2.7.7.1: nicotinamide-nucleotide adenylyltransferase

This is an abbreviated version!
For detailed information about nicotinamide-nucleotide adenylyltransferase, go to the full flat file.

Word Map on EC 2.7.7.1

2.7.7.1

degeneration

wallerian

neurodegenerative

neuroprotective

amaurosis

leber

nampt

self-destruct

axotomy

riboside

nadase

tiazofurin

axonopathies

pro-degenerative

analysis

drug development

pharmacology

medicine

Reaction

Synonyms

adenosine triphosphate-nicotinamide mononucleotide transadenylase, adenylyltransferase, nicotinamide mononucleotide, Arabidopsis thaliana nicotinate/nicotinamide mononucleotide adenyltransferase, AtNMNAT, ATP:NMN adenylyltransferase, diphosphopyridine nucleotide pyrophosphorylase, Drosophila NMNAT, GlNMNAT, hNMNAT, hNMNAT-1, hNMNAT-2, human nicotinamide mononucleotide adenylyl-transferase, m-nonN-Nmnat1, mononucleotide adenylyltransferase, More, NAD synthase, NAD+ pyrophosphorylase, nadD, NadM-Nudix, NadR, NaMNAT, nicotinamide 5'-mononucleotide adenylyltransferase, nicotinamide 5'-mononucleotide adenylyltransferase-2, nicotinamide 5-mononucleotide adenylyltransferase-2, nicotinamide adenine dinucleotide pyrophosphorylase, nicotinamide mononucleotide adenylyl-transferase, nicotinamide mononucleotide adenylyltransferase, nicotinamide mononucleotide adenylyltransferase 1, nicotinamide mononucleotide adenylyltransferase 2, nicotinamide mononucleotide adenylyltransferase type 1, nicotinamide mononucleotide adenylyltransferase1, nicotinamide mononucleotide adenylyltransferase2, nicotinamide/nicotinate mononucleotide adenylyltransferase, nicotinamide/nicotinic acid mononucleotide adenylyltransferase, nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1, nicotinate/nicotinamide mononucleotide adenyltransferase, NMN adenylyl transferase 1, NMN adenylyltransferase, NMN adenylyltransferase/ADP-ribose pyrophosphatase, NMN AT, NMN-adenylyltransferase, NMN/NaMN adenylyltransferase, NMN/NaMN adenylyltransferase 2, NMN/NaMN adenylyltransferase 3, NMNAT, NMNAT-2, NMNAT1, NMNAT2, NMNAT3, NMNATase, non-nuclear-localized-Nmnat1, PF3D7_1327600, PNAT, Pof1, pyridine nucleotide adenylyltransferase, Tc00.1047053507047.170, TK0067, TTHA1780, yNMNAT-1, yNMNAT-2

ECTree

2 Transferases

2.7 Transferring phosphorus-containing groups

2.7.7 Nucleotidyltransferases

2.7.7.1 nicotinamide-nucleotide adenylyltransferase

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Results	in table
9	Activating Compound
8551	AA Sequence
10	Application
1	CAS Registry Number
39	Cloned(Commentary)
21	Crystallization (Commentary)
404	Disease/ Diagnostics
6	Expression
53	General Information
13	General Stability
11	IC50 Value
57	Inhibitors
27	kcat/KM [mM/s]
66	Ki Value [mM]
213	KM Value [mM]
51	Localization
86	Metals/Ions
60	Molecular Weight [Da]
87	Natural Substrates/ Products (Substrates)
368	Organism
6	Pathway
67	PDB ID
25	pH Optimum
2	pH Range
3	pH Stability
13	pI Value
12	Posttranslational Modification
42	Protein Variants
50	Purification (Commentary)
6	Reaction
11	Reaction Type
144	Reference
136	Source Tissue
31	Specific Activity [micromol/min/mg]
24	Storage Stability
297	Substrates and Products (Substrate)
61	Subunits
194	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]
4	Temperature Range [°C]
20	Temperature Stability [°C]
57	Turnover Number [1/s]

General Stability

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General Stability on EC 2.7.7.1 - nicotinamide-nucleotide adenylyltransferase

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bovine serum albumin stabilizes

Saccharomyces cerevisiae

642787, 642788

chaotropic anions are strong destabilizers of the enzyme

2 entries

concentration procedures including lyophilization, dialysis against solid sucrose, membrane ultrafiltration lead to marked loss of activity

Gallus gallus

642786

dithiothreitol and EDTA stabilize during purification

Homo sapiens

642779

dithiothreitol has no effect up to 50°C but destabilizes the enzyme at higher temperatures

Saccharolobus solfataricus

642808

dithiothreitol stabalizes enzyme NMNAT-2

Homo sapiens

642794

dithiothreitol stabilizes during purification

Sus scrofa

642784

extremely labile in crude extracts, even in the presence of PMSF and sodium metabisulfite, EDTA or DTT does not stabilize

Homo sapiens

642779

increasing ionic strenght of NaCl and KCl stabilizes the thermal stability of the enzyme

2 entries

very sensitive to freeze-thawing, 50% glycerol stabilizes

Homo sapiens

642779