2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

This is an abbreviated version!
For detailed information about 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase, go to the full flat file.

Word Map on EC 2.7.6.3

2.7.6.3

pyrophosphorylation

pyrophosphate

pterins

folic

dihydrofolate

bisubstrate

sulfa

dihydroneopterin

ampcpp

tetrahydrofolate

induced-fit

drug development

medicine

Reaction

6-hydroxymethyl-7,8-dihydropterin diphosphate

Synonyms

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase, 6-hydroxy-7,8-dihydropterin pyrophosphokinase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK), 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydroxypterin pyrophosphokinase/7,8-dihydropteroate synthase, 6-hydroxymethylpterin pyrophosphokinase, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase, 7,8-dihydropteroate-synthesizing enzyme, 7,8-dihydroxymethylpterin-pyrophosphokinase, ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-pyrophosphotransferase, cytHPPK/DHPS, dihydropterin pyrophosphokinase, FOLK, FtHPPK-DHPS, H2-pteridine-CH2-OH pyrophosphokinase, H2-pteridine-CH2OH pyrophosphokinase, HPPK, HPPK-DHPS, HPPK/DHPS, HPPK/dihydropteroate synthase, hydroxymethyl-7,8-dihydropterin pyrophosphokinase/7,8-dihydropteroate synthase, hydroxymethyldihydropteridine pyrophosphokinase, hydroxymethyldihydropterin diphosphokinase/dihydropteroate synthase, hydroxymethyldihydropterin pyrophosphokinase (HPPK), hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, mitHPPK/DHPS, More, PPPK, PPPK-DHPS, PVX_123230, pyrophosphokinase, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.6 Diphosphotransferases

2.7.6.3 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

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Results	in table
1	Activating Compound
42934	AA Sequence
4	Application
1	CAS Registry Number
17	Cloned(Commentary)
10	Cofactor
22	Crystallization (Commentary)
13	General Information
6	IC50 Value
164	Inhibitors
71	Ki Value [mM]
20	KM Value [mM]
5	Localization
25	Metals/Ions
13	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
52	Organism
10	Pathway
92	PDB ID
12	pH Optimum
2	pH Range
3	pI Value
32	Protein Variants
19	Purification (Commentary)
5	Reaction
1	Reaction Type
51	Reference
2	Source Tissue
4	Specific Activity [micromol/min/mg]
2	Storage Stability
54	Substrates and Products (Substrate)
13	Subunits
88	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
2	Turnover Number [1/s]

Organism

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Organism on EC 2.7.6.3 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

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Francisella tularensis

2 entries

Francisella tularensis LVS

723522

A0A6B2JKF9

UniProt

Francisella tularensis SCHU S4

gene folK, single copy gene

738210

Q5NGA7

UniProt

Haemophilus influenzae

Brookhaven Protein Data Bank: 1cbk

Plasmodium falciparum

4 entries

Plasmodium vivax

2 entries

Plasmodium vivax Salvador 1

cf. EC 2.5.1.15

759490

A5JZS1

UniProt

Plasmodium vivax Salvador I

bifunctional 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) and dihydropteroate synthase, cf. EC 2.5.1.15

UniProt

Saccharomyces cerevisiae

2 entries

Staphylococcus aureus

721193, 738835, 738849, 761534

Streptococcus pneumoniae

Q7CKD7

UniProt