2.7.6.2: thiamine diphosphokinase

This is an abbreviated version!
For detailed information about thiamine diphosphokinase, go to the full flat file.

Word Map on EC 2.7.6.2

2.7.6.2

pyrophosphate

dihydropteroate

pyrophosphorylated

tdp

ribosephosphate

hydroxymethyldihydropterin

pyrithiamine

6-hydroxymethyl-7,8-dihydropterin

dihydroneopterin

thiamine-responsive

oxythiamine

megaloblastic

medicine

Reaction

Synonyms

At1g02880 (AtTPK1), At2g44750 (AtTPK2), ATP:thiamin pyrophosphotransferase, CA1462, hTPK1, Plasmodium falciparum thiamine pyrophosphokinase, pyrophosphokinase, pyrophosphokinase, thiamin, TDPK, thiamin kinase, thiamin pyrophosphokinase, thiamin pyrophosphotransferase, thiamin:ATP pyrophosphotransferase, thiamine diphosphokinase, thiamine kinase, thiamine pyrophokinase, thiamine pyrophosphokinase, thiaminokinase, TPK, Tpk1, TPTase, YcfN

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.6 Diphosphotransferases

2.7.6.2 thiamine diphosphokinase

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Results	in table
1	Activating Compound
14443	AA Sequence
3	Application
1	CAS Registry Number
9	Cloned(Commentary)
5	Cofactor
5	Crystallization (Commentary)
87	Disease/ Diagnostics
1	Expression
3	General Information
1	General Stability
34	Inhibitors
3	Ki Value [mM]
38	KM Value [mM]
8	Localization
22	Metals/Ions
11	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
37	Organism
8	Pathway
14	PDB ID
10	pH Optimum
3	pH Range
2	pI Value
12	Protein Variants
13	Purification (Commentary)
3	Reaction
1	Reaction Type
35	Reference
50	Source Tissue
12	Specific Activity [micromol/min/mg]
50	Substrates and Products (Substrate)
8	Subunits
48	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
4	Temperature Range [°C]
2	Temperature Stability [°C]
18	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.7.6.2 - thiamine diphosphokinase

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ALT-711

Homo sapiens

low-affinity inhibitor, mixed-mode inhibition with a major role for competitive inhibition

723746

AMP

Glycine max

0.5 mM, 8% inhibition

642753

Butylthiamine

Sus scrofa

competitive with respect to thiamine

642751

Chloroethylthiamine

Paracoccus denitrificans

weak

642749

diphosphate

4 entries

ethylthiamine

Sus scrofa

competitive with respect to thiamine

iodoacetamide

KCN

little effect

Mn2+

Saccharomyces cerevisiae

5 mM

molybdate

little effect

NaF

little effect

NEM

oxythiamine

PCMB

pyrithiamine

thiamine diphosphate

Thiamine monophosphate

Petroselinum crispum

642745, 642746