2.7.6.2: thiamine diphosphokinase
This is an abbreviated version!
For detailed information about thiamine diphosphokinase, go to the full flat file.
Word Map on EC 2.7.6.2
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2.7.6.2
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pyrophosphate
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dihydropteroate
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pyrophosphorylated
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tdp
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ribosephosphate
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hydroxymethyldihydropterin
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pyrithiamine
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6-hydroxymethyl-7,8-dihydropterin
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dihydroneopterin
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thiamine-responsive
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oxythiamine
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megaloblastic
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medicine
- 2.7.6.2
- pyrophosphate
- dihydropteroate
-
pyrophosphorylated
- tdp
-
ribosephosphate
-
hydroxymethyldihydropterin
- pyrithiamine
- 6-hydroxymethyl-7,8-dihydropterin
- dihydroneopterin
-
thiamine-responsive
- oxythiamine
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megaloblastic
- medicine
Reaction
Synonyms
At1g02880 (AtTPK1), At2g44750 (AtTPK2), ATP:thiamin pyrophosphotransferase, CA1462, hTPK1, Plasmodium falciparum thiamine pyrophosphokinase, pyrophosphokinase, pyrophosphokinase, thiamin, TDPK, thiamin kinase, thiamin pyrophosphokinase, thiamin pyrophosphotransferase, thiamin:ATP pyrophosphotransferase, thiamine diphosphokinase, thiamine kinase, thiamine pyrophokinase, thiamine pyrophosphokinase, thiaminokinase, TPK, Tpk1, TPTase, YcfN
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medicine
additional information
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Administration of oxythiamine to animals produces primarily metabolic aberrations such as lethargy and anorexia while the administration of pyrithiamine to animals produces neurological problems similar to Wernicke-Korsakoff Syndrome.
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Malaria is a devastating and quite often deadly parasitic disease, resulting in significant public health problems in the tropics. The inevitable emergence of drug-resistant forms requires the continuous discovery and development of new antimalarials. These drugs should only target the parasite, with only harmless or no effects on the human host. Thus, ideal drug targets would be peculiarities in the parasite metabolism, such as vitamin B1 and B6 biosyntheses that are absent in its host.
medicine
TPK1 is post-transcriptionally upregulated in cancer cells following hypoxic exposure. TPK1 expression is also adaptively upregulated following alterations of redox status by chemotherapeutic and antioxidant treatments. Despite upregulation by hypoxia, intracellular TPP levels are reduced. This loss was reversed by treatment with cell-permeable antioxidants and corresponds with reduced ROS production and enhanced cellular proliferation during supplemental thiamine conditions. siRNA-mediated knockdown of TPK1 directly enhances basal ROS levels and reduces tumor cell proliferation