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2.7.6.2: thiamine diphosphokinase

This is an abbreviated version!
For detailed information about thiamine diphosphokinase, go to the full flat file.

Word Map on EC 2.7.6.2

Reaction

ATP
+
thiamine
=
AMP
 +
thiamine diphosphate

Synonyms

At1g02880 (AtTPK1), At2g44750 (AtTPK2), ATP:thiamin pyrophosphotransferase, CA1462, hTPK1, Plasmodium falciparum thiamine pyrophosphokinase, pyrophosphokinase, pyrophosphokinase, thiamin, TDPK, thiamin kinase, thiamin pyrophosphokinase, thiamin pyrophosphotransferase, thiamin:ATP pyrophosphotransferase, thiamine diphosphokinase, thiamine kinase, thiamine pyrophokinase, thiamine pyrophosphokinase, thiaminokinase, TPK, Tpk1, TPTase, YcfN

ECTree

     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.6 Diphosphotransferases
                2.7.6.2 thiamine diphosphokinase

Engineering

Engineering on EC 2.7.6.2 - thiamine diphosphokinase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D100N
mutation reduces turnover-number markedly
D133N
mutation causes a selective decrease in the ratio of turnover-number to Km-value for thiamine
D222H
naturally occurring homozygous TPK1 mutation in a patient with enzyme deficiency suffering neurological disorder
D71N
mutation reduces turnover-number markedly
D73N
mutation reduces turnover-number markedly
Q96E
mutation causes an 2.5fold increase in the ratio of turnover-number to Km-value for thiamine compared to the wild-type
R131G
mutation decreases the ratio of turnover-number to Km-value for ATP
S160L
naturally occurring homozygous TPK1 mutation in a patient with enzyme deficiency suffering neurological disorder. Early thiamine supplementation prevents encephalopathic episodes and improved developmental progression of Patient 1, emphasizing the importance of early diagnosis and treatment of TPK deficiency. The p.Ser160Leu mutation is predicted to interferewith TPK dimerization, which may be another mechanism for the disease
S74A
mutation causes a 1.4fold increase in turnover number, the Km-value for ATP is 2fold that of the wild-type enzyme
T99A
mutation decreases the ratio of turnover-number to Km-value for ATP
additional information