2.7.6.5: GTP diphosphokinase
This is an abbreviated version!
For detailed information about GTP diphosphokinase, go to the full flat file.
Word Map on EC 2.7.6.5
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2.7.6.5
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pppgpp
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rela
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rsh
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tetraphosphate
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a-site
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actinorhodine
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mupirocin
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ribosome-dependent
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sass
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3'-diphosphate
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rela-spot
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thiostrepton
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pyrophosphorylate
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rela-dependent
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drug development
- 2.7.6.5
- pppgpp
- rela
- rsh
- tetraphosphate
-
a-site
-
actinorhodine
- mupirocin
-
ribosome-dependent
-
sass
- 3'-diphosphate
-
rela-spot
- thiostrepton
-
pyrophosphorylate
-
rela-dependent
- drug development
Reaction
Synonyms
(p)ppGpp synthase, (p)ppGpp synthetase, (p)ppGpp synthetase I, (p)ppGpp synthetase II, (p)ppGpp synthetase/hydrolase, alarmone synthetase, ATP-GTP 3'-diphosphotransferase, ATP:GTP 3'-pyrophosphotransferase, ATP:GTP pyrophosphoryl transferase, GPSI, GPSII, GTP pyrophosphokinase, guanosine 3',5'-polyphosphate synthase, guanosine 3',5'-polyphosphate synthetase, guanosine 5',3'-polyphosphate synthetase, guanosine pentaphosphate synthetase, ppGpp synthase I, Rel, Rel/Spo protein, RelA, RelMtb, RelMtb protein, RelP, RelSeq, RSH3, SAS 1, SAS 2, SAS1, SF, small alarmone synthase 1, small alarmone synthase 2, small alarmone synthetase 1, stringent factor, YjbM, YwaC
ECTree
2.7.6.5 GTP diphosphokinaseAdvanced search results
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results (Activating Compound
Activating Compound on EC 2.7.6.5 - GTP diphosphokinase
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
dCDP
slightly stimulates synthesis of guanosine 3'-diphosphate 5'-triphosphate, inhibits polynucleotide phosphorylase activities of enzyme
ethanol
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little activity unless activated either by a complex of 70S ribosomes, mRNA and uncharged tRNA or by a solvent like ethanol at approximately 20%
guanosine-5',3'-dibisphosphate
ppGpp, potential allosteric regulator, activates the enzyme with an EC50 of 0.060 mM
tRNA
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uncharged or charged, stimulation, level of stimulation is greater in presence of RNA and poly(U) together than with either RNA alone
mRNA
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little activity unless activated either by a complex of 70S ribosomes, mRNA and uncharged tRNA or by a solvent like ethanol at approximately 20%
mRNA
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synthetic, e.g. poly(U), stimulates, level of stimulation is greater in presence of RNA and poly(U) together than with either RNA alone, no activation by ribosomes
additional information
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little activity unless activated either by a complex of 70S ribosomes, mRNA and uncharged tRNA or by a solvent like ethanol at approximately 20%
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additional information
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addition of template, unacylated tRNA and ribosomes to the activity assay stimulates SF 30fold when using optimal conditions, activity of SF increases threefold in the presence of twice salt-washed tight-couple ribosomes and twofold in the presence of reassociated ribosomes compared to the endogenous activity of the enzyme
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additional information
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ribosome complexes formed with tight binding tRNAVal stimulate enzyme activity at lower concentrations than that required for ribosome complexes formed with the weaker binding tRNAPhe
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additional information
activation of Francisella tularensis RelA by stalled ribosomal complexes formed with ribosomes purified from Escherichia coli MRE600, and significantly weaker activation with ribosomes isolated from Francisella philomiragia
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additional information
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GPS I can be activated by incubation with crude mycelial extract, activation is partially inhibited by the inclusion of trypsin inhibitor in reaction mixture
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