2.7.4.9: dTMP kinase
This is an abbreviated version!
For detailed information about dTMP kinase, go to the full flat file.
Word Map on EC 2.7.4.9
Reaction
Synonyms
ATP: TMP phosphotransferase, Cdc8, deoxythymidine 5'-monophosphate kinase, deoxythymidine monophosphate kinase, dTMP kinase, dTMP kinases, dTMPK, human thymidine monophosphate kinase (hTMPK), kinase, thymidine monophosphate (phosphorylating), kinase, thymidylate (phosphorylating), ORF454, PfTMK, S. aureus thymidylate kinase, thymidine 5'-monophosphate kinase, thymidine kinase, thymidine monophosphate kinase, thymidylate kinase, thymidylate monophosphate kinase, thymidylic acid kinase, thymidylic kinase, TK1, TMK, TMP kinase, TMPK, TMPKmt, TTHA1607, TYMK
ECTree
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Reference on EC 2.7.4.9 - dTMP kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bone, R.; Cheng, Y.C.; Wolfenden, R.
Inhibition of adenosine and thymidylate kinases by bisubstrate analogs
J. Biol. Chem.
261
16410-16413
1986
Homo sapiens
Kielley, R.K.
Purification and properties of thymidine monophosphate kinase from mouse hepatoma
J. Biol. Chem.
245
4204-4212
1970
Mus musculus
Tamiya, N.; Yusa, T.; Yamaguchi, Y.; Tsukifuji, R.; Kuroiwa, N.; Moriyama, Y.; Fujimura, S.
Co-purification of thymidylate kinase and cytosolic thymidine kinase from human term placenta by affinity chromatography
Biochim. Biophys. Acta
995
28-35
1989
Homo sapiens
Jong, A.Y.S.; Campbell, J.L.
Characterization of Saccharomyces cerevisiae thymidylate kinase, the CDC8 gene product. General properties, kinetic analysis, and subcellular localization
J. Biol. Chem.
259
14394-14398
1984
Saccharomyces cerevisiae
Chen, M.C.; Walker, J.; Prusoff, W.H.
Kinetic studies of herpes simplex virus type 1-encoded thymidine and thymidylate kinase, a multifunctional enzyme
J. Biol. Chem.
254
10747-10753
1979
Human alphaherpesvirus 1
Lee, L.S.; Cheng, Y.C.
Human thymidylate kinase. Purification, characterization, and kinetic behavior of the thymidylate kinase derived from chronic myelocytic leukemia
J. Biol. Chem.
252
5686-5691
1977
Homo sapiens
Smith, L.K.; Eakin, R.E.
Partial purification and characterization of thymidylate kinase from embryonic chick liver
Arch. Biochem. Biophys.
167
61-71
1975
Gallus gallus
Rossi, M.; Woodward, D.O.
Enzymes of deoxythymidine triphosphate biosynthesis in Neurospora crassa mitochondria
J. Bacteriol.
121
640-647
1975
Neurospora crassa
Cheng, Y.C.; Prusoff, W.H.
Mouse ascites sarcoma 180 thymidylate kinase. General properties, kinetic analysis, and inhibition studies
Biochemistry
12
2612-2619
1973
Mus musculus
de Groot, E.J.; Schweiger, H.G.
Thymidylate kinase from Acetabularia. I. Properties of the enzyme
J. Cell Sci.
64
13-25
1983
Acetabularia acetabulum
Nelson, D.J.; Carter, C.E.
Purification and characterization of Thymidine 5-monophosphate kinase from Escherichia coli B
J. Biol. Chem.
244
5254-5262
1969
Escherichia coli, Escherichia coli B / ATCC 11303
Jong, A.Y.S.; Kuo, C.l.; Campbell, J.L.
The CDC8 gene of yeast encodes thymidylate kinase
J. Biol. Chem.
259
11052-11059
1984
Saccharomyces cerevisiae
Ostermann, N.; Segura-Pena, D.; Meier, C.; Veit, T.; Monnerjahn, C.; Konrad, M.; Lavie, A.
Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry
42
2568-2577
2003
Homo sapiens (P23919), Homo sapiens
Chenal-FRancisque, V.; Tourneux, L.; carniel, E.; Christova, P.; de la Sierra, I.; Barzu, O.; Gilles, A.M.
The highly similar TMP kinase of Yersinia pestis and Escherichia coli differ markedly in their ATTMP phosphorylating activity
Eur. J. Biochem.
265
112-119
1999
Escherichia coli, Yersinia pestis
Tourneux, L.; Bucurenci, N.; Lascu, I.; sakamoto, H.; Briand, G.; Gilles, A.M.
Substitution of an alanine residue for glycine 146 in TMP kinase from Escherichia coli is responsible for bacterial hypersensitivity to bromodeoxyuridine
J. Bacteriol.
180
4291-4293
1998
Escherichia coli
Petit, C.M.; Koretke, K.K.
Characterization of Streptococcus pneumoniae thymidylate kinase: steady-state kinetics of the forward reaction and isothermal titration calorimetry
Biochem. J.
363
825-831
2002
Streptococcus pneumoniae
Fioravanti, E.; Haouz, A.; Ursby, T.; Munier-Lehmann, H.; Delarue, M.; Bourgeois, D.
Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway
J. Mol. Biol.
327
1077-1092
2003
Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis
terentyev, L.L.; Terentyeva, N.A.; Rasskazov, V.A.
Purification and some properties of thymidylate kinase from sea urchin
Biochemistry
64
80-85
1999
Strongylocentrotus intermedius
Jacobsson, B.; Britton, S.; Törnevik, Y.; Eriksson, S.
Decreas in thymidylate kinase activity in peripheral blood mononuclear cells from HIV-infected individuals
Biochem. Pharmacol.
56
389-395
1998
Homo sapiens
Munier-lehmann, H.; Chaffotte, A.; Pochet, S.; Labesse, G.
Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes
Protein Sci.
10
1195-1205
2001
Mycobacterium tuberculosis
Ostermann, N.; Schlichting, I.; Brundiers, R.; Konrad, M.; Reinstein, J.; Veit, T.; Goody, R.S.; Lavie, A.
Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate
Structure
8
629-642
2000
Homo sapiens
Fioravanti, E.; Adam, V.; Munier-Lehmann, H.; Bourgeois, D.
The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3'-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition
Biochemistry
44
130-137
2005
Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis
Pochet, S.; Dugue, L.; Labesse, G.; Delepierre, M.; Munier-Lehmann, H.
Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans
ChemBioChem
4
742-747
2003
Homo sapiens, Mycobacterium tuberculosis
Haouz, A.; Vanheusden, V.; Munier-Lehmann, H.; Froeyen, M.; Herdewijn, P.; Van Calenbergh, S.; Delarue, M.
Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism
J. Biol. Chem.
278
4963-4971
2003
Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis
Vanheusden, V.; Munier-Lehmann, H.; Froeyen, M.; Busson, R.; Rozenski, J.; Herdewijn, P.; Van Calenbergh, S.
Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase
J. Med. Chem.
47
6187-6194
2004
Homo sapiens, Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis
Lavie, A.; Konrad, M.
Structural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase
Mini Rev. Med. Chem.
4
351-359
2004
Homo sapiens
Munier-Lehmann, H.; Pochet, S.; Dugue, L.; Dutruel, O.; Labesse, G.; Douget, D.
Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors
Nucleosides Nucleotides Nucleic Acids
22
801-804
2003
Mycobacterium tuberculosis
Gardberg, A.; Shuvalova, L.; Monnerjahn, C.; Konrad, M.; Lavie, A.
Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases
Structure
11
1265-1277
2003
Equid alphaherpesvirus 4, Herpes simplex virus
Van Daele, I.; Munier-Lehmann, H.; Hendrickx, P.M.; Marchal, G.; Chavarot, P.; Froeyen, M.; Qing, L.; Martins, J.C.; Van Calenbergh, S.
Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase
ChemMedChem
1
1081-1090
2006
Mycobacterium tuberculosis, Mycobacterium tuberculosis variant bovis
Alexandre, J.A.; Roy, B.; Topalis, D.; Pochet, S.; Perigaud, C.; Deville-Bonne, D.
Enantioselectivity of human AMP, dTMP and UMP-CMP kinases
Nucleic Acids Res.
35
4895-4904
2007
Homo sapiens (P23919)
Kotaka, M.; Dhaliwal, B.; Ren, J.; Nichols, C.E.; Angell, R.; Lockyer, M.; Hawkins, A.R.; Stammers, D.K.
Structures of S. aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon substrate binding
Protein Sci.
15
774-784
2006
Staphylococcus aureus
Gasse, C.; Douguet, D.; Huteau, V.; Marchal, G.; Munier-Lehmann, H.; Pochet, S.
Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity
Bioorg. Med. Chem.
16
6075-6085
2008
Homo sapiens, Mycobacterium tuberculosis
Hu, C.M.; Chang, Z.F.
Synthetic lethality by lentiviral short hairpin RNA silencing of thymidylate kinase and doxorubicin in colon cancer cells regardless of the p53 status
Cancer Res.
68
2831-2840
2008
Homo sapiens
Familiar, O.; Munier-Lehmann, H.; Negri, A.; Gago, F.; Douguet, D.; Rigouts, L.; Hernandez, A.I.; Camarasa, M.J.; Perez-Perez, M.J.
Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase
ChemMedChem
3
1083-1093
2008
Homo sapiens, Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis
Collins, C.M.; Olstad, K.; Sterud, E.; Jones, C.S.; Noble, L.R.; Mo, T.A.; Cunningham, C.O.
Isolation of a novel fish thymidylate kinase gene, upregulated in Atlantic salmon (Salmo salar L.) following infection with the monogenean parasite Gyrodactylus salaris
Fish Shellfish Immunol.
23
793-807
2007
Salmo salar
Chen, Y.L.; Lin, D.W.; Chang, Z.F.
Identification of a putative human mitochondrial thymidine monophosphate kinase associated with monocytic/macrophage terminal differentiation
Genes Cells
13
679-689
2008
Homo sapiens
Kandeel, M.; Kitade, Y.
Molecular characterization, heterologous expression and kinetic analysis of recombinant Plasmodium falciparum thymidylate kinase
J. Biochem.
144
245-250
2008
Plasmodium falciparum
Lavie, A.; Su, Y.; Ghassemi, M.; Novak, R.M.; Caffrey, M.; Sekulic, N.; Monnerjahn, C.; Konrad, M.; Cook, J.L.
Restoration of the antiviral activity of 3'-azido-3'-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus by delivery of engineered thymidylate kinase to T cells
J. Gen. Virol.
89
1672-1679
2008
Escherichia coli, Homo sapiens
Van Daele, I.; Munier-Lehmann, H.; Froeyen, M.; Balzarini, J.; Van Calenbergh, S.
Rational design of 5-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth
J. Med. Chem.
50
5281-5292
2007
Homo sapiens, Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis
Sato, T.; Neschadim, A.; Konrad, M.; Fowler, D.H.; Lavie, A.; Medin, J.A.
Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy
Mol. Ther.
15
962-970
2007
Homo sapiens
Byun, Y.; Vogel, S.R.; Phipps, A.J.; Carnrot, C.; Eriksson, S.; Tiwari, R.; Tjarks, W.
Synthesis and Biological Evaluation of Inhibitors of Thymidine Monophosphate Kinase from Bacillus anthracis
Nucleosides Nucleotides Nucleic Acids
27
244-260
2008
Bacillus anthracis
Ronceret, A.; Gadea-Vacas, J.; Guilleminot, J.; Lincker, F.; Delorme, V.; Lahmy, S.; Pelletier, G.; Chaboute, M.E.; Devic, M.
The first zygotic division in Arabidopsis requires de novo transcription of thymidylate kinase
Plant J.
53
776-789
2008
Arabidopsis thaliana (A0NAB2)
Carnrot, C.; Wang, L.; Topalis, D.; Eriksson, S.
Mechanisms of substrate selectivity for Bacillus anthracis thymidylate kinase
Protein Sci.
17
1486-1493
2008
Bacillus anthracis (Q81W11), Bacillus anthracis
Hu, C.M.; Chang, Z.F.
A bioluminescent method for measuring thymidylate kinase activity suitable for high-throughput screening of inhibitor
Anal. Biochem.
398
269-271
2010
Homo sapiens
Chien, C.Y.; Chen, B.R.; Chou, C.K.; Sclafani, R.A.; Su, J.Y.
The yeast Cdc8 exhibits both deoxythymidine monophosphate and diphosphate kinase activities
FEBS Lett.
583
2281-2286
2009
Saccharomyces cerevisiae
Andrade, C.H.; Pasqualoto, K.F.; Ferreira, E.I.; Hopfinger, A.J.
Rational design and 3D-pharmacophore mapping of 5'-thiourea-substituted alpha-thymidine analogues as mycobacterial TMPK inhibitors
J. Chem. Inf. Model.
49
1070-1078
2009
Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis
Kohler, J.J.; Hosseini, S.H.; Cucoranu, I.; Zhelyabovska, O.; Green, E.; Ivey, K.; Abuin, A.; Fields, E.; Hoying, A.; Russ, R.; Santoianni, R.; Raper, C.M.; Yang, Q.; Lavie, A.; Lewis, W.
Transgenic cardiac-targeted overexpression of human thymidylate kinase
Lab. Invest.
90
383-390
2010
Homo sapiens
Kandeel, M.; Kato, A.; Kitamura, Y.; Kitade, Y.
Thymidylate kinase: the lost chemotherapeutic target
Nucleic Acids Symp. Ser.
53
283-284
2009
Plasmodium falciparum, Anaplasma marginale
Meyer, P.; Caillat, C.; Topalis, D.; Balzarini, J.; Deville-Bonne, D.
Structural basis for the specificity of thymidylate kinases from human pathogens: implications for nucleotide analogues activation
Nucleic Acids Symp. Ser.
53
41
2009
unidentified poxvirus
Caillat, C.; Topalis, D.; Agrofoglio, L.A.; Pochet, S.; Balzarini, J.; Deville-Bonne, D.; Meyer, P.
Crystal structure of poxvirus thymidylate kinase: an unexpected dimerization has implications for antiviral therapy
Proc. Natl. Acad. Sci. USA
105
16900-16905
2008
Vaccinia virus (P68693), Vaccinia virus
Wayengera, M.
Theoretical basis for reducing time-lines to the determination of positive Mycobacterium tuberculosis cultures using thymidylate kinase (TMK) assays
Theor. Biol. Med. Model.
6
4-4
2009
Mycobacterium tuberculosis
Leibly, D.J.; Abendroth, J.; Bryan, C.M.; Sankaran, B.; Kelley, A.; Barrett, L.K.; Stewart, L.; Van Voorhis, W.C.
Structure of thymidylate kinase from Ehrlichia chaffeensis
Acta Crystallogr. Sect. F
67
1090-1094
2011
Ehrlichia chaffeensis (Q2GHN3)
Kandeel, M.; Kitade, Y.
The substrate binding preferences of Plasmodium thymidylate kinase
Biol. Pharm. Bull.
34
173-176
2011
Plasmodium falciparum
Van Poecke, S.; Munier-Lehmann, H.; Helynck, O.; Froeyen, M.; Van Calenbergh, S.
Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase
Bioorg. Med. Chem.
19
7603-7611
2011
Mycobacterium tuberculosis
Toti, K.S.; Verbeke, F.; Risseeuw, M.D.; Frecer, V.; Munier-Lehmann, H.; Van Calenbergh, S.
Synthesis and evaluation of 5-modified thymidines and 5-hydroxymethyl-2-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors
Bioorg. Med. Chem.
21
257-268
2013
Mycobacterium tuberculosis
Familiar, O.; Munier-Lehmann, H.; Ainsa, J.A.; Camarasa, M.J.; Perez-Perez, M.J.
Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone
Eur. J. Med. Chem.
45
5910-5918
2010
Mycobacterium tuberculosis
Topalis, D.; Pradere, U.; Roy, V.; Caillat, C.; Azzouzi, A.; Broggi, J.; Snoeck, R.; Andrei, G.; Lin, J.; Eriksson, S.; Alexandre, J.A.; El-Amri, C.; Deville-Bonne, D.; Meyer, P.; Balzarini, J.; Agrofoglio, L.A.
Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates
J. Med. Chem.
54
222-232
2011
Homo sapiens (P23919), Homo sapiens
Martinez-Botella, G.; Breen, J.N.; Duffy, J.E.; Dumas, J.; Geng, B.; Gowers, I.K.; Green, O.M.; Guler, S.; Hentemann, M.F.; Hernandez-Juan, F.A.; Joseph-McCarthy, D.; Kawatkar, S.; Larsen, N.A.; Lazari, O.; Loch, J.T.; Macritchie, J.A.; McKenzie, A.R.; Newman, J.V.; Olivier, N.B.; Otterson, L.G.; Owens, A.P.
Discovery of selective and potent inhibitors of gram-positive bacterial thymidylate kinase (TMK)
J. Med. Chem.
55
10010-10021
2012
Streptococcus pneumoniae, Staphylococcus aureus
Choi, J.Y.; Plummer, M.S.; Starr, J.; Desbonnet, C.R.; Soutter, H.; Chang, J.; Miller, J.R.; Dillman, K.; Miller, A.A.; Roush, W.R.
Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation
J. Med. Chem.
55
852-870
2012
Pseudomonas aeruginosa (Q9HZN8)
Kumar, M.; Sharma, S.; Srinivasan, A.; Singh, T.P.; Kaur, P.
Structure-based in-silico rational design of a selective peptide inhibitor for thymidine monophosphate kinase of Mycobacterium tuberculosis
J. Mol. Model.
17
1173-1182
2011
Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis
Kato, A.; Yasuda, Y.; Kitamura, Y.; Kandeel, M.; Kitade, Y.
Carbocyclic thymidine derivatives efficiently inhibit Plasmodium falciparum thymidylate kinase (PfTMK)
Parasitol. Int.
61
501-503
2012
Plasmodium falciparum
Guevara-Hernandez, E.; Garcia-Orozco, K.D.; Sotelo-Mundo, R.R.
Biochemical characterization of thymidine monophosphate kinase from white spot syndrome virus: a functional domain from the viral ORF454
Protein Pept. Lett.
19
1220-1224
2012
white spot syndrome virus
Chaudhary, S.K.; Jeyakanthan, J.; Sekar, K.
Cloning, expression, purification, crystallization and preliminary X-ray crystallographic study of thymidylate kinase (TTHA1607) from Thermus thermophilus HB8
Acta Crystallogr. Sect. F
69
118-121
2013
Thermus thermophilus (Q5SHX3), Thermus thermophilus HB8 / ATCC 27634 / DSM 579 (Q5SHX3)
Doharey, P.K.; Suthar, M.K.; Verma, A.; Kumar, V.; Yadav, S.; Balaramnavar, V.M.; Rathaur, S.; Saxena, A.K.; Siddiqi, M.I.; Saxena, J.K.
Molecular cloning and characterization of Brugia malayi thymidylate kinase
Acta Trop.
133
83-92
2014
Wolbachia endosymbiont of Brugia malayi (Q5GTD5), Wolbachia endosymbiont of Brugia malayi TRS (Q5GTD5)
Singh, V.K.; Doharey, P.K.; Kumar, V.; Saxena, J.K.; Siddiqi, M.I.; Rathaur, S.; Narender, T.
Synthesis, molecular docking and Brugia malayi thymidylate kinase (BmTMK) enzyme inhibition study of novel derivatives of [6]-shogaol
Eur. J. Med. Chem.
93
74-82
2015
Wolbachia endosymbiont of Brugia malayi (Q5GTD5), Wolbachia endosymbiont of Brugia malayi TRS (Q5GTD5)
Doharey, P.K.; Singh, S.K.; Verma, P.; Verma, A.; Rathaur, S.; Saxena, J.K.
Insights into the structure-function relationship of Brugia malayi thymidylate kinase (BmTMK)
Int. J. Biol. Macromol.
88
565-571
2016
Wolbachia endosymbiont of Brugia malayi (Q5GTD5), Wolbachia endosymbiont of Brugia malayi TRS (Q5GTD5)
Guevara-Hernandez, E.; Arvizu-Flores, A.A.; Lugo-Sanchez, M.E.; Velazquez-Contreras, E.F.; Castillo-Yanez, F.J.; Brieba, L.G.; Sotelo-Mundo, R.R.
A novel viral thymidylate kinase with dual kinase activity
J. Bioenerg. Biomembr.
47
431-440
2015
white spot syndrome virus
Kawatkar, S.P.; Keating, T.A.; Olivier, N.B.; Breen, J.N.; Green, O.M.; Guler, S.Y.; Hentemann, M.F.; Loch, J.T.; McKenzie, A.R.; Newman, J.V.; Otterson, L.G.; Martinez-Botella, G.
Antibacterial inhibitors of Gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region
J. Med. Chem.
57
4584-4597
2014
Staphylococcus aureus
Naik, M.; Raichurkar, A.; Bandodkar, B.S.; Varun, B.V.; Bhat, S.; Kalkhambkar, R.; Murugan, K.; Menon, R.; Bhat, J.; Paul, B.; Iyer, H.; Hussein, S.; Tucker, J.A.; Vogtherr, M.; Embrey, K.J.; McMiken, H.; Prasad, S.; Gill, A.; Ugarkar, B.G.; Venkatraman, J.; Read, J.; Panda, M.
Structure guided lead generation for M. tuberculosis thymidylate kinase (Mtb TMK): discovery of 3-cyanopyridone and 1,6-naphthyridin-2-one as potent inhibitors
J. Med. Chem.
58
753-766
2015
Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis H37Rv (P9WKE1)
Noguchi, Y.; Yasuda, Y.; Tashiro, M.; Kataoka, T.; Kitamura, Y.; Kandeel, M.; Kitade, Y.
Synthesis of carbocyclic pyrimidine nucleosides and their inhibitory activities against Plasmodium falciparum thymidylate kinase
Parasitol. Int.
62
368-371
2013
Plasmodium falciparum
Sato, T.; Neschadim, A.; Lavie, A.; Yanagisawa, T.; Medin, J.A.
The engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis offers efficient bystander cell killing for suicide gene therapy of cancer
PLoS ONE
8
e78711
2013
Homo sapiens
Keita, M.; Kumar, A.; Dali, B.; Megnassan, E.; Siddiqi, M.; Frecer, V.; Miertus, S.
Quantitative structure-activity relationships and design of thymine-like inhibitors of thymidine monophosphate kinase of Mycobacterium tuberculosis with favourable pharmacokinetic profiles
RSC Adv.
4
55853-55866
2014
Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis H37Rv (P9WKE1)
-
Fucci, I.J.; Sinha, K.; Rule, G.S.
Stabilization of active site dynamics leads to increased activity with 3-azido-3-deoxythymidine monophosphate for F105Y mutant human thymidylate kinase
ACS Omega
5
2355-2367
2020
Homo sapiens (P23919)
Chaudhary, S.K.; Jeyakanthan, J.; Sekar, K.
Structural and functional roles of dynamically correlated residues in thymidylate kinase
Acta Crystallogr. Sect. D
74
341-354
2018
Thermus thermophilus (Q5SHX3), Thermus thermophilus ATCC 27634 (Q5SHX3)
Sinha, K.; Rule, G.S.
The structure of thymidylate kinase from Candida albicans reveals a unique structural element
Biochemistry
56
4360-4370
2017
Candida albicans (Q59TV7), Candida albicans ATCC MYA-2876 (Q59TV7)
Chen, M.D.; Sinha, K.; Rule, G.S.; Ly, D.H.
Interaction of alpha-thymidine inhibitors with thymidylate kinase from Plasmodium falciparum
Biochemistry
57
2868-2875
2018
Plasmodium falciparum (Q8I4S1), Plasmodium falciparum, Plasmodium falciparum isolate 3D7 (Q8I4S1)
Chen, M.D.; Fucci, I.J.; Sinha, K.; Rule, G.S.
dGMP binding to thymidylate kinase from Plasmodium falciparum shows half-site binding and induces protein dynamics at the dimer interface
Biochemistry
59
694-703
2020
Plasmodium falciparum
Biswas, A.; Jasti, S.; Jeyakanthan, J.; Sekar, K.
Role of sequence evolution and conformational dynamics in the substrate specificity and oligomerization mode of thymidylate kinases
J. Biomol. Struct. Dyn.
35
2136-2154
2017
Sulfurisphaera tokodaii (Q970Q8), Sulfurisphaera tokodaii DSM 16993 (Q970Q8)
Song, L.; Merceron, R.; Gracia, B.; Quintana, A.L.; Risseeuw, M.D.P.; Hulpia, F.; Cos, P.; Ainsa, J.A.; Munier-Lehmann, H.; Savvides, S.N.; Van Calenbergh, S.
Structure guided lead generation toward nonchiral M. tuberculosis thymidylate kinase inhibitors
J. Med. Chem.
61
2753-2775
2018
Mycobacterium tuberculosis (A5U7S1), Mycobacterium tuberculosis (P9WKE1), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKE1)
Biswas, A.; Shukla, A.; Vijayan, R.S.K.; Jeyakanthan, J.; Sekar, K.
Crystal structures of an archaeal thymidylate kinase from Sulfolobus tokodaii provide insights into the role of a conserved active site arginine residue
J. Struct. Biol.
197
236-249
2017
Sulfurisphaera tokodaii (Q970Q8), Sulfurisphaera tokodaii DSM 16993 (Q970Q8)
Frisk, J.H.; Eriksson, S.; Pejler, G.; Wang, L.
Identification of a novel thymidylate kinase activity
Nucleosides Nucleotides Nucleic Acids
39
1359-1368
2020
Homo sapiens, Homo sapiens (P23919)
Najera-Martinez, M.; Pedroza-Garcia, J.; Suzuri-Hernandez, L.; Mazubert, C.; Drouin-Wahbi, J.; Vazquez-Ramos, J.; Raynaud, C.; Plasencia, J.
Maize thymidine kinase activity is present throughout plant development and its heterologous expression confers tolerance to an organellar DNA-damaging agent
Plants (Basel)
9
1-14
2020
Zea mays (B0R217)
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