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2.7.6.1: ribose-phosphate diphosphokinase

This is an abbreviated version!
For detailed information about ribose-phosphate diphosphokinase, go to the full flat file.

Word Map on EC 2.7.6.1

Reaction

ATP
+
D-ribose 5-phosphate
=
AMP
 +
5-phospho-alpha-D-ribose 1-diphosphate

Synonyms

5-phospho-alpha D-ribosyl 1-diphosphate synthase, 5-phosphoribose pyrophosphorylase, 5-phosphoribosyl-1-alpha-diphosphate synthase, 5-phosphoribosyl-1-pyrophosphate synthetase, 5-phosphoribosyl-alpha-1-pyrophosphate synthetase, AN6711.2, ATP: D-ribose-5-phosphate pyrophosphotransferase, ATP:D-ribose-5-phosphate pyrophosphotransferase, bsPRS, Pcal_1127, phosphoribosyl diphosphate synthase, phosphoribosyl pyrophosphate synthase 1 (PRS-1), phosphoribosyl pyrophosphate synthase enzyme, phosphoribosyl pyrophosphate synthetase, phosphoribosyl-1-pyrophosphate synthetase, phosphoribosyl-diphosphate synthetase, phosphoribosylpyrophosphate synthase, phosphoribosylpyrophosphate synthetase, phosphoribosylpyrophosphate synthetase 1, phosphoribosylpyrophosphate synthetase subunit 1, PP-ribose P synthetase, PPRibP synthetase, PRibPP synthase, PRPP synthase, PRPP synthetase, PRPPase, PRPPS, PRPPS1, PRPPS2, PRPS1, Prps1a, Prps1b, PRS, PRS-I, PRS1, Prs4, PrsA, PrsB, PrsC, pyrophosphokinase, ribose phosphate, pyrophosphoribosylphosphate synthetase, ribophosphate pyrophosphokinase, ribose-5-phosphate pyrophosphokinase, ribose-phosphate pyrophosphokinase, ribose-phosphate pyrophosphokinase 1, RPPK, SSO1045, TT_C1184, TT_C1274

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.6 Diphosphotransferases
                2.7.6.1 ribose-phosphate diphosphokinase

Specific Activity

Specific Activity on EC 2.7.6.1 - ribose-phosphate diphosphokinase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.001
-
mitochondria preparation
0.004
-
chloroplast preparation
0.01
-
wild-type strain
0.011 - 0.012
-
mutant strain GPD-PRS2,4, engineered gene AGR371C
0.014
-
isoenzyme PRS1, without phosphate and ADP
0.016
-
mutant enzyme G209V, at pH 7.5 and 37°C
0.017 - 0.018
-
mutant strain GPD-PRS3, engineered gene AGL080C
0.018
-
isoenzyme PRS2, in the presence of phosphate 50 mM, and ADP 1 mM
0.025
-
isoenzyme PRS2, without phosphate and ADP
0.027
-
mutant enzyme D224A, at pH 7.5 and 37°C
0.028
-
crude extract, in 50 mM Tris-HCl pH 8.0, at 25°C
0.032
-
mutant enzyme G50D, at pH 7.5 and 37°C
0.041
-
mutant enzyme E306K, at pH 7.5 and 37°C
0.054
-
mutant enzyme A181D, at pH 7.5 and 37°C
0.072
-
isoenzyme PRS4, in the presence of phosphate 50 mM, and ADP 1 mM
0.074
-
isoenzyme PRS1, in the presence of phosphate 50 mM, and ADP 1 mM
0.08
-
isoenzyme PRS4, in the presence of phosphate 50 mM, without ADP
0.089
-
isoenzyme PRS4, without phosphate and ADP
0.094
-
wild type enzyme, at pH 7.5 and 37°C
0.099
-
isoenzyme PRS4, in the presence of ADP 1 mM, without phosphate
0.14
-
isoenzyme PRS2, in the presence of phosphate 50 mM, without ADP
0.191
-
isoenzyme PRS1, in the presence of phosphate 50 mM, without ADP
0.88
-
isoenzyme PRS3, in the presence of phosphate 50 mM, and ADP 1 mM
0.884
-
isoenzyme PRS3, in the presence of ADP 1 mM, without phosphate
1.06
-
isoenzyme PRS3, in the presence of phosphate 50 mM, without ADP
1.16
-
after 41.4fold purification, in 50 mM Tris-HCl pH 8.0, at 25°C
1.26
-
isoenzyme PRS3, without phosphate and ADP
10.4
-
liver enzyme complex with PAP39 and PRS at a mass ratio of 0.34
16.2
-
native enzyme from liver, pH 8.6
190
-
30fold to 50fold more activity in the cloned enzyme than in the enzyme from the wild-type cells
2.45
-
native enzyme from liver, reverse reaction, pH 8.6
20.5 - 21.2
-
values from lymphoblasts extracts from normal and PRS catalytic superactivity affected patients
22.2 - 29.9
-
values from fibroblast extracts from normal and PRS catalytic superactivity affected patients
25
-
isoenzyme PRSI
25.7
-
isoenzyme PRSI
3.59
-
native enzyme from liver, reverse reaction, pH 7.4
3.65
-
wild type enzyme
34.5
-
isoenzyme PRSII
35.7
-
isoenzyme PRSII
39.1
-
isoenzyme rPRSI, pH 8.6
4.24
-
isoenzyme rPRSII, reverse reaction, pH 8.6
4.5
-
isoenzyme rPRSI, reverse reaction, pH 8.6
480
pH 10.5, 55°C, purified recombinant enzyme
7.48
-
isoenzyme rPRSI, reverse reaction, pH 7.4
8.04
-
isoenzyme rPRSII, reverse reaction, pH 7.4
8.17
-
mutant enzyme
8.3
-
isoenzyme rPRSII, pH 8.6
additional information