is maximal
Mg2+
-
requirement of a Mg2+:ATP ratio greater than 1.0 and for optimal activity there is a requirement of an additional 2-3 mM Mg2+ above the concentration of ATP
Mg2+
-
required, concentration range for maximal activity is From Mg:ATP ratios of 1 to 3 with an optimum around 1.3 to 1.5
Mg2+
bound to enzyme, displacement of Mg2+ is responsible for inhibitory effect of 3-azido-3-deoxythymidine 5'-monophosphate
Mg2+
bound to enzyme, displacement of Mg2+ might be responsible for inhibitory effect of the enzyme inhibitors
Mg2+
-
bound to enzyme, displacement of Mg2+ might be responsible for inhibitory effect of the enzyme inhibitors
Mg2+
-
activity is maximal in presence of 2-5 mM ATP and 10 mM MgCl2