2.7.6.1: ribose-phosphate diphosphokinase

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For detailed information about ribose-phosphate diphosphokinase, go to the full flat file.

Reaction

Synonyms

5-phospho-alpha D-ribosyl 1-diphosphate synthase, 5-phosphoribose pyrophosphorylase, 5-phosphoribosyl-1-alpha-diphosphate synthase, 5-phosphoribosyl-1-pyrophosphate synthetase, 5-phosphoribosyl-alpha-1-pyrophosphate synthetase, AN6711.2, ATP: D-ribose-5-phosphate pyrophosphotransferase, ATP:D-ribose-5-phosphate pyrophosphotransferase, bsPRS, Pcal_1127, phosphoribosyl diphosphate synthase, phosphoribosyl pyrophosphate synthase 1 (PRS-1), phosphoribosyl pyrophosphate synthase enzyme, phosphoribosyl pyrophosphate synthetase, phosphoribosyl-1-pyrophosphate synthetase, phosphoribosyl-diphosphate synthetase, phosphoribosylpyrophosphate synthase, phosphoribosylpyrophosphate synthetase, phosphoribosylpyrophosphate synthetase 1, phosphoribosylpyrophosphate synthetase subunit 1, PP-ribose P synthetase, PPRibP synthetase, PRibPP synthase, PRPP synthase, PRPP synthetase, PRPPase, PRPPS, PRPPS1, PRPPS2, PRPS1, Prps1a, Prps1b, PRS, PRS-I, PRS1, Prs4, PrsA, PrsB, PrsC, pyrophosphokinase, ribose phosphate, pyrophosphoribosylphosphate synthetase, ribophosphate pyrophosphokinase, ribose-5-phosphate pyrophosphokinase, ribose-phosphate pyrophosphokinase, ribose-phosphate pyrophosphokinase 1, RPPK, SSO1045, TT_C1184, TT_C1274

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.6 Diphosphotransferases

                2.7.6.1 ribose-phosphate diphosphokinase

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Results	in table
57	Activating Compound
43931	AA Sequence
3	Application
1	CAS Registry Number
34	Cloned(Commentary)
7	Cofactor
19	Crystallization (Commentary)
506	Disease/ Diagnostics
2	Expression
19	General Information
12	General Stability
21	IC50 Value
238	Inhibitors
13	kcat/KM [mM/s]
51	Ki Value [mM]
171	KM Value [mM]
13	Localization
114	Metals/Ions
74	Molecular Weight [Da]
47	Natural Substrates/ Products (Substrates)
295	Organism
8	Pathway
89	PDB ID
28	pH Optimum
8	pH Range
6	pH Stability
12	pI Value
38	Protein Variants
34	Purification (Commentary)
23	Reaction
1	Reaction Type
100	Reference
51	Source Tissue
60	Specific Activity [micromol/min/mg]
12	Storage Stability
220	Substrates and Products (Substrate)
57	Subunits
112	Synonyms
1	Systematic Name
27	Temperature Optimum [°C]
1	Temperature Range [°C]
14	Temperature Stability [°C]
17	Turnover Number [1/s]

Cofactor

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Cofactor on EC 2.7.6.1 - ribose-phosphate diphosphokinase

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COFACTOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

ATP

3 entries

CTP

Pyrobaculum calidifontis

A3MV85

can partially substitute for ATP

738194

dATP

Pyrobaculum calidifontis

A3MV85

best cofactor, Pcal_1127 exhibits slightly higher activity with dATP compared to ATP as diphosphate donor

738194

GTP

Pyrobaculum calidifontis

A3MV85

can partially substitute for ATP

738194

UTP

Pyrobaculum calidifontis

A3MV85

low activity

738194

ATP

Escherichia coli

P0A717

-

738085

ATP

Homo sapiens

P60891

the AMP moiety of ATP binds at the ATP-binding site, structure, overview. A Cd2+ ion binds at the active site and in a position to interact with the beta- and gamma -phosphates of ATP

671884

ATP

Pyrobaculum calidifontis

A3MV85

best cofactor, Pcal_1127 exhibits slightly higher activity with dATP compared to ATP as diphosphate donor

738194