2.7.4.9: dTMP kinase

This is an abbreviated version!
For detailed information about dTMP kinase, go to the full flat file.

Word Map on EC 2.7.4.9

2.7.4.9

tuberculosis

nucleoside

deoxycytidine

dtdp

aztmp

medicine

drug development

Reaction

Synonyms

ATP: TMP phosphotransferase, Cdc8, deoxythymidine 5'-monophosphate kinase, deoxythymidine monophosphate kinase, dTMP kinase, dTMP kinases, dTMPK, human thymidine monophosphate kinase (hTMPK), kinase, thymidine monophosphate (phosphorylating), kinase, thymidylate (phosphorylating), ORF454, PfTMK, S. aureus thymidylate kinase, thymidine 5'-monophosphate kinase, thymidine kinase, thymidine monophosphate kinase, thymidylate kinase, thymidylate monophosphate kinase, thymidylic acid kinase, thymidylic kinase, TK1, TMK, TMP kinase, TMPK, TMPKmt, TTHA1607, TYMK

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.4 Phosphotransferases with a phosphate group as acceptor

2.7.4.9 dTMP kinase

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Results	in table
1	Activating Compound
45422	AA Sequence
12	Application
1	CAS Registry Number
29	Cloned(Commentary)
9	Cofactor
23	Crystallization (Commentary)
179	Disease/ Diagnostics
23	General Information
8	General Stability
178	IC50 Value
502	Inhibitors
18	kcat/KM [mM/s]
198	Ki Value [mM]
101	KM Value [mM]
15	Localization
29	Metals/Ions
21	Molecular Weight [Da]
29	Natural Substrates/ Products (Substrates)
298	Organism
11	Pathway
232	PDB ID
9	pH Optimum
6	pH Range
3	pH Stability
29	Protein Variants
27	Purification (Commentary)
3	Reaction
4	Reaction Type
107	Reference
1	Renatured (Commentary)
23	Source Tissue
11	Specific Activity [micromol/min/mg]
4	Storage Stability
215	Substrates and Products (Substrate)
21	Subunits
99	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Temperature Range [°C]
14	Temperature Stability [°C]
63	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.7.4.9 - dTMP kinase

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ATP + dTMP

ADP + dTDP

15 entries

ATP + thymidine

ADP + TMP

2 entries

ATP + TMP

ADP + TDP

3 entries

dTMP + ATP

dTDP + ADP

Mycobacterium tuberculosis variant bovis

TMPK catalyzes the conversion of dTMP to dTDP, using ATP as its preferred phosphoryl donor. Part of the biosynthetic pathway for deoxythymidine triphosphate (dTTP).

673092

L-dTMP + ATP

L-dTDP + ADP

Homo sapiens

P23919

676227

thymidine monophosphate + ATP

thymidine diphosphate + ADP

Staphylococcus aureus

Thymidylate kinase (TMK) (E.C. 2.7.4.9) is a member of the NMP kinase family and catalyzes the phosphoryl transfer from the preferred phosphoryl donor, ATP, to thymidine monophosphate (TMP), yielding thymidine diphosphate (TDP). The TMK reaction is positioned at the junction of the de novo and salvage pathway of thymidine triphosphate (dTTP) synthesis, with TMK being the last specific enzyme for dTTP synthesis.

677021

additional information

4 entries