2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

This is an abbreviated version!
For detailed information about 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase, go to the full flat file.

Word Map on EC 2.7.6.3

2.7.6.3

pyrophosphorylation

pyrophosphate

pterins

folic

dihydrofolate

bisubstrate

sulfa

dihydroneopterin

ampcpp

tetrahydrofolate

induced-fit

drug development

medicine

Reaction

6-hydroxymethyl-7,8-dihydropterin diphosphate

Synonyms

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase, 6-hydroxy-7,8-dihydropterin pyrophosphokinase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK), 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydroxypterin pyrophosphokinase/7,8-dihydropteroate synthase, 6-hydroxymethylpterin pyrophosphokinase, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase, 7,8-dihydropteroate-synthesizing enzyme, 7,8-dihydroxymethylpterin-pyrophosphokinase, ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-pyrophosphotransferase, cytHPPK/DHPS, dihydropterin pyrophosphokinase, FOLK, FtHPPK-DHPS, H2-pteridine-CH2-OH pyrophosphokinase, H2-pteridine-CH2OH pyrophosphokinase, HPPK, HPPK-DHPS, HPPK/DHPS, HPPK/dihydropteroate synthase, hydroxymethyl-7,8-dihydropterin pyrophosphokinase/7,8-dihydropteroate synthase, hydroxymethyldihydropteridine pyrophosphokinase, hydroxymethyldihydropterin diphosphokinase/dihydropteroate synthase, hydroxymethyldihydropterin pyrophosphokinase (HPPK), hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, mitHPPK/DHPS, More, PPPK, PPPK-DHPS, PVX_123230, pyrophosphokinase, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.6 Diphosphotransferases

2.7.6.3 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

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Results	in table
1	Activating Compound
42934	AA Sequence
4	Application
1	CAS Registry Number
17	Cloned(Commentary)
10	Cofactor
22	Crystallization (Commentary)
13	General Information
6	IC50 Value
164	Inhibitors
71	Ki Value [mM]
20	KM Value [mM]
5	Localization
25	Metals/Ions
13	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
52	Organism
10	Pathway
92	PDB ID
12	pH Optimum
2	pH Range
3	pI Value
32	Protein Variants
19	Purification (Commentary)
5	Reaction
1	Reaction Type
51	Reference
2	Source Tissue
4	Specific Activity [micromol/min/mg]
2	Storage Stability
54	Substrates and Products (Substrate)
13	Subunits
88	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
2	Turnover Number [1/s]

Synonyms

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Synonyms on EC 2.7.6.3 - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

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2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

2 entries

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

2 entries

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase

2 entries

6-hydroxy-7,8-dihydropterin pyrophosphokinase

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase

8 entries

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK)

Arabidopsis thaliana

674784

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase

2 entries

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase/dihydropteroate synthase

Saccharomyces cerevisiae

bifunctional enzyme

662648

6-hydroxymethyl-7,8-dihydroxypterin pyrophosphokinase/7,8-dihydropteroate synthase

Pisum sativum

bifunctional protein involved in tetrahydrofolate synthesis

639684

6-hydroxymethylpterin pyrophosphokinase

Saccharomyces cerevisiae

P53848

671307

7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase

7,8-dihydropteroate-synthesizing enzyme

Plasmodium chabaudi

it is not possible to distinguish, whether the enzyme exists as an enzyme complex of 6-hydroxymethyl-7,8-dihydroxypterin pyrophosphokinase and 7,8-dihydropteroate synthase or whether both reactions are catalyzed by a single enzyme

639668, 639670

7,8-dihydroxymethylpterin-pyrophosphokinase

ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-pyrophosphotransferase

cytHPPK/DHPS

Arabidopsis thaliana

Q1ENB6

674784

dihydropterin pyrophosphokinase

Plasmodium falciparum

FOLK

FtHPPK-DHPS

H2-pteridine-CH2-OH pyrophosphokinase

H2-pteridine-CH2OH pyrophosphokinase

HPPK

11 entries

HPPK-DHPS

4 entries

HPPK/DHPS

2 entries

HPPK/dihydropteroate synthase

Plasmodium falciparum

HPPK part of the bifunctional protein can function by itself but a larger part of the polypeptide is needed to ensure full functionality

662804

hydroxymethyl-7,8-dihydropterin pyrophosphokinase/7,8-dihydropteroate synthase

Arabidopsis thaliana

Q1ENB6

674784

hydroxymethyldihydropteridine pyrophosphokinase

hydroxymethyldihydropterin diphosphokinase/dihydropteroate synthase

Plasmodium falciparum

HPPK part of the bifunctional protein can function by itself but a larger part of the polypeptide is needed to ensure full functionality

662804

hydroxymethyldihydropterin pyrophosphokinase (HPPK)

Arabidopsis thaliana

674784

hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase

Plasmodium falciparum

bifunctional enzyme

mitHPPK/DHPS

PPPK

PPPK-DHPS

Plasmodium falciparum

cf. EC 2.5.1.5

PVX_123230

pyrophosphokinase, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine

additional information

Pneumocystis carinii

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase domain of the multifunctional folic acid synthesis enzyme

642760