2.7.7.13: mannose-1-phosphate guanylyltransferase
This is an abbreviated version!
For detailed information about mannose-1-phosphate guanylyltransferase, go to the full flat file.
Word Map on EC 2.7.7.13
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2.7.7.13
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asa
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phosphomannomutase
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l-ascorbic
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limb-girdle
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myasthenic
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l-galactose
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dystroglycanopathies
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gmpase
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gdp-l-galactose
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mannose-containing
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alpha-dystroglycan
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l-galactono-1,4-lactone
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smirnoff-wheeler
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acerola
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l-galactose-1-phosphate
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drug development
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synthesis
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medicine
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agriculture
- 2.7.7.13
- asa
- phosphomannomutase
-
l-ascorbic
-
limb-girdle
-
myasthenic
- l-galactose
- dystroglycanopathies
-
gmpase
- gdp-l-galactose
-
mannose-containing
- alpha-dystroglycan
- l-galactono-1,4-lactone
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smirnoff-wheeler
- acerola
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l-galactose-1-phosphate
- drug development
- synthesis
- medicine
- agriculture
Reaction
Synonyms
BceA, BceA(J) protein, BceAJ, CYT1, GDP-alpha-D-mannose pyrophosphorylase, GDP-D-mannose pyrophosphorylase, GDP-Man pyrophosphorylase, GDP-mannose pyrophosphorylase, GDP-mannose pyrophosphorylase B, GDP-ManPP, GDP-MP, GDPMan pyrophosphorylase, GMP, GMP3, GMPase, GMPBB, GMPP, GMPP1, GMPP2, GMPP3, GMPPB, GTP-alpha-D-Man-1-P guanylyltransferase, GTP-mannose 1-phosphate guanylyltransferase, GTP-mannose-1-phosphate guanylyltransferase, guanidine diphosphomannose pyrophosphorylase, guanidine diphosphomannose pyrophoyphorylase, guanosine 5'-diphosphate-mannose pyrophosphorylase, guanosine 5'-diphospho-D-mannose pyrophosphorylase, guanosine diphosphate mannose pyrophosphorylase, guanosine diphosphate mannose pyrophosphorylase B, guanosine diphosphate-mannose pyrophosphorylase, guanosine diphosphomannose pyrophosphorylase, guanosine triphosphate-mannose 1-phosphate guanylyltransferase, guanosine-diphospho-D-mannose pyrophosphorylase, guanylyltransferase, mannose 1-phosphate, LDBPK_230120, Man-1-PGTase, mannose 1-phosphate guanyltransferase, mannose 1-phosphate guanylyltransferase (guanosine triphosphate), mannose-1-phosphate guanyl transferase, mannose-1-phosphate guanyltransferase beta, mannose-1-phosphate guanylyltransferase, More, MPG, MPG transferase, multiple sugar-1-P NTase, NDP-sugar pyrophosphorylase, NSPase, Os01g0847200, Os03g0268400, OsVTC1-1, OsVTC1-3, OsVTC1-8, PFManC, PH0925, PH0925 protein, PIM-GMP, RfbM, VCT1-1, VCT1-3, VTC1, VTC1-1, VTC1-3
ECTree
2.7.7.13 mannose-1-phosphate guanylyltransferaseAdvanced search results
results (
results (Engineering
Engineering on EC 2.7.7.13 - mannose-1-phosphate guanylyltransferase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
D27H/V330I
mutation identified in patient with muscular dystrophy
P22S/D334N
mutation identified in patient with muscular dystrophy
R74*/D334N
mutation identified in patient with muscular dystrophy
K175E
approx. 9% of wild-type activity, 600fold increase in Km for mannose 1-phosphate
K175Q
approx. 40% of wild-type activity, 3200fold increase in Km for mannose 1-phosphate
K20Q
enzyme is unable to support alginate synthesis although it shows no significant differences in Vmax and Km as compared to wild-type
R19H
approx. 50% of wild-type activity, 8fold increase in Km for mannose 1-phosphate
R19K
approx. 50% of wild-type activity, 2 and 6fold increase in Km for mannose 1-phosphate and GTP, respectively
R19L
approx. 50% of wild-type activity, 5fold increase in Km for mannose 1-phosphate and GTP, respectively
S12A
approx. 44% of wild-type activity, 2 and 3fold decrease in Km for mannose 1-phosphate and GTP, respectively
additional information
additional information
construction of the conditional inactivation mutant strain YJ-gmpp by replacement of the native Afsrb1 promoter with an inducible Aspergillus nidulans alcA promoter. Repression of GMPP in yeast leads to phenotypes including hyphal lysis, defective cell wall, and failure of polarized growth and branching site selection, and cell separation, inactivation phenotype, overview. The alkali-soluble alpha-glucan and alkali-insoluble beta-glucan contents remain unchanged in strain YJ-gmpp depleted of Afsrb1, while the alkali-soluble protein and alkali-insoluble chitin contents are 1.3 and 2.0fold higher, respectively, than those of the wild-type
additional information
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construction of the conditional inactivation mutant strain YJ-gmpp by replacement of the native Afsrb1 promoter with an inducible Aspergillus nidulans alcA promoter. Repression of GMPP in yeast leads to phenotypes including hyphal lysis, defective cell wall, and failure of polarized growth and branching site selection, and cell separation, inactivation phenotype, overview. The alkali-soluble alpha-glucan and alkali-insoluble beta-glucan contents remain unchanged in strain YJ-gmpp depleted of Afsrb1, while the alkali-soluble protein and alkali-insoluble chitin contents are 1.3 and 2.0fold higher, respectively, than those of the wild-type
additional information
-
construction of the conditional inactivation mutant strain YJ-gmpp by replacement of the native Afsrb1 promoter with an inducible Aspergillus nidulans alcA promoter. Repression of GMPP in yeast leads to phenotypes including hyphal lysis, defective cell wall, and failure of polarized growth and branching site selection, and cell separation, inactivation phenotype, overview. The alkali-soluble alpha-glucan and alkali-insoluble beta-glucan contents remain unchanged in strain YJ-gmpp depleted of Afsrb1, while the alkali-soluble protein and alkali-insoluble chitin contents are 1.3 and 2.0fold higher, respectively, than those of the wild-type
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additional information
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OsMPG1 is localized in the cytoplasm and its overexpression confers salinity stress tolerance in transgenic tobacco
additional information
generation of OsVTC1-1 silenced mutant plants by RNAi method
additional information
generation of OsVTC1-1 silenced mutant plants by RNAi method
additional information
generation of OsVTC1-1 silenced mutant plants by RNAi method
additional information
generation of OsVTC1-3 silenced mutant plants by RNAi method
additional information
generation of OsVTC1-3 silenced mutant plants by RNAi method
additional information
generation of OsVTC1-3 silenced mutant plants by RNAi method
additional information
generation of OsVTC1-8 silenced mutant plants by RNAi method
additional information
generation of OsVTC1-8 silenced mutant plants by RNAi method
additional information
generation of OsVTC1-8 silenced mutant plants by RNAi method
additional information
construction of several truncated mutants of the PH0925 protein, that show altered kinetics compared to the wild-type enzyme, overview
additional information
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construction of several truncated mutants of the PH0925 protein, that show altered kinetics compared to the wild-type enzyme, overview
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additional information
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construction of several truncated mutants of the PH0925 protein, that show altered kinetics compared to the wild-type enzyme, overview
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additional information
generation of GMP3 overexpressing and RNAi knockdown lines
additional information
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generation of GMP3 overexpressing and RNAi knockdown lines
