2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

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For detailed information about 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase, go to the full flat file.

Reaction

Synonyms

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase, 6-hydroxy-7,8-dihydropterin pyrophosphokinase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK), 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydroxypterin pyrophosphokinase/7,8-dihydropteroate synthase, 6-hydroxymethylpterin pyrophosphokinase, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase, 7,8-dihydropteroate-synthesizing enzyme, 7,8-dihydroxymethylpterin-pyrophosphokinase, ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-pyrophosphotransferase, cytHPPK/DHPS, dihydropterin pyrophosphokinase, FOLK, FtHPPK-DHPS, H2-pteridine-CH2-OH pyrophosphokinase, H2-pteridine-CH2OH pyrophosphokinase, HPPK, HPPK-DHPS, HPPK/DHPS, HPPK/dihydropteroate synthase, hydroxymethyl-7,8-dihydropterin pyrophosphokinase/7,8-dihydropteroate synthase, hydroxymethyldihydropteridine pyrophosphokinase, hydroxymethyldihydropterin diphosphokinase/dihydropteroate synthase, hydroxymethyldihydropterin pyrophosphokinase (HPPK), hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, mitHPPK/DHPS, More, PPPK, PPPK-DHPS, PVX_123230, pyrophosphokinase, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.6 Diphosphotransferases

                2.7.6.3 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

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Results	in table
1	Activating Compound
42934	AA Sequence
4	Application
1	CAS Registry Number
17	Cloned(Commentary)
10	Cofactor
22	Crystallization (Commentary)
13	General Information
6	IC50 Value
164	Inhibitors
71	Ki Value [mM]
20	KM Value [mM]
5	Localization
25	Metals/Ions
13	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
52	Organism
10	Pathway
92	PDB ID
12	pH Optimum
2	pH Range
3	pI Value
32	Protein Variants
19	Purification (Commentary)
5	Reaction
1	Reaction Type
51	Reference
2	Source Tissue
4	Specific Activity [micromol/min/mg]
2	Storage Stability
54	Substrates and Products (Substrate)
13	Subunits
88	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
2	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 2.7.6.3 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

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MOLECULAR WEIGHT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

150000

Escherichia coli

-

gel filtration

642760

18000

Escherichia coli

P26281

x * 18000, SDS-PAGE

723713

18299

Haemophilus influenzae

-

1 * 18299, calculation from nucleotide sequence

642764

190000

Plasmodium chabaudi

-

gel filtration

639668, 639670

20000

Haemophilus influenzae

-

gel filtration, equilibrium sedimentation, quasi-elastic light scattering

642764

25000

Escherichia coli

-

gel filtration

639671

330000

Plasmodium falciparum

-

gel filtration

662800

50509

Francisella tularensis

A0A6B2JKF9

1 * 50509, the bifunctional enzyme HPPK-DHPS exists mainly as a monomer in solution, calculated from amino acid sequence

723522

53000

Francisella tularensis

A0A6B2JKF9

1 * 53000, the bifunctional enzyme HPPK-DHPS exists mainly as a monomer in solution, sedimentation velocity and equilibrium analysis

723522

54053

Arabidopsis thaliana

Q1ENB6

x * 54053, sequence calculation

674784

69000

Pneumocystis carinii

-

calculation from multifunctional folic acid synthesis fas gene that encodes dihydroneopterin aldolase, hydroxymethyldihydropterin pyrophosphokinase and dihydropteroate synthase

5108

83000

Plasmodium falciparum

-

4 * 83000, SDS-PAGE

662800